Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Frontiers in Cell and Developmental Biology, 2022 Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott +4 more
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A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]
Royal Society Open Science, 2018 Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
L. Trott +2 more
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eLife, 2020 Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament.
Tatyana Bodrug +17 more
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KLC4 shapes axon arbors during development and mediates adult behavior
eLife, 2022 Development of elaborate and polarized neuronal morphology requires precisely regulated transport of cellular cargos by motor proteins such as kinesin-1. Kinesin-1 has numerous cellular cargos which must be delivered to unique neuronal compartments.
Elizabeth M Haynes +7 more
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Analysis of membrane structure of the inner ear motor protein prestin by force spectroscopy
Journal of Biomechanical Science and Engineering, 2021 The high sensitivity of mammalian hearing is achieved by cochlear amplification. The basis of this amplification is the motility of outer hair cells (OHCs), which are sensory cells in the inner ear.
Michio MURAKOSHI, Hiroshi WADA
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Myosin V executes steps of variable length via structurally constrained diffusion
eLife, 2020 The molecular motor myosin V transports cargo by stepping on actin filaments, executing a random diffusive search for actin binding sites at each step.
David Hathcock +3 more
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Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]
, 2016 Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J. +9 more
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Coupling of Two Motor Proteins: a New Motor Can Move Faster [PDF]
, 2005 We study the effect of a coupling between two motor domains in highly-processive motor protein complexes. A simple stochastic discrete model, in which the two parts of the protein molecule interact through some energy potential, is presented.
Anatoly B. Kolomeisky +8 more
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Length control of microtubules by depolymerizing motor proteins [PDF]
, 2008 In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the ...
B. S. Govindan +3 more
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Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]
, 2017 Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
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