Results 41 to 50 of about 602,475 (301)

Signaling control of SOS1 mRNA stability [PDF]

Plant Signaling & Behavior, 2008
Regulation of mRNA decay rates appears to be an important control point in determining the abundance of gene transcripts. Rapid change in decay rates of mRNAs could provide prompt responses of the plants to environmental fluctuations. SOS1 is a plasma-membrane Na(+)/H(+) antiporter crucial for salt tolerance in Arabidopsis.
Jiafu, Jiang, Huazhong, Shi
openaire   +2 more sources

Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]

, 2012
Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M, Fish, Lisa, Goodarzi, Hani, Greco, Todd M, Najafabadi, Hamed S, Oikonomou, Panos, Salavati, Reza, Tavazoie, Saeed   +7 more
core   +2 more sources

mRNA Stability Assay Using Transcription Inhibition by Actinomycin D in Mouse Pluripotent Stem Cells

Bio-Protocol, 2018
Gene expression is regulated through multiple steps at both transcriptional and post-transcriptional levels. The net abundance of mature mRNA species in cells is determined by the balance between transcription and degradation.
Madara Ratnadiwakara, Minna-Liisa Änkö
doaj   +1 more source

The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization

Non-Coding RNA, 2021
mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay.
Maialen Sebastian-delaCruz, Itziar Gonzalez-Moro, Ane Olazagoitia-Garmendia, Ainara Castellanos-Rubio, Izortze Santin   +4 more
doaj   +1 more source

RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA [PDF]

, 2016
Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation.
BOZZONI, Irene, De Vito, Francesca, DEL VECCHIO, GIORGIA, Mannironi, Cecilia, PRESUTTI, Carlo, Risi, Adele, Saunders, Sita J   +6 more
core   +1 more source

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Nature Communications, 2022
The authors develop an RNA sequencing-based platform, PERSIST-seq, to simultaneously delineate in-cell mRNA stability, ribosome load, and in-solution stability of a diverse mRNA library to derive design principles for improved mRNA therapeutics.
Kathrin Leppek, Gun Woo Byeon, Wipapat Kladwang, Hannah K. Wayment-Steele, Craig H. Kerr, Adele F. Xu, Do Soon Kim, Ved V. Topkar, Christian Choe, Daphna Rothschild, Gerald C. Tiu, Roger Wellington-Oguri, Kotaro Fujii, Eesha Sharma, Andrew M. Watkins, John J. Nicol, Jonathan Romano, Bojan Tunguz, Fernando Diaz, Hui Cai, Pengbo Guo, Jiewei Wu, Fanyu Meng, Shuai Shi, Eterna Participants, Philip R. Dormitzer, Alicia Solórzano, Maria Barna, Rhiju Das   +28 more
doaj   +1 more source

Matrin 3 Binds and Stabilizes mRNA

PLoS ONE, 2011
Matrin 3 (MATR3) is a highly conserved, inner nuclear matrix protein with two zinc finger domains and two RNA recognition motifs (RRM), whose function is largely unknown. Recently we found MATR3 to be phosphorylated by the protein kinase ATM, which activates the cellular response to double strand breaks in the DNA. Here, we show that MATR3 interacts in
Salton, M., Elkon, R., Borodina, T., Davydov, A., Yaspo, M., Halperin, E., Shiloh, Y.   +6 more
openaire   +5 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2 [PDF]

, 2008
The role(s) of the novel stargazin-like {gamma}-subunit proteins remain controversial. We have shown previously that the neuron-specific {gamma}7 suppresses the expression of certain calcium channels, particularly CaV2.2, and is therefore unlikely to ...
Bolsover, Steven, Butcher, Adrian J., Cox, David J., Davies, Anthony, Dolphin, Annette C., Ferron, Laurent, Leroy, Jerôme, Moss, Fraser J., Page, Karen M., Pratt, Wendy S., Sellaturay, Priya, Waithe, Dominic   +11 more
core   +1 more source