Results 101 to 110 of about 438,155 (307)

A cyclic GMP signalling module that regulates gliding motility in a malaria parasite [PDF]

, 2009
The ookinete is a motile stage in the malaria life cycle which forms in the mosquito blood meal from the zygote. Ookinetes use an acto-myosin motor to glide towards and penetrate the midgut wall to establish infection in the vector.
Taylor, C.J., Baker, David A, Goulding, David, Claudia Bex, David A Baker, Schepers Rebecca, Waters Andrew P., Schepers, Rebecca, Waters, A.P., Oliver Billker, Billker Oliver, Goulding, D., Billker, Oliver,, Bex, C., Taylor, Cathy J, Rebecca Schepers, Schepers, R., Moon, Robert W, Bex, Claudia, Janse, Chris J, David Goulding, Robert W Moon, Billker, Oliver, Billker, O., Janse, C.J., Waters, Andrew P, Baker David A., Cathy J Taylor, Moon Robert W., Janse Chris J., Chris J Janse, Bex Claudia, Taylor Cathy J., Moon, R.W., Goulding David, Baker, D.A., Andrew P Waters   +36 more
core   +1 more source

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Frontiers in Aging Neuroscience, 2017
Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose ...
Luxi Wang, Nian Xiong, Jinsha Huang, Shiyi Guo, Ling Liu, Chao Han, Guoxin Zhang, Haiyang Jiang, Kai Ma, Yun Xia, Xiaoyun Xu, Jie Li, Jing Y. Liu, Tao Wang   +13 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. [PDF]

, 2012
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs.
Stephanie Barth, Neuenkirchen, N., Alfredo Mamiani (146650), Grässer, Friedrich A., Ostareck-Lederer, Antje, Leonhardt, Heinrich, Nils Neuenkirchen (146673), Fischer, Utz, Bodo Moritz, Friedrich A Grässer, Wen Deng, Masouris, Ilias, Barth, Stephanie, Fischer, U., Hennard, C., Christian Cassel, Neuenkirchen, Nils, Utz Fischer (146680), Utz Fischer, Ute Stober-Grässer (146645), Elfriede Noessner (146689), Noessner, Elfriede, Henrik Gross (146622), Bodo Moritz (146655), Dirk Ostareck, Mamiani, Alfredo, Stephanie Barth (145387), Nößner, E., Alfredo Mamiani, Ostareck, Dirk, Christine Hennard (146627), Christian Cassel (146638), Moritz, Bodo, Antje Ostareck-Lederer, Elfriede Noessner, Deng, Wen, Gross, H., Christine Hennard, Ostareck, Dirk H., Antje Ostareck-Lederer (146668), Dirk Ostareck (146662), Heinrich Leonhardt (18589), Henrik Gross, Stober-Grässer, U., Masouris, I., Friedrich A. Grässer (145412), Kremmer, E., Wen Deng (123626), Grässer, F.A., Kremmer, Elisabeth, Cassel, C., Deng, W., Ilias Masouris (146632), Ilias Masouris, Ostareck-Lederer, A., Mamiani, A., Heinrich Leonhardt, Gross, Henrik, Moritz, B., Nils Neuenkirchen, Barth, S., Ostareck, D., Cassel, Christian, Stober-Grässer, Ute, Elisabeth Kremmer (17351), Ute Stober-Grässer, Elisabeth Kremmer, Leonhardt, H., Hennard, Christine   +68 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Studies on the interaction between "Tobacco Mosaic Virus" movement protein and microtubules [PDF]

, 2003
During the invasion of a susceptible host, Tobacco mosaic virus (TMV) transports its RNA genome from sites of viral synthesis into neighbouring cells, thus potentiating the spread of infection.
Ashby, Jamie A.
core   +1 more source

Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice

Neurobiology of Disease, 2012
The small heat shock protein HSPB1 is a multifunctional, α-crystallin-based protein that has been shown to be neuroprotective in animal models of motor neuron disease and peripheral nerve injury. Missense mutations in HSPB1 result in axonal Charcot–Marie–
Amit K. Srivastava, Samantha R. Renusch, Nicole E. Naiman, Shuping Gu, Amita Sneh, W. David Arnold, Zarife Sahenk, Stephen J. Kolb   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source