Results 21 to 30 of about 89,658 (280)
Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord [PDF]
Nature Communications, 2020 Ependymal cells (ECs) are multiciliated neuroepithelial cells that line the ventricles of the brain and the central canal of the spinal cord (SC). How ependymal motile cilia are maintained remains largely unexplored.
Jun Zhang +20 more
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Cyclic GMP and Cilia Motility [PDF]
Cells, 2015 Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense.
Todd A. Wyatt
doaj +3 more sources
Axoneme Structure from Motile Cilia. [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 The axoneme is the main extracellular part of cilia and flagella in eukaryotes. It consists of a microtubule cytoskeleton, which normally comprises nine doublets. In motile cilia, dynein ATPase motor proteins generate sliding motions between adjacent microtubules, which are integrated into a well-orchestrated beating or rotational motion.
T. Ishikawa
semanticscholar +3 more sources
eLife, 2017 Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia ...
Barbara Tavares +12 more
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Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport [PDF]
Proc Natl Acad Sci U S A, 2021 Significance The oviduct is essential for female fertility due to its two main functions: transport and nourishment. While the nourishment role is mainly fulfilled by secretory cells, the relative contribution to the transport function by ciliated cells ...
Shuiqiao Yuan +6 more
semanticscholar +2 more sources
bioRxiv, 2023 Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies motile ciliopathies, a broad class of human diseases.
Caitlin McCafferty +6 more
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Motile and non‐motile cilia in human pathology: from function to phenotypes [PDF]
The Journal of Pathology, 2017 AbstractCiliopathies are inherited human disorders caused by both motile and non‐motile cilia dysfunction that form an important and rapidly expanding disease category. Ciliopathies are complex conditions to diagnose, being multisystem disorders characterized by extensive genetic heterogeneity and clinical variability with high levels of lethality ...
H. Mitchison, E. Valente
semanticscholar +8 more sources
Intracellular connections between basal bodies promote the coordinated behavior of motile cilia [PDF]
Mol Biol Cell, 2022 Hydrodynamic flow produced by multi-ciliated cells is critical for fluid circulation and cell motility. Hundreds of cilia beat with metachronal synchrony for fluid flow.
Adam W. J. Soh +10 more
semanticscholar +2 more sources
Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis [PDF]
Front Cell Dev Biol, 2022 It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 + 2 pattern) in kidney biopsies of 11 ...
Jennifer Eymael +9 more
semanticscholar +2 more sources
Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia.
PLoS Genetics, 2020 Motile cilia/flagella are essential for swimming and generating extracellular fluid flow in eukaryotes. Motile cilia harbor a 9+2 arrangement consisting of nine doublet microtubules with dynein arms at the periphery and a pair of singlet microtubules at ...
Hiroshi Yoke +7 more
doaj +2 more sources