Results 91 to 100 of about 722,567 (342)

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]

, 2015
BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott, Mante, Michael, Masliah, Eliezer, Rockenstein, Edward, Valera, Elvira   +4 more
core   +2 more sources

Motor proteins: Myosin V –  the multi-purpose transport motor [PDF]

Current Biology, 1997
Studies in yeast and mice suggest that myosin V participates in the directed transport of a number of distinct cargos to polarized regions of the cell; myosin V has also been implicated in the provision of materials for filopodial extension in neurons.
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Understanding Mechanochemical Coupling in Kinesins Using First-Passage Time Processes

, 2004
Kinesins are processive motor proteins that move along microtubules in a stepwise manner, and their motion is powered by the hydrolysis of ATP. Recent experiments have investigated the coupling between the individual steps of single kinesin molecules and
A. B. Kolomeisky, A. B. Kolomeisky, A. Yildiz, Alex A. Popov, Anatoly B. Kolomeisky, D. Bray, Evgeny B. Stukalin, H. Lodish, J. Howard, K. Svoboda, M. E. Fisher, N. G. van Kampen   +11 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Protein multi-scale organization through graph partitioning and robustness analysis: Application to the myosin-myosin light chain interaction

, 2011
Despite the recognized importance of the multi-scale spatio-temporal organization of proteins, most computational tools can only access a limited spectrum of time and spatial scales, thereby ignoring the effects on protein behavior of the intricate ...
A Delmotte, Aynaud T, Blondel V D, Delano W L, Delmotte A, E W Tate, Hettmann C, Lambiotte R Delvenne J C Barahona M, M Barahona, Meliga S, Meliga S Yaliraki S N Barahona M, Newman M E J, S N Yaliraki, Schiaffino S   +13 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Frontiers in Aging Neuroscience, 2017
Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose ...
Luxi Wang, Nian Xiong, Jinsha Huang, Shiyi Guo, Ling Liu, Chao Han, Guoxin Zhang, Haiyang Jiang, Kai Ma, Yun Xia, Xiaoyun Xu, Jie Li, Jing Y. Liu, Tao Wang   +13 more
doaj   +1 more source

Energetics and efficiency of a molecular motor model

, 2013
The energetics and efficiency of a linear molecular motor model proposed by Mogilner et al. (Phys. Lett. 237, 297 (1998)) is analyzed from an analytical point of view.
Fogedby, Hans C., Svane, Axel
core   +1 more source