Results 31 to 40 of about 60,701 (176)
Mouse Mammary Tumor Virus c-rel Transgenic Mice Develop Mammary Tumors [PDF]
Molecular and Cellular Biology, 2003 Amplification, overexpression, or rearrangement of the c-rel gene, encoding the c-Rel NF-kappaB subunit, has been reported in solid and hematopoietic malignancies. For example, many primary human breast cancer tissue samples express high levels of nuclear c-Rel. While the Rev-T oncogene v-rel causes tumors in birds, the ability of c-Rel to transform in
Raphaëlle, Romieu-Mourez +7 more
openaire +2 more sources
Infectious Agents and Cancer, 2017 Background Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast cancer. Here we demonstrate that these
James S. Lawson, Wendy K. Glenn
doaj +1 more source
Breast Cancer: Basic and Clinical Research, 2020 Background: Viral cause of sporadic breast cancer (SBC) has been suggested based on the experimental murine model of mammary tumor caused by mouse mammary tumor virus (MMTV), Epstein-Barr virus (EBV), and human papillomavirus (HPV).
Mohammad Al Hamad +9 more
doaj +1 more source
A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]
PLoS ONE, 2017 This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc +5 more
doaj +1 more source
Effect of trypsin on mouse mammary tumor virus [PDF]
Journal of Virology, 1976 Undisrupted mouse mammary tumor virus (MuMTV) derived from the milk of of RIII mice has been analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electron microscopy after treatment with insolubilized trypsin. No alterations were found in viral fine structure by either freeze-etch or negative-stain electron microscopy.
Sheffield, J B +3 more
openaire +2 more sources
Molecular Imaging, 2007 Vascular endothelial growth factor (VEGF) is a major inducer of angiogenesis. We generated a transgenic reporter mouse, VEGF-GL, in which an enhanced green fluorescent protein-luciferase fusion protein is expressed under the control of a human VEGF-A ...
Shannon L. Faley +7 more
doaj +1 more source
The Role of a Betaretrovirus in Human Breast Cancer: Enveloping a Conundrum
Viruses, 2022 Most of the evidence that a human betaretrovirus (HBRV/HMTV) highly related to mouse mammary tumour virus (MMTV) has an etiological role in breast cancer has been summarized in a recent comprehensive Special Issue of “Viruses” entitled “Human ...
Walter H. Gunzburg, Brian Salmons
doaj +1 more source
Polyprotein Precursors to Mouse Mammary Tumor Virus Proteins [PDF]
Journal of Virology, 1979 Mouse mammary tumor virus (MMTV) derived from the culture medium of GR cells contained seven proteins, identified as gp55, gp33, p25, pp20, p16, p12, and p10. The major viral phosphoprotein was the 20,000-molecular-weight protein, pp20. Immunoprecipitation of cytoplasmic extracts from pulse-labeled GR cells identified three MMTV
Anderson, S J +3 more
openaire +2 more sources
PLoS ONE, 2017 CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer.
Robin M H Rumney +5 more
doaj +1 more source
Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models
The Journal of Clinical Investigation, 2023 The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement in tumorigenesis has remained ...
Raman Devarajan +18 more
doaj +1 more source