Results 1 to 10 of about 3,713,315 (228)

Totipotency in the mouse [PDF]

Journal of Molecular Medicine, 2017
In mammals, the unicellular zygote starts the process of embryogenesis and differentiates into all types of somatic cells, including both fetal and extraembryonic lineages-in a highly organized manner to eventually give rise to an entire multicellular organism comprising more than 200 different tissue types.
Lei Lei, Lei Lei, Guangming Wu, Hans R. Schöler, Hans R. Schöler   +4 more
openaire   +2 more sources

The Mind of a Mouse [PDF]

Cell, 2020
Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the same data-rich sources. Advances in automated mapping of the brain's synaptic connections (connectomics) suggest that the complicated circuits underlying ...
Viren Jain, Terrence J. Sejnowski, Terrence J. Sejnowski, David W. Tank, H. Sebastian Seung, Jeff W. Lichtman, David C. Van Essen, Adrienne L. Fairhall, Bruce R. Rosen, John H. R. Maunsell, Narayanan Kasthuri, Moritz Helmstaedter, Gerald M. Rubin, Larry F. Abbott, Catherine Dulac, Edward M. Callaway, R. Clay Reid, Peter B. Littlewood, Doris Y. Tsao, Yann LeCun, Ila Fiete, Davi D. Bock, Karel Svoboda, Kristen M. Harris, Liqun Luo, Winfried Denk   +25 more
openaire   +5 more sources

A Mouse is Not Just a Mouse

Animal Welfare, 2000
AbstractIn this paper we describe the existence and consequences of subspecific and individual variation in the genetic make-up of house mice. The purpose is to illustrate forms of variation that are often neglected in discussions about animal care and experimental design. Towards this end, different inbred mouse strains as well as genetically selected
Sluyter, F., Oortmerssen, G.A. van
openaire   +4 more sources

Retinal cone photoreceptors of the deer mouse Peromyscus maniculatus : development, topography, opsin expression and spectral tuning [PDF]

, 2013
A quantitative analysis of photoreceptor properties was performed in the retina of the nocturnal deer mouse, Peromyscus maniculatus, using pigmented (wildtype) and albino animals.
Arbogast, Patrick, Glösmann, Martin, Peichl, Leo   +2 more
core   +11 more sources

Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB) [PDF]

, 2009
Many advances in the field of cancer biology have been made using mouse models of human cancer. The Mouse Tumor Biology (MTB, "http://tumor.informatics.jax.org":http://tumor.informatics.jax.org) database provides web-based access to data on ...
Carol J. Bult, Dale A. Begley, Debra M. Krupke, Janan T. Eppig, Joel E. Richardson, John P. Sundberg, Steven B. Neuhauser   +6 more
core   +2 more sources

Cat and Mouse [PDF]

Neuron, 2006
The role of cathepsin B, a lysosomal protease implicated in amyloid-beta (Abeta1-42) metabolism, in Alzheimer's disease remains controversial. In this issue of Neuron, Mueller-Steiner et al. manipulate the expression of cathepsin B in aged APP transgenic mice, observing that increased expression degrades preformed oligomeric and fibrillar amyloid ...
Cole, Greg M., Frautschy, Sally A.
openaire   +2 more sources

Contrasting mechanisms of penile urethral formation in mouse and human. [PDF]

, 2018
This paper addresses the developmental mechanisms of formation of the mouse and human penile urethra and the possibility that two disparate mechanisms are at play.
Baskin, Laurence, Cunha, Gerald R, Liu, Ge, Liu, Xin, Shen, Joel, Sinclair, Adriane   +5 more
core   +2 more sources

The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. [PDF]

, 2016
The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS).
Chechneva, Olga, Daugherty, Daniel J, Deng, Wenbin, Mayrhofer, Florian   +3 more
core   +1 more source

Mouse versus Rat: Profound Differences in Meiotic Regulation at the Level of the Isolated Oocyte [PDF]

, 2011
Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed ...
Biggers, Brannstrom, Chen, Chen, Cho, Dekel, Dekel, Dekel, Dekel, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Eppig, Fagbohun, Fagbohun, Han, Hubbard, LaRosa, LaRosa, Larsen, Magnusson, Makris, Masciarelli, Mouse Genome Sequencing Consortium, Mullins, Norris, Norris, Norris, Racowsky, Rat Genome Sequencing Project Consortium, Ratner, Ratner, Reizel, Richard, Romero, Schultz, Sela-Abramovich, Sela-Abramovich, Sela-Abramovich, Shitsukawa, Tornell, Tornell, Tornell, Tornell, Tornell, Tsafriri, Tsafriri, Vaccari, Vivarelli, Zeilmaker, Zhang, Zhang, Zhang, Zhao   +61 more
core   +2 more sources

Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome [PDF]

, 2007
Background: Transposed elements (TEs) have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome and the mouse transcriptome.
Ast, Gil, Gal-Mark, Nurit, Lev-Maor, Galit, Mersch, Britta, Sela, Noa, Wagenblatt, Agnes Hotz-   +5 more
core   +3 more sources