Results 31 to 40 of about 19,153 (149)

Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

Cell Reports Medicine, 2020
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as ...
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto   +32 more
doaj   +1 more source

Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model

SAGE Open Medicine, 2017
Introduction: Despite the widespread use of the mouse transverse aortic constriction heart failure model, there are no reports on the characterization of the standard-of-care agent carvedilol in this model. Methods: Left ventricular pressure overload was
Caryn Hampton, Raymond Rosa, Daphne Szeto, Gail Forrest, Barry Campbell, Richard Kennan, Shubing Wang, Chin-Hu Huang, Loise Gichuru, Xiaoli Ping, Xiaolan Shen, Kersten Small, Jeffrey Madwed, Joseph J Lynch   +13 more
doaj   +1 more source

Spine inflammatory changes in patients with ankylosing spondylitis assessed by magnetic resonance image

Научно-практическая ревматология, 2008
Objective. To develop the optimal mode of spine evaluation with magnetic resonance image (MRl) in pts with ankylosing spondylitis (AS) and to study relationship between MR!
A G Bochkova, A. V. Levshakova, N. I. Bunchuk   +2 more
doaj   +1 more source

Cross reactivity within pneumococcal serogroups 6 and 15 following adult vaccination with pneumococcal conjugate vaccine V116

Communications Medicine
Background Pneumococcal conjugate vaccines (PCVs) are designed to induce serotype-specific antibodies; however, antibodies raised against pneumococcal polysaccharides in the vaccine can also cross-react to other serotypes based on structural similarities.
Jianing Li, Heather L. Platt, Wenyu Hu, Weifeng Xu, Timothy J. Chapman, Katrina M. Nolan, Jonathan Hartzel, Ulrike K. Buchwald   +7 more
doaj   +1 more source

Hard Turning Performance Investigation of AISI D2 Steel under a Dual Nozzle MQL Environment

Lubricants, 2023
In recent years, hard turning has emerged as a burgeoning cutting technology for producing high-quality finishing of cylindrical-shaped hardened steel for a variety of industrial applications.
Rajashree Mallick, Ramanuj Kumar, Amlana Panda, Ashok Kumar Sahoo   +3 more
doaj   +1 more source

Single cell spatial profiling of FFPE splenic tissue from a humanized mouse model of HIV infection

Biomarker Research
Background Latency remains a major obstacle to finding a cure for HIV despite the availability of antiretroviral therapy. Due to virus dormancy, limited biomarkers are available to identify latent HIV-infected cells.
Guoxin Wu, Samuel H. Keller, Luca Sardo, Brian Magliaro, Paul Zuck, Carl J. Balibar, Claire Williams, Liuliu Pan, Mark Gregory, Kathy Ton, Jill Maxwell, Carol Cheney, Tom Rush, Bonnie J. Howell   +13 more
doaj   +1 more source

Development of an Ultrasensitive ELISA Assay for Evaluating HIV-1 Envelope Glycoprotein as a Marker for Targeted Activator of Cell Kill

Viruses
The HIV-1 envelope glycoprotein gp120 is prominently exposed on the surface of both HIV-1 virions and infected host cells, serving as a key marker of infection.
Guoxin Wu, Luca Sardo, Yuan Li, Steven D. Heron, BaoJen Shyong, Matthew Mazur, Daniel M. Gorman, Carl J. Balibar, Brian C. Magliaro, Craig Leach, Thomas Rush, Bonnie J. Howell   +11 more
doaj   +1 more source

Practical experiences with a syrup feeding study design based on a new MRL guideline SANTE11956/2016 rev.9 (2018)

Julius-Kühn-Archiv, 2020
A new study design, according to the guideline SANTE11956/2016 rev:9 (2018), was established to determine the maximum residue level (MRL) of plant protection products in honey.
Cohen, Yotam, Berger, Christian, Gonsior, Gundula, Knäbe, Silvio   +3 more
doaj   +1 more source

WASPAS Based Multi Response Optimization in Hard Turning of AISI 52100 Steel under ZnO Nanofluid Assisted Dual Nozzle Pulse-MQL Environment

Applied Sciences, 2023
Hard turning is an emerging machining technology that evolved as a substitute for grinding in the production of precision parts from hardened steel. It offers advantages such as reduced cycle times, lower costs, and environmental benefits over grinding ...
Saswat Khatai, Ramanuj Kumar, Amlana Panda, Ashok Kumar Sahoo   +3 more
doaj   +1 more source

Biostructural, biochemical and biophysical studies of mutant IDH1

Nature Communications
We report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform.
Mark A. McCoy, Jun Lu, F. Richard Miller, Stephen M. Soisson, Michael H. Lam, Christian Fischer   +5 more
doaj   +1 more source