Results 21 to 30 of about 4,518,026 (355)
Pontin is essential for murine hematopoietic stem cell survival
Haematologica, 2012 Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression.
Oxana Bereshchenko +5 more
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TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
Translational Psychiatry, 2022 Recent studies have suggested that the use of cognitive enhancers as adjuncts to exposure-based therapy in individuals suffering from post-traumatic stress disorder (PTSD) may be beneficial. Brain cholinergic signaling through basal forebrain projections
Sudhirkumar Yanpallewar +7 more
doaj +1 more source
Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease
EMBO Molecular Medicine, 2014 The recent precipitous rise in autoimmune diseases is placing an increasing clinical and economic burden on health systems worldwide. Current therapies are only moderately efficacious, often coupled with adverse side effects.
Daniel Bilbao +4 more
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Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
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Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells
Scientific Reports, 2017 Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders.
Yixing Han +5 more
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Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Nature Communications, 2016 The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Xia Ding +20 more
doaj +1 more source
Developmental Changes in the ECG of a Hamster Model of Muscular Dystrophy and Heart Failure
Frontiers in Pharmacology, 2012 Aberrant autonomic signaling is being increasingly recognized as an important symptom in neuromuscular disorders. The delta-sarcoglycan-deficient BIO TO-2 hamster is recognized as a good model for studying mechanistic pathways and sequelae in muscular ...
Thomas Gerard Hampton +4 more
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Cancer cell survival depends on collagen uptake into tumor-associated stroma
Nature Communications, 2022 Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu +21 more
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Insulin Resistance: From Mechanisms to Therapeutic Strategies [PDF]
Diabetes & Metabolism Journal, 2022 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee +2 more
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Disease Models & Mechanisms, 2021 In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown.
Anum Rahman +8 more
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