Results 111 to 120 of about 819,058 (310)

Drug discovery and development for Parkinson’s disease: are preclinical models good enough?

Frontiers in Aging Neuroscience
Parkinson’s disease (PD) remains a major challenge for translational neuroscience, with an increasing global prevalence and persistent unmet therapeutic needs.
Alejandro Reinares-Sebastián, Alejandro Reinares-Sebastián, Alejandro Reinares-Sebastián, Noelia Esteban-García, Noelia Esteban-García, Noelia Esteban-García, Masahiko Takada, Masahiko Takada, Inés Trigo-Damas, Inés Trigo-Damas, Inés Trigo-Damas, Inés Trigo-Damas   +11 more
doaj   +1 more source

Motor function and perception in children with neuropsychiatric and conduct problems : results from a population based twin study. [PDF]

, 2014
BACKGROUND: Children with early symptomatic psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) have been found to have high rates of motor and/or perception difficulties.
Anckarsäter, Henrik, Gillberg, Christopher, Gustafsson, Peik,, Kerekes, Nora, Lichtenstein, Paul, Lund University., Råstam, Maria,   +6 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effectiveness and applications of neurologic music therapy in motor and non-motor rehabilitation for older adults with Parkinson’s disease: a systematic review and meta-analysis

Frontiers in Neurology
PurposeTo systematically assess the current status and effectiveness of neurologic music therapy in the rehabilitation of older adults with Parkinson’s disease.Materials and methodsA comprehensive search was conducted for randomized controlled trials ...
Aoyi Li, Yiyao Yang, Qiyu Jiang, Tiantian Wu, Tiantian Li   +4 more
doaj   +1 more source

Association Between Joint Hypermobility Syndrome and Developmental Coordination Disorder – A Review. [PDF]

, 2012
Introduction: The term joint hypermobility syndrome (JHS) was adopted after clinicians became aware of the myriad of symptoms associated with this multisystemic condition.
Clark, Carol J., Khattab, Ahmed D.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review

Dementia & Neuropsychologia
Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment.
Flavia Amaral Machado, Caroline Tozzi Reppold   +1 more
doaj   +1 more source

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Neuropsychiatric Disease and Treatment, 2021
Yu Cao,1,* Gongfeng Li,1,* Jinsheng Xue,2,* Guijuan Zhang,1 Sensen Gao,1 Yuling Huang,1 Aiqin Zhu1 1Institute of Geriatric, Qinghai Provincial People’s Hospital, Xining, People’s Republic of China; 2Foreign Cooperation Office, Chengdu Fifth ...
Cao Y, Li G, Xue J, Zhang G, Gao S, Huang Y, Zhu A   +6 more
doaj  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Non-Motor Off Symptoms in Parkinson's Disease

Journal of Korean Medical Science, 2009
The aim of this study is to elucidate the clinical spectrum and frequency of non-motor symptoms during off periods (NMOS) in Parkinson's disease (PD) patients with motor fluctuation. We compared clinical characteristics between PD patients with motor symptoms only (M-off) and those with both motor and non-motor symptoms (NM-off) during off periods. The
Cheon, Sang-Myung, Park, Min Jeong, Kim, Wook-Joo, Kim, Jae Woo   +3 more
openaire   +2 more sources