Results 21 to 30 of about 312 (110)

The Multifaceted Melanocortin Receptors. [PDF]

Endocrinology, 2022
The 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC(2), these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that ...
Laiho L, Murray JF.
europepmc   +3 more sources

hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation. [PDF]

PLoS ONE, 2015
MRAP1 but not MRAP2, is essential for melanocortin receptor 2 functional expression. Human MRAP1 splice variant (hMRAPα) and human MRAP2 (hMRAP2) also interact with the other melanocortin receptor subtypes in vitro, although the physiological ...
Emma I Kay, Rikus Botha, Johanna M Montgomery, Kathleen G Mountjoy   +3 more
doaj   +1 more source

GATA‐type transcription factor MrNsdD regulates dimorphic transition, conidiation, virulence and microsclerotium formation in the entomopathogenic fungus Metarhizium rileyi

Microbial Biotechnology, Volume 13, Issue 5, Page 1489-1501, September 2020., 2020
The significance of MrNsdD in dimorphic transition, conidium and microsclerotium formation. The MrNsdD mediated regulation of target genes involved in dimorphic transition and microsclerotium development. It provides valuable understanding the molecular mechanism of dimorphic transition and microsclerotium development.
Caiyan Xin, Jie Yang, Yingyu Mao, Wenbi Chen, Zhongkang Wang, Zhangyong Song   +5 more
wiley   +1 more source

Rising Stars in Avian Physiology: 2022 [PDF]

, 2023
We are delighted to present the inaugural Frontiers in Physiology “Rising Stars in Avian Physiology” annual series of article collections. Recognizing the future leaders in avian physiology is fundamental to safeguarding tomorrow's driving force in ...
Vicent M. Cassone, Petracci M.
core   +1 more source

Pathophysiology of melanocortin receptors and their accessory proteins. [PDF]

, 2018
The melanocortin receptors (MCRs) and their accessory proteins (MRAPs) are involved in regulation of a diverse range of endocrine pathways. Genetic variants of these components result in phenotypic variation and disease. The MC1R is expressed in skin and
A.J.L. Clark, Anderson, Asai, Balthasar, Begriche, Benjannet, Bishop, Box, Buggy, Bultman, Butler, Butler, Böhm, Chakraborty, Chaly, Chan, Chan, Chan, Chen, Chen, Chen, Cheung, Chida, Chung, Chung, Clark, Clark, Clark, Clark, Coll, Collet, Cone, Cone, Cooray, Cooray, Cooray, Cui, D'Orazio, do Carmo, Elias, Enriori, Farooqi, Feng, Flier, Friedman, Gee, Ghamari-Langroudi, Girardet, Gonzalez-Rey, Gorrigan, Greenfield, Huszar, Jarrett, Kievit, Kim, L.F. Chan, Landi, Lee, Lee, Lembertas, Lim, Lovett, Lowry, Lu, Manceau, Markison, Marks, Marsh, Martinelli, Metherell, Metherell, Miller, Mirshahi, Morgan, Morgan, Morgan, Mountjoy, Mountjoy, Ni, Nimura, Novoselova, O'Rahilly, Ogawa, Ollmann, Padilla, Palmer, Pasquali, Pelleymounter, Raadsheer, Rached, Raimondi, Robbins, Robles-Espinoza, Rodrigues, Roselli-Rehfuss, Rouault, Roy, Schauer, Scott, Sebag, Sebag, Shen, Shenker, Simamura, Smith, Smith, Sohn, Srisai, Swords, T.V. Novoselova, Tao, Turan, Ulrich-Lai, Vaisse, Valverde, Vinson, Webb, Webb, Weber, Williams, Xu, Xu, Yang, Yeo, Young, Zhang, Zhang   +126 more
core   +2 more sources

Promiscuity among the MRAPs. [PDF]

, 2017
The melanocortin 2 receptor accessory protein (MRAP) was originally discovered to be an essential co-receptor for the ACTH receptor/melanocortin 2 receptor, and it physically interacts with this receptor and is required for receptor trafficking and ...
Chan, LF, Clark, AJL
core   +1 more source

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways [PDF]

Hum Mol Genet
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor expressed at hypothalamic neurons that has an important role in appetite suppression and food intake.
Wyatt RA, Jamaluddin A, Mistry V, Quinn C, Gorvin CM.   +4 more
europepmc   +4 more sources

G protein-coupled receptors: what a difference a 'partner' makes [PDF]

