Results 1 to 10 of about 87,864 (261)

Microridge-like structures anchor motile cilia. [PDF]

Nat Commun, 2022
AbstractSeveral tissues contain cells with multiple motile cilia that generate a fluid or particle flow to support development and organ functions; defective motility causes human disease. Developmental cues orient motile cilia, but how cilia are locked into their final position to maintain a directional flow is not understood.
Yasunaga T, Wiegel J, Bergen MD, Helmstädter M, Epting D, Paolini A, Çiçek Ö, Radziwill G, Engel C, Brox T, Ronneberger O, Walentek P, Ulbrich MH, Walz G.   +13 more
europepmc   +8 more sources

The regulatory roles of motile cilia in CSF circulation and hydrocephalus. [PDF]

Fluids Barriers CNS, 2021
This article was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology of Korea (2016R1D1A1B02008770, 2016M3A9B8914057 ...
Kumar V, Umair Z, Kumar S, Goutam RS, Park S, Kim J.   +5 more
europepmc   +11 more sources

The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision. [PDF]

Nat Commun, 2022
Motile and non-motile cilia are associated with mutually-exclusive genetic disorders. Motile cilia propel sperm or extracellular fluids, and their dysfunction causes primary ciliary dyskinesia.
Chrystal PW, Lambacher NJ, Doucette LP, Bellingham J, Schiff ER, Noel NCL, Li C, Tsiropoulou S, Casey GA, Zhai Y, Nadolski NJ, Majumder MH, Tagoe J, D'Esposito F, Cordeiro MF, Downes S, Clayton-Smith J, Ellingford J, Genomics England Research Consortium, Mahroo OA, Hocking JC, Cheetham ME, Webster AR, Jansen G, Blacque OE, Allison WT, Au PYB, MacDonald IM, Arno G, Leroux MR.   +29 more
europepmc   +9 more sources

IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. [PDF]

PLoS Genet, 2023
Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into the ...
Bakey Z, Cabrera OA, Hoefele J, Antony D, Wu K, Stuck MW, Micha D, Eguether T, Smith AO, van der Wel NN, Wagner M, Strittmatter L, Beales PL, Jonassen JA, Thiffault I, Cadieux-Dion M, Boyes L, Sharif S, Tüysüz B, Dunstheimer D, Niessen HWM, Devine W, Lo CW, Mitchison HM, Schmidts M, Pazour GJ.   +25 more
europepmc   +8 more sources

The methylome of motile cilia. [PDF]

Mol Biol Cell
Cilia are highly complex motile, sensory, and secretory organelles that contain perhaps 1000 or more distinct protein components, many of which are subject to various posttranslational modifications such as phosphorylation, N-terminal acetylation, and proteolytic processing.
King SM, Sakato-Antoku M, Patel-King RS, Balsbaugh JL.   +3 more
europepmc   +6 more sources

Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia. [PDF]

Int J Mol Sci, 2021
Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many ciliated organs that include primary cilia as well as motile cilia. Using zebrafish as an animal model helps
Pinto AL, Rasteiro M, Bota C, Pestana S, Sampaio P, Hogg C, Burgoyne T, Lopes SS.   +7 more
europepmc   +7 more sources

The transcriptional signature associated with human motile cilia. [PDF]

Sci Rep, 2020
AbstractCilia are complex microtubule-based organelles implicated in the aetiology of numerous diseases. Accordingly, many cilia-associated proteins have been described, while those distinguishing cilia subtypes are poorly defined. Here, we characterise the gene signature associated with human motile cilia that captures both known and unknown ...
Patir A, Fraser AM, Barnett MW, McTeir L, Rainger J, Davey MG, Freeman TC.   +6 more
europepmc   +10 more sources

Neuronal coordination of motile cilia in locomotion and feeding. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2020
Efficient ciliary locomotion and transport require the coordination of motile cilia. Short-range coordination of ciliary beats can occur by biophysical mechanisms. Long-range coordination across large or disjointed ciliated fields often requires nervous system control and innervation of ciliated cells by ciliomotor neurons.
Marinković M, Berger J, Jékely G.
europepmc   +7 more sources

Realizing the physics of motile cilia synchronization with driven colloids [PDF]

Annual Review of Condensed Matter Physics, 2015
Cilia and flagella in biological systems often show large scale cooperative behaviors such as the synchronization of their beats in "metachronal waves".
Bruot, Nicolas, Cicuta, Pietro
core   +6 more sources

SnapShot: Motile Cilia [PDF]

Cell, 2015
Motile cilia are hair-like organelles that protrude from the cell surface and are conserved throughout eukaryotes. Motile cilia beat rhythmically and function in cellular and organismal locomotion and in driving fluid transport over epithelia.
Roy, Sudipto, Zhou, Feng
core   +4 more sources