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Author Correction: Study of mouse behavior in different gravity environments
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Michihiko Shimomura +7 more
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Study of mouse behavior in different gravity environments
Scientific Reports, 2021 Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study,
Michihiko Shimomura +7 more
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Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring
Translational Psychiatry, 2021 Maternal environmental exposures, such as high-fat diets, diabetes and obesity, can induce long-term effects in offspring. These effects include increased risk of neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), depression ...
Darren J. Fernandes +7 more
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Cell, 2020 Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the same data-rich sources. Advances in automated mapping of the brain's synaptic connections (connectomics) suggest that the complicated circuits underlying ...
Viren Jain +25 more
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Totipotency in the mouse [PDF]
Journal of Molecular Medicine, 2017 In mammals, the unicellular zygote starts the process of embryogenesis and differentiates into all types of somatic cells, including both fetal and extraembryonic lineages-in a highly organized manner to eventually give rise to an entire multicellular organism comprising more than 200 different tissue types.
Lei Lei +4 more
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Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
Nature Communications, 2020 Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates ...
Gianluca Fulgenzi +11 more
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Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour
Scientific Reports, 2022 Protocadherin 9 (Pcdh9) is a member of the cadherin superfamily and is uniquely expressed in the vestibular and limbic systems; however, its physiological role remains unclear.
Masato Uemura +12 more
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Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty
Cells, 2023 The spreading of senescent cells’ burden holds profound implications for frailty, prompting the exploration of novel therapeutic targets. In this perspective review, we delve into the intricate mechanisms underlying senescent cell spreading, its ...
Serena Marcozzi +6 more
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Molecular Autism, 2017 Background Rett syndrome (RTT) is a neurodevelopmental disorder that predominantly affects girls. The majority of RTT cases are caused by de novo mutations in methyl-CpG-binding protein 2 (MECP2), and several mouse models have been created to further ...
Rylan Allemang-Grand +6 more
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Nature Communications, 2022 Mishra et al. have generated mice with a single amino acid substitution in BRCA2, which disrupts its interaction with DSS1 resulting in a severe HR defect. They show the interaction to be dispensable for HR at replication induced and meiotic DSBs.
Arun Prakash Mishra +15 more
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