, 2014
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately,
Abu-Helo, Aiyar, Ardura, Attramadal, Babu, Baker, Bartlett, Behrens, Benovic, Benoît Roux, Bermak, Beuming, Björk, Bofill-Cardona, Bomberger, Bornert, Bouschet, Bradbury, Brady, Bretscher, Buck, Buhlmann, Bukau, Bécamel, Cabrera-Vera, Cai, Cao, Caron, Chabre, Chakraborty, Chan, Chen, Cheung, Christopoulos, Christopoulos, Chung, Claing, Clark, Clark, Clark, Colley, Cone, Cook, Cottrell, Cowen, Craig, Dackor, Dackor, Dores, Dunn, Dupré, Dupré, Dwyer, Décaillot, Egea, Ellgaard, Ellis, Evans, Evron, Fam, Ferguson, Ferreira, Fiedler, Fluhmann, Force, Fraser, Fredriksson, Gage, Gardner, Gerke, Gimelbrant, Girard, Goadsby, Graeme Cottrell, Gullapalli, Hamm, Han, Hay, Heydorn, Hilairet, Hilairet, Humrich, Jones, Kadmiel, Kadmiel, Kakiuchi, Kang, Kappeler, Kelley, Kennedy, Kjeldgaard, Kristiansen, Kuang, Kurten, Laburthe, Leclerc, Lee-Kwon, Levitt, Li, Lin, Lohse, Lu, Lucas, Luebke, Lukov, Lutz-Bucher, Ma, Mahon, Mahon, Mahon, Mai, Mancias, Marchese, Marenholz, McClintock, McClintock, McLatchie, Metherell, Miret, Montecucchi, Morello, Mountjoy, Muff, Murphy, Murrell, Málaga-Diéguez, Naghashpour, Nakajima, Nickols, Nikitenko, Nisar, Nishimura, Njuki, Noon, Noorwez, Oh, Oh, Okuse, Oliver, Overgaard, O’Neill, Paquet, Park, Parmentier, Petaja-Repo, Pfeffer, Pittman, Ponting, Prado, Premont, Pálfy, Ritter, Rivero-Müller, Rochdi, Roh, Romero, Rosenblatt, Saito, Sapolsky, Sarkar, Schmidt, Sebag, Sebag, Shenoy, Shieh, Simonin, Sorensen, Spehr, Stamnes, Strasser, Svenningsson, Svenningsson, Tan, Tsujikawa, Turner, Voeltz, Vos, Walther, Wang, Wang, Wang, Wang, Wang, Warner-Schmidt, Warner-Schmidt, Webb, Whistler, Wootten, Yamniuk, Yang, Zobiack   +190 more
core   +4 more sources

Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia. [PDF]

PLoS Biol
The G protein-coupled receptor (GPCR) melanocortin receptor 4 (MC4R) is an essential regulator of body weight homeostasis. MC4R is unusual among GPCRs in that its activity is regulated by 2 opposing physiological ligands, the agonist ⍺-MSH and the ...
Ojeda-Naharros I, Das T, Castro RA, Bazan JF, Vaisse C, Nachury MV.   +5 more
europepmc   +3 more sources

Melanocortin receptor accessory proteins in adrenal disease and obesity. [PDF]

, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
Adrian J. Clark, Agulleiro, Asai, Balthasar, Beaumont, Beaumont, Begriche, Begriche, Berglund, Bouw, Breit, Catania, Chai, Chambers, Chan, Chen, Chen, Chida, Chung, Clark, Clark, Cone, Cooray, David S. Jackson, Dores, Elias, Farooqi, Gardiner, Getting, Gorrigan, Griffon, He, Hinkle, Hofland, Hu, Hughes, Huszar, Kay, Kay, Kiefer, Kim, Lee, Leoni, Li F. Chan, Lim, Liu, Loos, Lu, MacNeil, Mencarelli, Metherell, Mo, Moller, Montero-Melendez, Nijenhuis, Noon, O'Shaughnessy, Ollmann, Panaro, Park, Pritchard, Rodrigues, Roy, Roy, Rumie, Sebag, Sebag, Sebag, Sebag, Shutter, Shwetha Ramachandrappa, Smith, Sohn, Star, Sutton, Sutton, Sutton, Swope, Tontonoz, Vage, Vaisse, van der Kraan, van der Ploeg, Vinson, Webb, Xu, Yang, Yeo, Zhong   +88 more
core   +2 more sources