Results 51 to 60 of about 722,567 (342)

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances
A Gill, A Panatier, C Watson, C Zheng, Dominic J. Wells, DS Newman, EL Tudor, ET Cirulli, FJ Martinez, G Tedeschi, GM Alexander, HJ Chen, HM Kaneb, HMJ Kaneb, I Jotova, J Hegedus, J Mitchell, J Sasabe, J Sasabe, J Vincelette, Jacqueline P. Robbins, Jacqueline S. de Belleroche, JM Lincecum, JN Matthews, John C. W. Hildyard, JP Mothet, JP Taylor, Ke Liu, L-S Wu, LJ Wang, M Azzouz, M Azzouz, M Neumann, M Sasaki, ME Gurney, MJ Piesla, Nazanin Rahmani Kondori, P Paul, P Paul, Praveen Paul, PS Sharp, R Konno, R Konno, S McHanwell, S Scott, SL Almond, TG Hampton, Thomas H. Gillingwater, Y Li, Y Yang   +49 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Protein Synthesis Inhibition in the Peri-Infarct Cortex Slows Motor Recovery in Rats. [PDF]

PLoS ONE, 2016
Neuroplasticity and reorganization of brain motor networks are thought to enable recovery of motor function after ischemic stroke. Especially in the cortex surrounding the ischemic scar (i.e., peri-infarct cortex), evidence for lasting reorganization has
Maximilian Schubring-Giese, Susan Leemburg, Andreas Rüdiger Luft, Jonas Aurel Hosp   +3 more
doaj   +1 more source

Exact solution of a linear molecular motor model driven by two-step fluctuations and subject to protein friction

, 2003
We investigate by analytical means the stochastic equations of motion of a linear molecular motor model based on the concept of protein friction. Solving the coupled Langevin equations originally proposed by Mogilner et al. (A.
A. F. Huxley, A. K. Vidybida, Axel Svane, B. Alberts, D. P. Mulvihill, Hans C. Fogedby, J. Darnell, J. Howard, L. Stryer, M. von Smoluchowski, R. C. Woledge, R. H. Abeles, R. P. Feynman, Ralf Metzler   +13 more
core   +1 more source

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

eLife, 2014
Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod.
Jessica E Scholey, Stanley Nithianantham, Jonathan M Scholey, Jawdat Al-Bassam   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Assembly, remodelled

eLife, 2013
Biochemical assays reveal that nucleosome maturation and chromatin remodelling by the motor protein Chd1 are distinct, separable enzymatic activities.
Karim Bouazoune, Robert E Kingston
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source