Results 121 to 130 of about 5,512 (205)

Characterization of Monkeypox virus dissemination in the black-tailed prairie dog (Cynomys ludovicianus) through in vivo bioluminescent imaging.

PLoS ONE, 2019
Monkeypox virus (MPXV) is a member of the genus Orthopoxvirus, endemic in Central and West Africa. This viral zoonosis was introduced into the United States in 2003 via African rodents imported for the pet trade and caused 37 human cases, all linked to ...
Zachary P Weiner, Johanna S Salzer, Elizabeth LeMasters, James A Ellison, Ashley V Kondas, Clint N Morgan, Jeffery B Doty, Brock E Martin, Panayampalli Subbian Satheshkumar, Victoria A Olson, Christina L Hutson   +10 more
doaj   +1 more source

Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity

Virology Journal
The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes
Yahya A. Almutawif, Haydar M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Hamza M. A. Eid, Athanasios Alexiou, Marios Papadakis, Mohammed E. Abo‑El Fetoh, Gaber El-Saber Batiha   +8 more
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First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo [PDF]

Background: The ongoing mpox outbreaks in the Democratic Republic of the Congo (DRC) resulted in >71,000 suspected cases from 01 January 2024 to 02 February 2025.
Ahuka-Mundeke, Steve, Akil-Bandali, Prince, Amuri-Aziza, Adrienne, Ayouba, Ahidjo, Birindwa-Hamisi, Yves, Bodisa-Matamu, Tavia, Delaporte, Eric, Ebondo, Amos Kiuka, Halbrook, Megan, Hensley, Lisa E., Hoff, Nicole A., Jansen, Daan, Kacita, Cris, Kavira-Bapitani, Sifa, Kavira-Kamaliro, Adèle, Kavunga, Hugo, Kindrachuk, Jason, Kinganda-Lusamaki, Eddy, Liesenborghs, Laurens, Lokilo-Lofiko, Emmanuel, Loman, Nicholas, Low, Nicola, Luakanda-Ndelemo, Gradi, Maboko, Gaston Lubambo, Makangara-Cigolo, Jean-Claude, Mangolopa, Alain Kakule, Mbala-Kingebeni, Placide, Merritt, Sydney, Modadra-Madakpa, Brigitte, Mufungizi, Jeriel, Muhindo-Milonde, Emile, Mukadi-Bamuleka, Daniel, Mulopo-Mukanya, Noella, Mutombo-Ndongala, Guy, Muyembe-Tamfum, Jean-Jacques, Ngimba, Michel, Nundu, Sabin Sabiti, O’Toole, Áine, Paluku-Kalimuli, Zephanie, Peeters, Martine, Pilarowski, Genay, Pukuta-Simbu, Elisabeth, Rambaut, Andrew, Rimoin, Anne W., Shaw, Souradet Y., Shongo, Robert, Subissi, Lorenzo, Tessema, Sofonias Kifle, Tshiani, Olivier, Vakaniaki, Emmanuel Hasivirwe, Vercauteren, Koen, Wawina-Bokalanga, Tony, Wilkinson, Sam   +52 more
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Epidemiology and phylogenomic characterisation of two distinct mpox outbreaks in Kinshasa, DR Congo, involving a new subclade Ia lineage: a retrospective, observational study [PDF]

Background: Clade I monkeypox virus is endemic in DR Congo. We aim to describe the epidemiological trends of the cocirculating subclades Ia and Ib mpox outbreaks in Kinshasa, DR Congo.
Ahuka-Mundeke, Steve, Akil-Bandali, Prince, Amuri-Aziza, Adrienne, Ayouba, Ahidjo, Dantas, Pedro H\ L F, De Block, Tessa, Delaporte, Eric, Halbrook, Megan, Hasivirwe Vakaniaki, Emmanuel, Hensley, Lisa E, Hoff, Nicole A, Jansen, Daan, Kacita, Cris, Kelvin, David J, Kindrachuk, Jason, Kinganda-Lusamaki, Eddy, Kwete-Mbokama, Papy, Liesenborghs, Laurens, Lokilo-Lofiko, Emmanuel, Low, Nicola, Luakanda-Ndelemo, Gradi, Makangara-Cigolo, Jean-Claude, Mapenzi-Kashali, Nelson, Mauro Rezende, Antonio, Mbala-Kingebeni, Placide, Merritt, Sydney, Muswamba-Kayembe, Chloé, Muyembe-Tamfum, Jean-Jacques, Mwamba, Dieudonné, O'Toole, Áine, Ola-Mpumbe, Rilia, Paku-Tshambu, Princesse, Peeters, Martine, Ponga-Museme, Ange, Pratt, Catherine, Pukuta-Simbu, Elisabeth, Rambaut, Andrew, Rimoin, Anne W, Subissi, Lorenzo, Tessema, Sofonias, Tshiani-Mbaya, Olivier, Vercauteren, Koen, Wawina-Bokalanga, Tony   +42 more
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ISG15 Differentially Modulates Clade Ib and II MPXV Infection

