Results 161 to 170 of about 405,975 (264)

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation. [PDF]

Adv Sci (Weinh)
Li S, Zhao X, Song T, Chen Q, Wu Y, Zhang Y, Chen J, Wu Y, Li B, Zhang X, Dai Z, Xu L, Xie Y, Cheng AS, Guo J, Kuang M, Lin S, Peng Z, Peng S, Zeng X.   +19 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

RNA binding protein YWHAZ mediates specific mRNA translation and regulates cell proliferation and apoptosis in diabetic foot ulcer. [PDF]

Front Med (Lausanne)
Zha T, Yao J, Wang H, Cao Q, Zhang J, Chen Z, Wang J.   +6 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2. [PDF]

Nat Commun
Wilson JCJ, Zhu J, Vinciauskaite V, Lloyd EG, Lam S, Hart A, Goh CG, Bou-Dagher F, Razumkov H, Kobel L, Kontarakis Z, Fielden J, Schlapansky MF, Loizou JI, Villunger A, Corn JE, Biffi G, Masson GR, Marciniak SJ, Bader AS, Jackson SP.   +20 more
europepmc   +2 more sources

Deep generative optimization of mRNA codon sequences for enhanced mRNA translation and therapeutic efficacy. [PDF]

Nat Commun
Li Y, Wang F, Yang J, Han Z, Chen L, Jiang W, Zhou H, Li T, Tang Z, Deng J, He X, Zha G, Hu Z, Hu Y, Wu L, Zhan C, Sun C, He Y, Xie Z.   +18 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

CDC123 is an ATPase that modulates mRNA translation and the integrated stress response by regulating eIF2 complex assembly. [PDF]

J Biol Chem
Erb AL, Young-Baird SK.
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Protocol for monitoring mRNA translation and degradation in human cell-free lysates. [PDF]

STAR Protoc
Schwaller N, Karousis ED.
europepmc   +1 more source