Results 31 to 40 of about 88,502 (304)
mAbs, 2022 Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development.
David Prihoda +6 more
doaj +1 more source
Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]
, 2015 Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M. +4 more
core +1 more source
Inhibition of EZH2 ameliorates lupus-like disease in MRL/lpr mice
bioRxiv, 2018 Objectives We previously revealed a role for EZH2 in inducing pro-inflammatory epigenetic changes in lupus CD4+ T cells. In this study, we sought to determine if inhibiting EZH2 ameliorates lupus-like disease in MRL/lpr mice.
Dallas M. Rohraff +5 more
semanticscholar +1 more source
Foods, 2020 Although the impact of oxidation on human health has been of growing interest, the oxidation of proteins, major component of meat, has received little attention.
Johana Márquez-Lázaro +2 more
doaj +1 more source
The FASEB Journal, 2019 Although the mouse strain Murphy Roths Large (MRL/MpJ) possesses high regenerative potential, the mechanism of tissue regeneration, including skeletal muscle, in MRL/MpJ mice after injury is still unclear.
K. Sinha +8 more
semanticscholar +1 more source
Gene transfer of RANTES elicits autoimmune renal injury in MRL-Faslpr mice [PDF]
, 1998 Infiltrating macrophages and T cells are instrumental in autoimmune kidney destruction of MRL-Faslpr mice. We report that the β-chemokine RANTES, a chemoattractant for macrophages and T cells, is up-regulated in the MRL-Faslpr kidney prior to injury, but
Barbee, Susannah D. +3 more
core +1 more source
Sequential study of vasculitis in MRL mice [PDF]
Laboratory Animals, 1987 The frequency, age of onset and organ distribution of spontaneously occurring vasculitis was examined in a sequential study with 170 MRL mice of both substrains. Necrotizing vasculitis was seen in 55·8% of MRL/Mp-lpr/lpr mice studied, beginning at the age of 3 months. The kidney and urinary bladder were most frequently involved.
G. Trautwein, M. Hewicker
openaire +3 more sources
The new complement inhibitor CRIg/FH ameliorates lupus nephritis in lupus-prone MRL/lpr mice
BMC Nephrology, 2019 BackgroundsThe aberrant activation of complement system is critically involved in lupus nephropathy. Recent study showed complement C3 inhibitor was effective in the treatment of lupus nephropathy.
Yu-jia Shi +7 more
semanticscholar +1 more source
Jurnal Pendidikan IPA Indonesia, 2018 This study was conducted to determine the effectiveness of multiple representation-based learning (MRL) model compared to discovery learning (DL) model and problem based learning (PBL) model in terms of students’ initial abilities.
S. Sunyono, A. Meristin
semanticscholar +1 more source
Human Vaccines & Immunotherapeutics, 2017 T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation ...
Aimin Tang +8 more
doaj +1 more source