Results 71 to 80 of about 438,155 (307)

Unfolded protein responses in models of Motor Neuron Disease

, 2010
Motor neuron disorders are a heterogeneous group of diseases characterized by the selective degeneration of motor neurons leading to muscle wasting and atrophy.
Kwok, Alice
core   +1 more source

A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae [PDF]

, 2001
In vivo time-lapse microscopy reveals that the number of peroxisomes in Saccharomyces cerevisiae cells is fairly constant and that a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process.
Marlene van den Berg, Hettema, E.H., Peter Philippsen, Henk F. Tabak, Hoepfner, D., Tabak, H.F., Dominic Hoepfner, Tabak, H. F., Hettema, E. H., Ewald H. Hettema, van den Berg, M., Philippsen, P.   +11 more
core   +1 more source

On helicases and other motor proteins [PDF]

Current Opinion in Structural Biology, 2008
Helicases are molecular machines that utilize energy derived from ATP hydrolysis to move along nucleic acids and to separate base-paired nucleotides. The movement of the helicase can also be described as a stationary helicase that pumps nucleic acid. Recent structural data for the hexameric E1 helicase of papillomavirus in complex with single-stranded ...
Eric J, Enemark, Leemor, Joshua-Tor
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Cross-modal sensory signaling shapes vestibulo-motor circuit specificity [PDF]

, 2015
The ability to continuously adjust posture and balance is necessary for reliable motor behavior. Vestibular and proprioceptive systems influence postural adjustments during movement by signaling functionally complementary sensory information. Using
Basaldella, Emanuela
core   +1 more source

Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons

Acta Neuropathologica Communications, 2020
Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of lower motor neurons, which leads to proximal muscle weakness and atrophy.
Maximilian Paul Thelen, Brunhilde Wirth, Min Jeong Kye   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity

, 2010
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L., Federica Catti, David M Warshaw, Nicholas J Westwood, Catti, Federica, Gary E Ward, Jacqueline M Leung, Kimberly L Carey, Leung, Jacqueline M., Warshaw, David M., Ballif, Bryan A., Heaslip, Aoife T., Bryan A Ballif, Westwood, Nicholas J., Ward, Gary E., Aoife T Heaslip   +15 more
core   +1 more source

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]

, 2011
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub, Cramer, P., Andreas Mayer, Kramer, Katharina, Niessing, Dierk, Jansen, R., Urlaub, Henning, Heym Roland Gerhard, Heym, R. G., Schmid, M., Mueller, M., Heym, R.G., Müller, Marisa, Schmid Maria, Jansen Ralf-Peter, Cramer Patrick, Niessing, D., Roland Gerhard Heym, Kramer, K., Meyer, A., Urlaub Henning, Mayer, A., Müller Marisa, Jansen, Ralf-Peter, Jansen, R.P., Mayer Andreas, Maria Schmid, Cramer, Patrick, Schmid, Maria, Patrick Cramer, Urlaub, H., Katharina Kramer, Jansen, R.-P., Niessing Dierk, Ralf-Peter Jansen, Kramer Katharina, Müller, M., Heym, R., Mayer, Andreas, Dierk Niessing, Heym, Roland Gerhard, Marisa Müller   +41 more
core   +1 more source

Unraveling the fastest myosin: Discovery history and structure-function relationships of algae Chara myosin XI

Biophysics and Physicobiology
Plant myosins have higher velocities than animal myosins. Among them, myosins in freshwater algae of the genus Chara have extremely high velocities. We have biochemically studied myosins that perform high-speed movements in the alga Chara.
Kohji Ito, Takeshi Haraguchi
doaj   +1 more source