Results 1 to 10 of about 89,658 (280)

IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. [PDF]

PLoS Genetics, 2023
Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into the ...
Zeineb Bakey, Oscar A Cabrera, Julia Hoefele, Dinu Antony, Kaman Wu, Michael W Stuck, Dimitra Micha, Thibaut Eguether, Abigail O Smith, Nicole N van der Wel, Matias Wagner, Lara Strittmatter, Philip L Beales, Julie A Jonassen, Isabelle Thiffault, Maxime Cadieux-Dion, Laura Boyes, Saba Sharif, Beyhan Tüysüz, Desiree Dunstheimer, Hans W M Niessen, William Devine, Cecilia W Lo, Hannah M Mitchison, Miriam Schmidts, Gregory J Pazour   +25 more
doaj   +6 more sources

Assessing motile cilia coverage and beat frequency in mammalian in vitro cell culture tissues [PDF]

Royal Society Open Science, 2023
Cilia density, distribution and beating frequency are important properties of airway epithelial tissues. These parameters are critical in diagnosing primary ciliary dyskinesia and examining in vitro models, including those derived from induced ...
Ricardo Fradique, Erika Causa, Clara Delahousse, Jurij Kotar, Laetitia Pinte, Ludovic Vallier, Marta Vila-Gonzalez, Pietro Cicuta   +7 more
doaj   +4 more sources

Microridge-like structures anchor motile cilia [PDF]

Nature Communications, 2022
Several tissues contain cells with multiple motile cilia that generate a fluid or particle flow to support development and organ functions; defective motility causes human disease.
Takayuki Yasunaga, Johannes Wiegel, Max D. Bergen, Martin Helmstädter, Daniel Epting, Andrea Paolini, Özgün Çiçek, Gerald Radziwill, Christina Engel, Thomas Brox, Olaf Ronneberger, Peter Walentek, Maximilian H. Ulbrich, Gerd Walz   +13 more
doaj   +6 more sources

Cilia density and flow velocity affect alignment of motile cilia from brain cells [PDF]

Journal of Experimental Biology, 2020
In many organs, thousands of microscopic ‘motile cilia’ beat in a coordinated fashion generating fluid flow. Physiologically, these flows are important in both development and homeostasis of ciliated tissues.
Nicola Pellicciotta, Pietro Cicuta, Jurij Kotar, Debasish Das, Eric Lauga, Marion Faucourt, Nathalie Spassky   +6 more
semanticscholar   +7 more sources

The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision [PDF]

Nature Communications, 2022
Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated domains
Paul W. Chrystal, Nils J. Lambacher, Lance P. Doucette, James Bellingham, Elena R. Schiff, Nicole C. L. Noel, Chunmei Li, Sofia Tsiropoulou, Geoffrey A. Casey, Yi Zhai, Nathan J. Nadolski, Mohammed H. Majumder, Julia Tagoe, Fabiana D’Esposito, Maria Francesca Cordeiro, Susan Downes, Jill Clayton-Smith, Jamie Ellingford, Genomics England Research Consortium, Omar A. Mahroo, Jennifer C. Hocking, Michael E. Cheetham, Andrew R. Webster, Gert Jansen, Oliver E. Blacque, W. Ted Allison, Ping Yee Billie Au, Ian M. MacDonald, Gavin Arno, Michel R. Leroux   +29 more
doaj   +3 more sources

The regulatory roles of motile cilia in CSF circulation and hydrocephalus [PDF]

Fluids and Barriers of the CNS, 2021
Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine.
Vijay Kumar, Zobia Umair, Shiv Kumar, Ravi Shankar Goutam, Soochul Park, Jaebong Kim   +5 more
doaj   +3 more sources

Highly motile nanoscale magnetic artificial cilia [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance Cilia are hair-like microscopic structures present abundantly in our body and producing motions at the smallest scales. They perform a wide range of critical functions and are crucial for the normal functioning of our body. Abnormal functioning of cilia results in a number of diseases jointly known as ciliopathies.
Tanveer ul Islam, Yves Bellouard, Jaap M. J. den Toonder   +2 more
openalex   +4 more sources

Motile Cilia: Innovation and Insight From Ciliate Model Organisms [PDF]

Frontiers in Cell and Developmental Biology, 2019
Ciliates are a powerful model organism for the study of basal bodies and motile cilia. These single-celled protists contain hundreds of cilia organized in an array making them an ideal system for both light and electron microscopy studies.
Brian A. Bayless, Francesca M. Navarro, Mark Winey   +2 more
doaj   +6 more sources

Motile cilia and airway disease. [PDF]

Seminars in Cell & Developmental Biology, 2020
A finely regulated system of airway epithelial development governs the differentiation of motile ciliated cells of the human respiratory tract, conferring the body's mucociliary clearance defence system. Human cilia dysfunction can arise through genetic mutations and this is a cause of debilitating disease morbidities that confer a greatly reduced ...
M. Legendre, L. Zaragosi, H. Mitchison
semanticscholar   +5 more sources

SnapShot: Motile Cilia

Cell, 2015
Motile cilia are hair-like organelles that protrude from the cell surface and are conserved throughout eukaryotes. Motile cilia beat rhythmically and function in cellular and organismal locomotion and in driving fluid transport over epithelia. In vertebrates, their roles are varied, and their dysfunction in humans is associated with disease.
Feng Zhou, Sudipto Roy
openalex   +3 more sources