Results 41 to 50 of about 722,567 (342)
New Journal of Physics, 2017 The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from the properties of the network’s constituent motor proteins and ...
Peter J Foster +4 more
doaj +1 more source
Kinesin motility is driven by subdomain dynamics
eLife, 2017 The microtubule (MT)-associated motor protein kinesin utilizes its conserved ATPase head to achieve diverse motility characteristics. Despite considerable knowledge about how its ATPase activity and MT binding are coupled to the motility cycle, the ...
Wonmuk Hwang +2 more
doaj +1 more source
eLife, 2014 The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear.
Alessandro Costa +9 more
doaj +1 more source
Limited phenotypic effects of selectively augmenting the SMN protein in the neurons of a mouse model of severe spinal muscular atrophy. [PDF]
PLoS ONE, 2012 The selective vulnerability of motor neurons to paucity of Survival Motor Neuron (SMN) protein is a defining feature of human spinal muscular atrophy (SMA) and indicative of a unique requirement for adequate levels of the protein in these cells. However,
Andrew J-H Lee +3 more
doaj +1 more source
Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice
Neurobiology of Disease, 2021 Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by survival motor neuron (SMN) protein deficiency which results in motor neuron loss and muscle atrophy. SMA is caused by a mutation or deletion of the survival motor neuron 1 (
Kaitlyn M. Kray +4 more
doaj +1 more source
Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]
, 2018 Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong +4 more
core +2 more sources
Motor proteins traffic regulation by supply-demand balance of resources
, 2014 In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow ...
Ciandrini, Luca +4 more
core +3 more sources
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice [PDF]
, 2016 Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43).
Alfieri, Julio Armando +2 more
core +2 more sources
eLife, 2014 X-ray crystallography has revealed an unusual structural element in kinesin-5 motor proteins.
Nikta Fakhri, Christoph F Schmidt
doaj +1 more source
Motion of rotatory molecular motor and chemical reaction rate
, 2003 We examine the dependence of the physical quantities of the rotatory molecular motor, such as the rotation velocity and the proton translocation rate, on the chemical reaction rate using the model based only on diffusion process.
D. Stock +23 more
core +1 more source