ARL13B controls male reproductive tract physiology through primary and Motile Cilia [PDF]
Communications BiologyARL13B is a small regulatory GTPase that controls ciliary membrane composition in both motile cilia and non-motile primary cilia. In this study, we investigated the role of ARL13B in the efferent ductules, tubules of the male reproductive tract essential
Céline Augière +13 more
doaj +3 more sources
The methylome of motile cilia [PDF]
Molecular Biology of the CellCilia are highly complex motile, sensory, and secretory organelles that contain perhaps 1000 or more distinct protein components, many of which are subject to various posttranslational modifications such as phosphorylation, N-terminal acetylation, and ...
Stephen M. King +3 more
semanticscholar +4 more sources
Motile Cilia in Female and Male Reproductive Tracts and Fertility [PDF]
CellsMotile cilia are evolutionarily conserved organelles. In humans, multiciliated cells (MCCs), assembling several hundred motile cilia on their apical surface, are components of the monolayer epithelia lining lower and upper airways, brain ventricles, and ...
Dorota Wloga +4 more
doaj +3 more sources
SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance [PDF]
bioRxiv, 2020 Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. We examined the functional and structural consequences of SARS-CoV-2 infection in a reconstituted human ...
Rémy Robinot +24 more
semanticscholar +3 more sources
Structural diversity of axonemes across mammalian motile cilia [PDF]
NatureReproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii1,
M. Leung +9 more
semanticscholar +4 more sources
The transcriptional signature associated with human motile cilia [PDF]
Scientific Reports, 2019 Cilia are complex microtubule-based organelles essential to a range of processes associated with embryogenesis and tissue homeostasis. Mutations in components of these organelles or those involved in their assembly may result in a diverse set of diseases
Anirudh Patir +6 more
semanticscholar +5 more sources
Pathogenic KIAA0586/TALPID3 variants are associated with defects in primary and motile cilia [PDF]
iScienceSummary: Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway ...
Jacqueline E. Taudien +22 more
doaj +3 more sources
SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming [PDF]
Cell, 2022 Chien-Ting Wu +21 more
semanticscholar +4 more sources
Epilepsy protein Efhc1/myoclonin1 is expressed in cells with motile cilia but not in neurons or mitotic apparatuses in brain [PDF]
Sci Rep, 2020 EFHC1 gene encodes the myoclonin1 protein, also known as Rib72-1. Pathogenic variants in EFHC1 have been reported in patients with juvenile myoclonic epilepsy (JME).
Toshimitsu Suzuki +2 more
semanticscholar +3 more sources
LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus [PDF]
Cell Commun Signal, 2023 Background LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm.
Dong Yun Kim +8 more
semanticscholar +2 more sources