Results 111 to 120 of about 5,512 (205)

Mpox (Monkeypox) Virus and Its Co-Infection with HIV, Sexually Transmitted Infections, or Bacterial Superinfections: Double Whammy or a New Prime Culprit?

Viruses
Epidemiologic studies have established that mpox (formerly known as monkeypox) outbreaks worldwide in 2022–2023, due to Clade IIb mpox virus (MPXV), disproportionately affected gay, bisexual, and other men who have sex with men.
Benjamin M. Liu, Natella Y. Rakhmanina, Zhilong Yang, Michael I. Bukrinsky   +3 more
doaj   +1 more source

The Generation and Characterization of Monoclonal Antibodies against the MPXV A29L Protein

Viruses
Mpox (formerly known as monkeypox) is a zoonotic disease caused by monkeypox virus (MPXV), a DNA virus belonging to the Orthopoxvirus genus, in the Poxviridae family. The disease constitutes a moderate risk to public health at the global level. The MPXV A29L protein plays a crucial role in coordinating virion assembly and facilitating important virus ...
Wenlong Zhu, Mengjia Zhang, Mengdi Zhang, Ran Jing, Jiaru Zhou, Hua Cao, Changcheng Liu, Hongmei Zhu, Ahmed H. Ghonaim, Sherin R. Rouby, Wentao Li   +10 more
openaire   +3 more sources

Development of a multiplex real-time PCR for the simultaneous detection of monkeypox virus clades I, II, and goatpox virus

Frontiers in Veterinary Science
IntroductionMonkeypox virus (MPXV) hosts are of multiple species, with a risk of cross-species transmission. This phenomenon poses a threat to unreported affected domestic animals and increases the risk to human public health.
Yongqiang Lin, Zijing Guo, Jinsong Chen, Xianwen Zhang, Long Zhou, Yanmin Li, Zhidong Zhang   +6 more
doaj   +1 more source

Mpox multiprotein virus-like nanoparticle vaccine induces neutralizing and protective antibodies in mice and non-human primates [PDF]

The upsurge of mpox in Africa and the recent global outbreak have stimulated the development of new vaccines and therapeutics. We describe the construction of virus-like particle (VLP) vaccines in which modified M1, A35 and B6 proteins from monkeypox ...
Belghith, Ahmed A., Brenchley, Jason M., Cotter, Catherine A., Earl, Patricia L., Hills, Rory A., Howarth, Mark R., Ignacio, Maxinne A., Moss, Bernard, Yee, Debra S.   +8 more
core   +2 more sources

Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

Communications Medicine
Background Although the mpox global health emergency caused by mpox virus (MPXV) clade IIb.1 has ended, mpox cases are still reported due to low vaccination coverage and waning immunity.
Flavia Chiuppesi, John A. Zaia, Miguel-Angel Gutierrez-Franco, Sandra Ortega-Francisco, Minh Ly, Mindy Kha, Taehyun Kim, Shannon Dempsey, Swagata Kar, Alba Grifoni, Alessandro Sette, Felix Wussow, Don J. Diamond   +12 more
doaj   +1 more source

Human outbreak detection and best practice MPXV analysis and interpretation with squirrel. [PDF]

Virus Evol
Abstract High numbers of reported mpox cases and recent identification of multiple sustained human outbreaks of MPXV have highlighted the need for robust, best-practice genomic surveillance tools. In light of the SARS-CoV-2 pandemic, many labs across the globe developed the capacity to do virus genome sequencing, however MPXV presents ...
O'Toole Á, Kinganda-Lusamaki E, Colquhoun R, Chato C, Scher E, Kent C, Wilkinson S, Quick J, Loman N, Duggan AT, Mbala P, Rambaut A.   +11 more
europepmc   +2 more sources

Impaired Cellular Immunity and Cross‐Reactive Humoral Responses to Mpox Virus in HIV‐Infected Individuals Vaccinated with Vaccinia Virus Tiantan Strain [PDF]

In the global response to the current mpox epidemic, understanding immune memory to the vaccinia virus and cross‐immunity to the mpox virus (MPXV) among people living with HIV (PLWH) is critical.
Antoun, Elie, Chen, Lan, Chen, Xiaoyou, Chi, Xueqi, Dong, Tao, Fang, Meiyu, Gu, Zhixia, Guo, Fei, Guo, Li, Han, Ning, Huang, Yu, Jin, Ronghua, Li, Danyang, Li, Yanan, Peng, Yanchun, Ren, Lili, Song, Rui, Wang, Jianwei, Xu, Fengwen, Zhang, Qiao, Zhang, Yuanyuan, Zhao, Hongxin, Zhong, Jingchuan   +22 more
core   +2 more sources

Presumed Transmission of 2 Distinct Monkeypox Virus Variants from Central African Republic to Democratic Republic of the Congo. [PDF]

We linked 4 mpox cases in South Ubangi, Democratic Republic of the Congo, to transboundary transmission from Central African Republic. Viral genome sequencing demonstrated that the monkeypox virus sequences belonged to distinct clusters of subclade Ia ...
Anta, Yvon, Ayouba, Ahidjo, Aziza, Adrienne, Bolunza, Pierrot, Boum, Yap, Cigolo, Jean, Delaporte, Eric, Halbrook, Megan, Hensley, Lisa, Hoff, Nicole, Kabamba, Gabriel, Kalonji, Thierry, Kalthan, Ernest, Kanda, Innocent, Kasongo, Francois, Kindrachuk, Jason, Kinganda-Lusamaki, Eddy, Liesenborghs, Laurens, Linsuke, Sylvie, Low, Nicola, Lumembe, Raphael, Lunyanga, Lygie, Madinga, Joule, Malembi, Emile, Matoka, Patricia, Mbala-Kingebeni, Placide, Merritt, Sydney, Mundeke, Steve, Mwamba, Dieudonné, Nakoune, Emmanuel, Ngandu, Christian, Ngazobo, Raoul, Nsio, Justus, Peeters, Martine, Pukuta, Elisabeth, Rimoin, Anne, Shaw, Souradet, Shongo, Robert, Tamfum, Jean-Jacques, Vakaniaki, Emmanuel   +39 more
core   +1 more source

Genomic variability and immunological aspects involved in response to MPXV infection

Frontiers in Pharmacology
Mpox, caused by the monkeypox virus (MPXV), is a zoonotic disease that has gained global relevance after the 2022–2024 outbreak. MPXV exists in two distinct clades: clade I, associated with higher virulence and mortality, and clade II, which demonstrated increased human-to-human transmission and adaptation.
La Frazia, Simone, Garbuglia, Anna Rosa, Pauciullo, Silvia, Zulian, Verdiana, Del Porto, Paola   +4 more
openaire   +1 more source

Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development

Infectious Diseases of Poverty
Background The monkeypox virus (MPXV) has raised global health concerns due to its widespread transmission. This study evaluated the MPXV immunogenic antigens and the impact of vaccinia virus (VACV) vaccination and MPXV infection on cross-reactive ...
Jing Liu, Xun Wang, Yiting Zhang, Changyi Liu, Meng Zhang, Chen Li, Peiling Liu, Shanshan Li, Kaifeng Wei, Yiming Cai, Hongjie Yu, Zhiliang Hu, Pengfei Wang, Yanliang Zhang   +13 more
doaj   +1 more source