Results 91 to 100 of about 5,512 (205)

T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination [PDF]

In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigated.

core   +4 more sources

Advancing the understanding and management of Mpox: insights into epidemiology, disease pathways, prevention, and therapeutic strategies [PDF]

Mpox, previously known as monkeypox, is a zoonotic viral disease caused by the Mpox virus (MPXV), a member of the Orthopoxvirus genus. This disease is of significant concern due to its zoonotic transmission, which can be challenging to control, its ...
Abusara, Osama H., Bardaweel, Sanaa K., Hajjo, Rima, Sabbah, Dima A.   +3 more
core   +2 more sources

The Impact of Monkeypox Virus Infection on Pregnancy Outcome: Clinical Features and Potential Pathogenic Mechanisms

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Monkeypox has garnered significant attention following its emergence in multiple countries and its designation as a global health emergency in 2022. There is a notable deficiency in clinical and experimental data regarding pregnancy outcomes following monkeypox infection.
Jingyi Wu, Fangbin Huang, Qingliang Zheng, Poorani Gurumallesh   +3 more
wiley   +1 more source

Characterization of the Monkeypox Virus [MPX]-Specific Immune Response in MPX-Cured Individuals Using Whole Blood to Monitor Memory Response [PDF]

Background: Monkeypox (Mpox) is a zoonotic disease caused by monkeypox virus (MPXV), an Orthopoxvirus (OPXV). Since we are observing the first MPXV outbreak outside the African continent, the general population probably does not have a pre-existing ...
Cuzzi G., De Marco P., Goletti D., Grifoni A., Maggi F., Matusali G., Navarra A., Nicastri E., Petruccioli E., Pierelli L., Salmi A., Sbarra S., Sette A., Vita S.   +13 more
core   +1 more source

Applying improved ddPCR to reliable quantification of MPXV in clinical settings

Microbiology Spectrum
ABSTRACT Monkeypox virus (MPXV) poses a global health threat. Droplet digital PCR (ddPCR) holds potential as an accurate diagnostic tool for clinical microbiology. However, there is limited literature on the applicability of ddPCR in clinical settings. In this study, the clinical features of patients with MPXV during
Chudan Liang, Huiqin Yang, Xiaofeng Yang, Zhenyu Long, Yuandong Zhou, Jian Wang, Linjin Fan, Mou Zeng, Yulong Wang, Haipeng Zheng, Zequn Wang, Pengfei Ye, Jingyan Lin, Wendi Shi, Hongxin Huang, Huijun Yan, Jun Qian, Linghua Li, Linna Liu   +18 more
openaire   +3 more sources

Mpox virus OPG175 negatively regulates viral replication by controlling Wnt signaling

iScience
Summary: Mpox virus (MPXV) infection exhibits different case fatality rates and symptoms depending on its clade. However, there has been insufficient molecular biological analysis of the differences between clades.
Yoshitaka Nakata, Masako Yamasaki, Yukio Watanabe, Keiya Uriu, Rina Hashimoto, Takuya Yamamoto, Kei Sato, Akatsuki Saito, Kazuo Takayama   +8 more
doaj   +1 more source

MPXV Sequencing from Wastewater (ONT) V1.0 v1

This protocol is designed to sequence MPXV from wastewater samples using a limited amplicon scheme that targets all MPXV clades, subclades, and lineages.
Allison Steedman, Mark Zeller
openaire   +1 more source

Modelling the potential spread of Clade Ib MPXV in Asian cities

BMJ Public Health
Background The ongoing 2023–2024 mpox outbreak in several African countries, driven by the novel Clade Ib strain, has resulted in imported cases being reported in Sweden, Thailand and India. The potential high transmissibility of this new strain and shifts in transmission modes may make territories in Asia ...
Shihui Jin, Gregory Gan, Akira Endo, Kiesha Prem, Rayner Kay Jin Tan, Jue Tao Lim, Keisuke Ejima, Borame L Dickens   +7 more
openaire   +3 more sources

Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen

Communications Biology
Despite the recent mpox outbreak raising global concerns, no fully validated antiviral treatment exists, highlighting the urgent need for effective therapeutics.
Daisuke Akazawa, Masayuki Shimojima, Eun-Sil Park, Akiko Okutani, Milagros Virhuez-Mendoza, Yusuke Inoue, Takayuki Hishiki, Ken Maeda, Hideki Ebihara, Yoshimasa Takahashi, Koichi Watashi   +10 more
doaj   +1 more source

Characterization of a plant-derived monoclonal antibody targeting extracellular enveloped virions of Monkeypox virus

Frontiers in Plant Science
In 2022, the global outbreak of monkeypox virus (MPXV) with increased human-to-human transmission triggered urgent public health interventions. Plant-derived monoclonal antibodies (mAbs) are being explored as potential therapeutic strategies due to their
Jennifer A. Melendez, Jennifer A. Melendez, Haiyan Sun, James Bonner, James Bonner, Qiang Chen, Qiang Chen   +6 more
doaj   +1 more source