Results 61 to 70 of about 717,772 (297)

Structures of kinesin motor proteins [PDF]

Cell Motility, 2009
AbstractAlmost 25 years of kinesin research have led to the accumulation of a large body of knowledge about this widespread superfamily of motor and nonmotor proteins present in all eukaryotic cells. This review covers developments in kinesin research with an emphasis on structural aspects obtained by X‐ray crystallography and cryoelectron microscopy 3‐
Marx, A., Hoenger, A., Mandelkow, E.
openaire   +3 more sources

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice. [PDF]

PLoS ONE, 2010
Motor neuron degeneration in SOD1(G93A) transgenic mice begins at the nerve terminal. Here we examine whether this degeneration depends on expression of mutant SOD1 in muscle fibers.Hindlimb muscles were transplanted between wild-type and SOD1(G93A ...
Dario I Carrasco, Edyta K Bichler, Kevin L Seburn, Martin J Pinter   +3 more
doaj   +1 more source

A Python based automated tracking routine for myosin II filaments [PDF]

, 2020
The study of motor protein dynamics within cytoskeletal networks is of high interest to physicists and biologists to understand how the dynamics and properties of individual motors lead to cooperative effects and control of overall network behaviour ...
Köster, Darius Vasco, Mosby, Lewis S., Polin, Marco   +2 more
core   +2 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

A Master equation approach to modeling an artificial protein motor

, 2010
Linear bio-molecular motors move unidirectionally along a track by coordinating several different processes, such as fuel (ATP) capture, hydrolysis, conformational changes, binding and unbinding from a track, and center-of-mass diffusion.
Alberts, Allen, Astumian, Astumian, Astumian, Astumian, Balzani, Bath, Borden, Bromley, Bustamante, Carey, Craig, Eaton, Feringa, Finucane, Geertsema, Gerhard A. Blab, Greenleaf, Heiner Linke, Howard, Kay, Klok, Kottas, Magnasco, Nathan J. Kuwada, Parsons, Phillips, Schaad, Silvi, Stockley, van Delden, Vilfan, Vilfan, Wang, Yurke   +35 more
core   +1 more source

Adaptation to G93A superoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis. The role of glutathione [PDF]

, 2009
Motor neuron degeneration in amyotrophic lateral sclerosis involves oxidative damage. Glutathione (GSH) is critical as an antioxidant and a redox modulator.
AND LAVINIA CANTONI, D'ALESSANDRO, GIUSEPPINA, ELISABETTA BABETTO, LAURA CONFORTI, MILENA RIZZARDINI, SILVIA TARTARI   +5 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease

Neurobiology of Disease, 2022
Synaptojanin 2 binding protein (SYNJ2BP) is an outer mitochondrial membrane protein with a cytosolic PDZ domain that functions as a cellular signaling hub. Few studies have evaluated its role in disease.
Naemeh Pourshafie, Ester Masati, Amber Lopez, Eric Bunker, Allison Snyder, Nancy A. Edwards, Audrey M. Winkelsas, Kenneth H. Fischbeck, Christopher Grunseich   +8 more
doaj   +1 more source