Pharmacological regulation of melanocortin-3 and -4 receptors by melanocortin-2 receptor accessory protein 1 or 2 [PDF]
, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis.
Ji, Ren-Lei Jr
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Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
International Journal of Inflammation, Volume 2013, Issue 1, 2013., 2013 The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution and anti‐inflammatory effects in preclinical models of inflammatory disease, with tissue protective effects.
Tazeen J. Ahmed +4 more
wiley +1 more source
Pharmacological characterization of fish melanocortin-4 and melanocortin-5 receptors [PDF]
, 2021 The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. The melanocortin-5 receptor (MC5R) has been implicated in the regulation of exocrine gland secretion, immune regulation, and muscle fatty ...
Liu, Ting
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Interaction of prokineticin receptors with accessory proteins [PDF]
, 2023 G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Lattanzi, Roberta, Miele, Rossella
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Molecular Peptide Grafting as a Tool to Create Novel Protein Therapeutics [PDF]
, 2023 The study of peptides (synthetic or corresponding to discrete regions of proteins) has facilitated the understanding of protein structure-activity relationships. Short peptides can also be used as powerful therapeutic agents.
Komar, Anton A.
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Estudios de estructura-actividad de la interacción entre el receptor de melanocortinas tipo 4 (MC4R) y las proteínas accesorias de los receptores de melanocortinas (MRAPs) e implicación de las melanocortinas en la regulación de los ritmos circadianos de actividad [PDF]
, 2020 [ES] El sistema de melanocortinas es un sistema hormonal crítico en la respuesta al estrés y el control del balance energético. Sus péptidos agonistas, las hormonas estimuladoras de los melanocitos (MSHs) y la hormona adrenocorticotropa (ACTH) están ...
Soletto Esteban, Lucía
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Analyzing the Effect on Ligand Sensitivity for Xenopus Tropicalis MC1R, MC3R, MC4R, and MC5R as a Result of Coexpression with Gallus Gallus MRAP1 in Chinese Hamster Ovary Cells [PDF]
, 2020 Some melanocortin receptors and the accessory protein MRAP1 have been found to interact in novel ways when co-expressed in the same cells following stimulation with either ACTH (1-24) or αMSH.
Dores, Robert, Niemann, Avery
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British Journal of Pharmacology, Volume 181, Issue 14, Page 2212-2231, July 2024.Background and Purpose Receptor activity‐modifying proteins (RAMPs) and melanocortin receptor accessory proteins (MRAPs) modulate expression and signalling of calcitonin and melanocortin GPCRs. Interactions with other GPCRs have also been reported. The cannabinoid receptors, CB1 and CB2, and two putative cannabinoid receptors, GPR18 and GPR55, exhibit ...
Nathaniel A. K. Glenn +5 more
wiley +1 more source
Agouti overexpression in a transgenic model regulates integrity, permeability and electrogenic amino acid transport in zebrafish intestine [PDF]
, 2022 Overexpression of asip1 in transgenic zebrafish disrupts dorsoventral pigment pattern in addition to increasing food intake levels and linear growth. A higher feed intake is unnecessary in transgenic fish to enable larger and heavier growth.
Angotzi, Anna Rita +7 more
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Unravelling the Melanocortin 5 Receptor signalling pathway. [PDF]
, 2008 [resumo ...
Almeida, Henrique +3 more
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