Results 11 to 20 of about 312 (110)

Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism [PDF]

Frontiers in Physiology, 2022
Melanocortin receptors (MC1R-MC5R) and their accessory proteins (MRAPs) are involved in a variety of physiological processes, including pigmentation, lipolysis, adrenal steroidogenesis, and immunology.
Xiao Zhang, Jiancheng Su, Tianjiao Huang, Xinglong Wang, Chenlei Wu, Jing Li, Juan Li, Jiannan Zhang, Yajun Wang   +8 more
doaj   +2 more sources

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis [PDF]

Frontiers in Endocrinology, 2022
The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang   +8 more
doaj   +2 more sources

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2 [PDF]

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +2 more sources

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis [PDF]

Endocrine Connections, 2021
As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang   +12 more
doaj   +2 more sources

The C-terminal domains of melanocortin-2 receptor (MC2R) accessory proteins (MRAP1) influence their localization and ACTH-induced cAMP production [PDF]

General and Comparative Endocrinology, 2012
ACTH binding to the human melanocortin-2 receptor (MC2R) requires the presence of the MC2R accessory protein1 isoforms, MRAPα or MRAPβ. This study evaluated the role of the isoform-specific C-terminal domains of MRAP with regard to their cellular localization, topology, interaction with MRAP2 and cAMP production.
Maria Josep Agulleiro, Jose Miguel Cerda-Reverter   +1 more
exaly   +4 more sources

Pharmacological properties of whale shark (Rhincodon typus) melanocortin-2 receptor and melancortin-5 receptor: Interaction with MRAP1 and MRAP2

General and Comparative Endocrinology, 2020
In the current study, the whale shark (ws; Rhincodon typus) melanocortin-2 receptor (MC2R) co-expressed with wsMRAP1 in Chinese Hamster Ovary (CHO) Cells could be stimulated in a dose dependent manner by ACTH(1-24) with an EC50 of 2.6 × 10-10 M ± 9.7 × 10-11. When the receptor was expressed alone, stimulation was only observed at [10-6 M]. A comparable
Brianne E, Hoglin, Marin, Miner, Robert M, Dores   +2 more
exaly   +3 more sources

Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. [PDF]

Animals (Basel), 2022
In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Navarro S, Crespo D, Schulz RW, Ge W, Rotllant J, Cerdá-Reverter JM, Rocha A.   +6 more
europepmc   +7 more sources

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor. [PDF]

Nat Commun
Funding: This work was supported by the Deutsche Forschungsgemeinschaft (DFG) (German Research Foundation) through SFB1423, Project-ID 421152132, subprojects C03 (to P.A., M.J.L.), B02 (to H.B.), A01/Z03 (to P.S.), A04/B01/Z03 to (A.G. B.-S.). P.A. would
Sohail I, Laurin SA, Kleinau G, Chunilal V, Morton A, Brenlla A, Kagiali ZCU, Blouin MJ, Tello JA, Beck-Sickinger AG, Lohse MJ, Scheerer P, Bouvier M, McCormick P, Annibale P, Biebermann H.   +15 more
europepmc   +7 more sources

The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. [PDF]

Sci Signal
The central melanocortin system links nutrition to energy expenditure. Melanocortin-4 receptor (MC4R) controls appetite and food intake, and its signaling is potentiated by melanocortin-2 receptor accessory protein 2 (MRAP2).
Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM.   +8 more
europepmc   +3 more sources

فلوتاسیون کانسنگ رسوبی فسفات معدن چرام [PDF]

نشریه مهندسی معدن, 2022
با توجه به کاربرد وسیع فسفات، نیاز است در رابطه با فرآوری آن، مطالعات و آزمایش های گسترده ای انجام شود. در این تحقیق از روش فلوتاسیون جهت حذف گانگ کربناته به کمک کلکتور ساخته شده G (j-mrap1) استفاده شد.
علیرضا جوادی, محمدرضا علیپور   +1 more
doaj   +1 more source