Results 91 to 100 of about 297,493 (288)

Cognition may link cortical IGFBP5 levels with motor function in older adults.

PLoS ONE, 2019
Alzheimer's disease and related disorders (ADRD) may manifest cognitive and non-cognitive phenotypes including motor impairment, suggesting a shared underlying biology.
Aron S Buchman, Lei Yu, Vladislav A Petyuk, Chris Gaiteri, Shinya Tasaki, Katherine D Blizinsky, Julie A Schneider, Philip L De Jager, David A Bennett   +8 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Directional motility of kinesin motor proteins

, 2000
Kinesin motor proteins are molecules capable of moving along microtubules. They share homology in the so-called core motor domain which acts as a microtubule-dependent ATPase.
Schliwa, Manfred, Woehlke, Günther, Manfred Schliwa, Günther Woehlke   +3 more
core   +1 more source

Competition between microtubule-associated proteins directs motor transport

Nature Communications, 2018
Motor and non-motor microtubule-associated proteins (MAPs) bind to the microtubule lattice, but it is unclear how their binding activities are coordinated and how this impacts motor transport.
Brigette Y. Monroy, Danielle L. Sawyer, Bryce E. Ackermann, Melissa M. Borden, Tracy C. Tan, Kassandra M. Ori-McKenney   +5 more
doaj   +1 more source

ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling

eLife, 2013
Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven ...
Sharon E Torigoe, Ashok Patel, Mai T Khuong, Gregory D Bowman, James T Kadonaga   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Pix proteins and the evolution of centrioles [PDF]

, 2008
We have made a wide phylogenetic survey of Pix proteins, which are constituents of vertebrate centrioles in most eukaryotes. We have also surveyed the presence and structure of flagella or cilia and centrioles in these organisms, as far as is possible ...
Fry, Andrew M., Woodland, Hugh R., Fry Andrew M., H. R. Woodland (7620182), Andrew M Fry, Andrew M. Fry (7589357), Woodland Hugh R., Hugh R Woodland   +7 more
core   +1 more source

Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators

eLife, 2017
The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway
Jutta Nesper, Isabelle Hug, Setsu Kato, Chee-Seng Hee, Judith Maria Habazettl, Pablo Manfredi, Stephan Grzesiek, Tilman Schirmer, Thierry Emonet, Urs Jenal   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa

BMC Research Notes, 2009
Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne, Peters Nick T, Kropf Darryl L   +2 more
doaj   +1 more source