Results 11 to 20 of about 87,864 (261)

Motile and non‐motile cilia in human pathology: from function to phenotypes [PDF]

The Journal of Pathology, 2016
AbstractCiliopathies are inherited human disorders caused by both motile and non‐motile cilia dysfunction that form an important and rapidly expanding disease category. Ciliopathies are complex conditions to diagnose, being multisystem disorders characterized by extensive genetic heterogeneity and clinical variability with high levels of lethality ...
Mitchison, Hannah M., VALENTE, ENZA MARIA   +1 more
semanticscholar   +7 more sources

Entrainment of mammalian motile cilia in the brain with hydrodynamic forces. [PDF]

Proc Natl Acad Sci U S A, 2020
Motile cilia are widespread across the animal and plant kingdoms, displaying complex collective dynamics central to their physiology. Their coordination mechanism is not generally understood, with previous work mainly focusing on algae and protists.
Pellicciotta N, Hamilton E, Kotar J, Faucourt M, Delgehyr N, Spassky N, Cicuta P.   +6 more
europepmc   +7 more sources

Assessing motile cilia coverage and beat frequency in mammalian in vitro cell culture tissues. [PDF]

R Soc Open Sci, 2023
Cilia density, distribution and beating frequency are important properties of airway epithelial tissues. These parameters are critical in diagnosing primary ciliary dyskinesia and examining in vitro models, including those derived from induced ...
Fradique R, Causa E, Delahousse C, Kotar J, Pinte L, Vallier L, Vila-Gonzalez M, Cicuta P.   +7 more
europepmc   +3 more sources

Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. [PDF]

Mol Biol Cell, 2022
Hydrodynamic flow produced by multi-ciliated cells is critical for fluid circulation and cell motility. Hundreds of cilia beat with metachronal synchrony for fluid flow.
Soh AWJ, Woodhams LG, Junker AD, Enloe CM, Noren BE, Harned A, Westlake CJ, Narayan K, Oakey JS, Bayly PV, Pearson CG.   +10 more
europepmc   +4 more sources

Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis. [PDF]

Front Cell Dev Biol, 2022
It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 + 2 pattern) in kidney biopsies of 11 ...
Eymael J, Willemsen B, Xu J, Mooren F, Steenbergen E, Wetzels JF, Dijkman H, Jansen J, Van der Vlag J, Smeets B.   +9 more
europepmc   +4 more sources

Motile cilia and airway disease [PDF]

Seminars in Cell & Developmental Biology, 2021
A finely regulated system of airway epithelial development governs the differentiation of motile ciliated cells of the human respiratory tract, conferring the body's mucociliary clearance defence system. Human cilia dysfunction can arise through genetic mutations and this is a cause of debilitating disease morbidities that confer a greatly reduced ...
Laure-Emmanuelle Zaragosi, Marie Legendre, Hannah M. Mitchison, Hannah M. Mitchison   +3 more
openaire   +5 more sources

Impact of motile ciliopathies on human development and clinical consequences in the newborn [PDF]

Cells, 2021
Motile cilia are hairlike organelles that project outward from a tissue-restricted subset of cells to direct fluid flow. During human development motile cilia guide determination of the left-right axis in the embryo, and in the fetal and neonatal periods
Brody, Steven L, Hyland, Rachael
core   +4 more sources

SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. [PDF]

Cell, 2023
Wu CT, Lidsky PV, Xiao Y, Cheng R, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R, Jackson PK.   +21 more
europepmc   +4 more sources

Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia. [PDF]

Commun Biol
Motile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized ciliary motility. The formation of motile cilia is dependent on precisely controlled sequential processes including the generation,
Lee M, Carpenter C, Hwang YS, Yoon J, Lu Q, Westlake CJ, Moody SA, Yamaguchi TP, Daar IO.   +8 more
europepmc   +3 more sources

Structural diversity of axonemes across mammalian motile cilia. [PDF]

Nature
Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii1,
Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R.   +9 more
europepmc   +3 more sources