Results 11 to 20 of about 4,395,352 (325)
Retinal cone photoreceptors of the deer mouse Peromyscus maniculatus : development, topography, opsin expression and spectral tuning [PDF]
, 2013 A quantitative analysis of photoreceptor properties was performed in the retina of the nocturnal deer mouse, Peromyscus maniculatus, using pigmented (wildtype) and albino animals.
Arbogast, Patrick +2 more
core +14 more sources
Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB) [PDF]
, 2009 Many advances in the field of cancer biology have been made using mouse models of human cancer. The Mouse Tumor Biology (MTB, "http://tumor.informatics.jax.org":http://tumor.informatics.jax.org) database provides web-based access to data on ...
Carol J. Bult +6 more
core +2 more sources
Animal Welfare, 2000 AbstractIn this paper we describe the existence and consequences of subspecific and individual variation in the genetic make-up of house mice. The purpose is to illustrate forms of variation that are often neglected in discussions about animal care and experimental design. Towards this end, different inbred mouse strains as well as genetically selected
Sluyter, F., Oortmerssen, G.A. van
openaire +4 more sources
Neuron, 2006 The role of cathepsin B, a lysosomal protease implicated in amyloid-beta (Abeta1-42) metabolism, in Alzheimer's disease remains controversial. In this issue of Neuron, Mueller-Steiner et al. manipulate the expression of cathepsin B in aged APP transgenic mice, observing that increased expression degrades preformed oligomeric and fibrillar amyloid ...
Cole, Greg M., Frautschy, Sally A.
openaire +2 more sources
Contrasting mechanisms of penile urethral formation in mouse and human. [PDF]
, 2018 This paper addresses the developmental mechanisms of formation of the mouse and human penile urethra and the possibility that two disparate mechanisms are at play.
Baskin, Laurence +5 more
core +2 more sources
Brain Sciences, 2021 Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova +12 more
doaj +1 more source
The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. [PDF]
, 2016 The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS).
Chechneva, Olga +3 more
core +1 more source
Breast Cancer Research, 2020 Next-generation sequencing of Sri Lankan families with inherited cancer syndromes resulted in the identification of five BRCA2 variants of unknown clinical significance.
Nirmala Sirisena +7 more
doaj +1 more source
npj Genomic Medicine, 2020 Sequencing-based genetic tests to identify individuals at increased risk of hereditary breast and ovarian cancers have resulted in the identification of more than 40,000 sequence variants of BRCA1 and BRCA2. A majority of these variants are considered to
Kajal Biswas +9 more
doaj +1 more source
TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
Translational Psychiatry, 2022 Recent studies have suggested that the use of cognitive enhancers as adjuncts to exposure-based therapy in individuals suffering from post-traumatic stress disorder (PTSD) may be beneficial. Brain cholinergic signaling through basal forebrain projections
Sudhirkumar Yanpallewar +7 more
doaj +1 more source