Results 51 to 60 of about 701,388 (349)
Limited phenotypic effects of selectively augmenting the SMN protein in the neurons of a mouse model of severe spinal muscular atrophy. [PDF]
PLoS ONE, 2012 The selective vulnerability of motor neurons to paucity of Survival Motor Neuron (SMN) protein is a defining feature of human spinal muscular atrophy (SMA) and indicative of a unique requirement for adequate levels of the protein in these cells. However,
Andrew J-H Lee +3 more
doaj +1 more source
Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice
Neurobiology of Disease, 2021 Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by survival motor neuron (SMN) protein deficiency which results in motor neuron loss and muscle atrophy. SMA is caused by a mutation or deletion of the survival motor neuron 1 (
Kaitlyn M. Kray +4 more
doaj +1 more source
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons [PDF]
, 2017 Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances
A Gill +49 more
core +2 more sources
A Python based automated tracking routine for myosin II filaments [PDF]
, 2020 The study of motor protein dynamics within cytoskeletal networks is of high interest to physicists and biologists to understand how the dynamics and properties of individual motors lead to cooperative effects and control of overall network behaviour ...
Köster, Darius Vasco +2 more
core +2 more sources
Motion of rotatory molecular motor and chemical reaction rate
, 2003 We examine the dependence of the physical quantities of the rotatory molecular motor, such as the rotation velocity and the proton translocation rate, on the chemical reaction rate using the model based only on diffusion process.
D. Stock +23 more
core +1 more source
On helicases and other motor proteins [PDF]
Current Opinion in Structural Biology, 2008 Helicases are molecular machines that utilize energy derived from ATP hydrolysis to move along nucleic acids and to separate base-paired nucleotides. The movement of the helicase can also be described as a stationary helicase that pumps nucleic acid. Recent structural data for the hexameric E1 helicase of papillomavirus in complex with single-stranded ...
Leemor Joshua-Tor, Eric J. Enemark
openaire +3 more sources
eLife, 2014 X-ray crystallography has revealed an unusual structural element in kinesin-5 motor proteins.
Nikta Fakhri, Christoph F Schmidt
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Protein Synthesis Inhibition in the Peri-Infarct Cortex Slows Motor Recovery in Rats. [PDF]
PLoS ONE, 2016 Neuroplasticity and reorganization of brain motor networks are thought to enable recovery of motor function after ischemic stroke. Especially in the cortex surrounding the ischemic scar (i.e., peri-infarct cortex), evidence for lasting reorganization has
Maximilian Schubring-Giese +3 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source