Results 21 to 30 of about 701,388 (349)
Molecules, 2019 Kinesin-1, kinesin-2 and kinesin-5 are three families of a superfamily of motor proteins; which can walk processively on microtubule filaments by hydrolyzing ATP. It was experimentally shown that while the three kinesin dimers show similar feature on the
Si-Kao Guo +3 more
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Two- and Three-Dimensional Tracking of MFA2 mRNA Molecules in Mating Yeast
Cells, 2020 Intracellular mRNA transport contributes to the spatio-temporal regulation of mRNA function and localized translation. In the budding yeast, Saccharomyces cerevisiae, asymmetric mRNA transport localizes ~30 specific mRNAs including those encoding ...
Polina Geva +2 more
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Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]
, 2017 Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
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Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein
Frontiers in Neuroscience, 2021 Golgi defects including Golgi fragmentation are pathological features of Alzheimer’s disease (AD). As a pathogenic factor in AD, amyloid precursor protein (APP) induces Golgi fragmentation in the soma.
Qianqian Du +9 more
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The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance [PDF]
, 2011 The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares ...
Broihier, Heather T +3 more
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Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
Molecular Oncology, 2023 Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa +14 more
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Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies
eLife, 2022 The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan +6 more
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Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
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eLife, 2018 Motor and non-motor crosslinking proteins play critical roles in determining the size and stability of microtubule-based architectures. Currently, we have a limited understanding of how geometrical properties of microtubule arrays, in turn, regulate the ...
Sithara Wijeratne, Radhika Subramanian
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Autoinhibited kinesin-1 adopts a hierarchical folding pattern
eLife, 2023 Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan +7 more
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