Results 131 to 140 of about 5,512 (205)

Genetic Variability of Monkeypox Virus and Its Implications for Human Disease [PDF]

The genomic sequencing of Monkeypox virus (MPXV) isolates has offered crucial insights into the virus's genetic variability and population biology. This review provides a concise summary of the current state of MPXV genetics and phylogenetics, with a ...
AL-Azzawi, Mustafa Kareem, Khlaif, Salam Mohammed, Zubaidi, Nabaa Abbas   +2 more
core   +1 more source

In-silico primer designing and PCR for detection of monkeypox virus (MPXV)

Journal of Infection and Public Health, 2022
Ying Wei Khoo, Shifang Li, Khim Phin Chong   +2 more
openaire   +3 more sources

MPXV Infects Human PBMCs in a Type I Interferon-Sensitive Manner

AbstractMPOX virus (MPXV), formerly known as monkeypox virus, led to a rapidly evolving pandemic starting May 2022, with over 90,000 cases reported beyond the African continent. This pandemic outbreak was driven by the MPXV variant Clade IIb. In addition, Clade I viruses circulating in the Democratic Republic of Congo (DRC) are drawing increased ...
Laure Bosquillon de Jarcy, Dylan Postmus, Jenny Jansen, Julia Melchert, Donata Hoffmann, Victor M. Corman, Christine Goffinet   +6 more
openaire   +1 more source

Asymptomatic Mpox Virus Infection in Subjects Presenting for MVA-BN Vaccine [PDF]

, 2023
Antinori A., Bettini A., Coen S., Colavita F., Girardi E., Maggi F., Matusali G., Mazzotta V., Piselli P., Vaia F.   +9 more
core   +1 more source

Monckeypox virus (MPXV)

, 2022
Vandenbergen, Liselot, Vandercam, Geoffroy, Hoornaert, Ellen, Sluijters, Alice, Yombi, Jean Cyr   +4 more
openaire   +1 more source

ISG15 Differentially Modulates Clade Ib and II MPXV Infection in MEF cells

Abstract The unprecedented human-to-human transmission of Clade IIb monkeypox virus (MPXV) during the 2022 outbreak has renewed focus on host determinants of viral fitness. Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein with broad immunomodulatory functions, yet its role in MPXV infection remains unclear.
Joseph Patrick McGrail, Irene Campaña Gómez, Antti Tuhkala, Salla Keskitalo, Markku Varjosalo, Adolfo García Sastre, Gustavo Palacios, Mari Paz Sanchez-Seco, Susana Guerra   +8 more
openaire   +1 more source

The globally prevalent MPXV strain exhibits high airborne and contact transmissibility in black-tailed prairie dogs. [PDF]

Emerg Microbes Infect
Chen Z, Zhang L, Shao M, Zhang M, Li L, Zhao Z, Shang C, Liu Z, Liu J, Guo Z.   +9 more
europepmc   +1 more source

Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion. [PDF]

Proc Natl Acad Sci U S A
Pan Z, Zhang S, Geng X, Wang N, Zhang L, Wang L, Yin C, Zhang H, Liu S, Zhang L, Fan J, Xue G, Li R, Li T, Yu Y, Yao H, Jin C, Wu N.   +17 more
europepmc   +1 more source

Evaluation of optimal pooling strategies for Mpox virus genomic surveillance using the Illumina Viral Surveillance Panel on the iSeq100 platform in outbreak settings. [PDF]

BMJ Public Health
Nguinkal JA, Melo AM, Nzoyikorera N, Jurgen M, Affara M, Gehre F.   +5 more
europepmc   +1 more source

Development of a replication-defective MPXV platform for fundamental and therapeutic research

ABSTRACTThe recent global outbreaks of mpox highlight the urgent need for both fundamental research and antiviral development. However, studying monkeypox virus (MPXV), with its large and complex genome, remains challenging due to the requirement for high-containment facilities.
Jiannan Chen, Liyuan Hu, Ning Shi, Jiaxin Tian, Yuyi Zhang, Sicheng Tian, Xinyu Cao, Zhuo Ha, Qiliang Cai, Yongxu Lu, Geoffrey L. Smith, Youhua Xie, Huijun Lu, Ping Zhang, Rong Zhang   +14 more
openaire   +1 more source