Results 21 to 30 of about 4,395,352 (325)
Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome [PDF]
, 2007 Background: Transposed elements (TEs) have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome and the mouse transcriptome.
Ast, Gil +5 more
core +3 more sources
BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
Nature Communications, 2018 Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.
Kajal Biswas +9 more
doaj +1 more source
Pontin is essential for murine hematopoietic stem cell survival
Haematologica, 2012 Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression.
Oxana Bereshchenko +5 more
doaj +1 more source
Mouse versus Rat: Profound Differences in Meiotic Regulation at the Level of the Isolated Oocyte [PDF]
, 2011 Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed ...
Biggers +61 more
core +2 more sources
Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease
EMBO Molecular Medicine, 2014 The recent precipitous rise in autoimmune diseases is placing an increasing clinical and economic burden on health systems worldwide. Current therapies are only moderately efficacious, often coupled with adverse side effects.
Daniel Bilbao +4 more
doaj +1 more source
Insulin Resistance: From Mechanisms to Therapeutic Strategies [PDF]
Diabetes & Metabolism Journal, 2022 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee +2 more
doaj +1 more source
Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells
Scientific Reports, 2017 Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders.
Yixing Han +5 more
doaj +1 more source
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Nature Communications, 2016 The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Xia Ding +20 more
doaj +1 more source