Abstract The unprecedented human-to-human transmission of Clade IIb monkeypox virus (MPXV) during the 2022 outbreak has renewed focus on host determinants of viral fitness. Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein with broad immunomodulatory functions, yet its role in MPXV infection remains unclear.
Susana Guerra, Joseph McGrail, Irene Campaña Gómez, Antti Tuhkala, Salla Keskitalo, Markku Varjosalo, Adolfo Garcia-Sastre, Gustavo Palacios, Mari Sánchez-Seco   +8 more
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Differential replication, pathology, and immune response of clade IIb mpox virus in C57BL/6 and BALB/c mice

Emerging Microbes and Infections
We have previously established a clade IIb mpox virus (MPXV) pathogenic BALB/c mouse model for developing mpox countermeasures. Here, we comprehensively investigated the susceptibility of BALB/c and C57BL/6 mice to MPXV and found that Clade IIb MPXV was ...
Meimei Duan, Xiangmei Zhang, Xian Tang, Zhuohuan Li, Wenqi Huang, Qi Chen, Mingxia Zhang, Lin Cheng, Zheng Zhang   +8 more
doaj   +1 more source

Immune response to MVA-BN vaccination for Mpox : current evidence and future directions [PDF]

Funding: This work was supported by Health Research Board (grant number MONKEYVAX-2022-1) and by Global Health EDCTP3 (grant number 101195540—MpoxVax AFRIVAC).The 2022 global mpox outbreak, caused by clade IIb of the monkeypox virus (MPXV), prompted ...
Byrne, Joanne, Feeney, Eoin R., Gautier, Virginie, Katoto, Patrick D. M. C., Kirenga, Bruce, Mallon, Patrick W. G., Obuku, Andrew, Sabiiti, Wilber   +7 more
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Clinical Manifestations of an Outbreak of Monkeypox Virus in Captive Chimpanzees in Cameroon, 2016 [PDF]

Monkeypox virus (MPXV) is a re-emerging virus of global concern. An outbreak of Clade I MPXV affected 20 captive chimpanzees in Cameroon in 2016. We describe the epidemiology, virology, phylogenetics, and clinical progression of this outbreak.
Brien, Stephanie C, Doty, Jeffrey B, Feussom, Jean Marc K, LeBreton, Matthew, Matheny, Audrey, Mauldin, Matthew R, McCollum, Andrea M, Missoup, Alain D, Morgan, Clint N, Mouiche, Moctar M M, Nkom, Felix, Nwobegahay, Julius, Pieracci, Emily G, Ritter, Jana M, Tafon, Bibila G, Takuo, Jean Michel, Tamoufe, Ubald, Wade, Abel, Wilkins, Kimberly   +18 more
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Differential susceptibility of immunodeficient mice to MPXV infection and the impact of various inoculation routes

Virologica Sinica
Monkeypox virus (MPXV), a member of the Orthopoxvirus genus, caused a large-scale global outbreak in 2022. Developing mouse models for MPXV infection is crucial for advancing research on vaccines and therapeutic interventions. To address this, we conducted a comparative study on the susceptibility of six mouse strains-severe combined immune-deficiency (
Xiaohan Wang, Shaowen Shi, Xiaoxuan Nie, Yongyang Sun, Jinglei Hu, Manlin He, Wenhao Ren, Yuxing Wang, Zhendong Guo, Gonghe Li, Changbo Ou, Xiao Li, Zongzheng Zhao   +12 more
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The pathogenicity and multi-organ proteomic profiles of Mpox virus infection in SIVmac239-infected rhesus macaques

Nature Communications
Mpox poses a heightened risk of severe disease and mortality among individuals with HIV, yet the molecular mechanisms and immunopathology underlying multi-organ damage caused by the mpox virus (MPXV), particularly in the context of HIV co-infection ...
Dong Zhang, Jiangfeng Liu, Lin Zhu, Baoying Huang, Zhe Cong, Na Li, Jingjing Zhang, Ting Chen, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Chenbo Yang, Wanjun Peng, Qiang Wei, Wenjie Tan, Juntao Yang, Jing Xue   +16 more
doaj   +1 more source