Results 21 to 30 of about 3,713,315 (228)

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

The orienting mouse: An input device with attitude [PDF]

, 2013
This paper presents a modified computer mouse, the Orienting Mouse, which delivers orientation as an additional dimension of input; when the mouse is moved on a flat surface it reports, in addition to the conventional x, y translation, angular rotation ...
Apperley, Mark, Rogers, Bill
core   +1 more source

Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells [PDF]

, 2006
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus
Anderson, Araibi, Ashrafi, Ashrafi, Barbara Marchetti, Brad Ozanne, Burnett, Campo, Carragher, DiMaio, Emmanuella Tsirimonaki, Faccini, Fackler, Frame, Frame, Frame, Frame, G. Hossein Ashrafi, Geiger, Hennigan, Jackson, Jaggar, Jarrett, Kasper, Lu, Lynn McGarry, M. Saveria Campo, Marchetti, Nobes, Nunbhakdi-Craig, O’Brien, O’Brien, O’Brien, Pennie, Robina Ullah, Schapiro, Schiller, Scott, Suprynowicz, zur Hausen   +39 more
core   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Mouse models and mouse supermodels

EMBO Molecular Medicine, 2010
Varnat et al, EMBO Mol Med, 1, 338–351, report that Hedgehog (HH) signalling is essential for growth of human colon carcinoma (CC) (Varnat et al, 2009). In the accompanying Closeup article (Gulino et al, 2009) state that while participation of the HH pathway in CC has been controversial because of conflicting and contradictory data (Varnat et al, 2009)
openaire   +2 more sources

An encyclopedia of mouse DNA elements (Mouse ENCODE) [PDF]

Genome Biology, 2012
To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the same experimental pipelines developed for human ENCODE to annotate the mouse genome.
Meagan Fastuca, Weisheng Wu, Christopher T. Morrissey, Kate R. Rosenbloom, Deepti Jain, Sonali Jha, Thomas R. Gingeras, W. James Kent, Feng Yue, Ali Mortazavi, Gregory E. Crawford, Theresa K. Canfield, Philip Cayting, M. A. Bender, Rachel Byron, Venkat S. Malladi, Sarah Djebali, Marta Byrska-Bishop, Sherman M. Weissman, Michael Snyder, Michael J. Pazin, Diane Trout, Alexander Dobin, Jin Lian, Georgi K. Marinov, John A. Stamatoyannopoulos, Lee Edsall, Rebecca F. Lowdon, Vaughan Roach, Gayathri Balasundaram, Zhen Ye, Rajinder Kaul, Wulan Deng, Samantha Kuan, Yin Shen, Mia Zhang, Melissa S. Cline, Mark Groudine, Mitchell J. Weiss, Peter J. Good, James Taylor, Vanessa M. Kirkup, Zhihai Ma, Kaun-Bei Chen, Gerd A. Blobel, Katherine I. Fisher-Aylor, A Sandra Stehling, Brian A. Williams, Stephen G. Landt, Wei Lin, Manoj Hariharan, Daniel Blankenberg, Max Pimkin, Erica Giste, Tejaswini Mishra, Elise A. Feingold, Anthony Kiralusha, David McCleary, Richard Sandstrom, Takayo Sasaki, Henry Amrhein, Katrina Learned, Olgert Denas, Chris Zaleski, Leslie B Adams, Ross C. Hardison, Yong Cheng, Huaien Wang, Job Dekker, Robert E. Thurman, Gilberto DeSalvo, Swathi Ashok Kumar, Bing Ren, Amartya Sanyal, Carrie A. Davis, Audra K. Johnson, Julien Lagarde, Cheryl A. Keller, Chenghai Xue, David M. Gilbert, Tyrone Ryba, Gaurav Jain, Peter J. Sabo, Roderic Guigó, Bryan R. Lajoie, Barbara J. Wold   +85 more
openaire   +6 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 [PDF]

, 2018
CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic ...
Alarcon, Balbino, Borroto, Aldo, Campese, Antonio F., Caristi, Silvana, Favre, Cédric, Grazioli, Paola, Kunkl, Martina, Mastrogiovanni, Marta, Muscolini, Michela, Nunès, Jacques A., Porciello, Nicla, Screpanti, Isabella, Spadaro, Francesca, Tuosto, Loretta   +13 more
core   +4 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Mouse X [PDF]

, 2012
Mouse X is a short science fiction film which was shot in August 2012 and is a mystery/sci-fi story about Anderson, a man who wakes in a building with no idea where he is or how he got there, before slowly discovering that in each of the rooms around him
Tagg, Justin, Tagg, Justin
core