Results 11 to 20 of about 1,500,723 (302)

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

New England Journal of Medicine, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic.
Fernando P Polack, Stephen J Thomas, Judith Absalon   +2 more
exaly   +2 more sources

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

ACS Nano, 2021
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively ...
Rumiana Koynova, Qiongqiong Zhou
exaly   +2 more sources

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Nature, 2020
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic.
Kizzmekia S Corbett, Darin K Edwards, Sarah R Leist   +2 more
exaly   +2 more sources

PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge

mBio
Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causes severe diarrhea in neonatal piglets, which is associated with a high mortality rate.
Yongxiang Zhao, Baochao Fan, Xu Song, Jie Gao, Rongli Guo, Cheng Yi, Zhaoming He, Hongpeng Hu, Jianhao Jiang, Lixiang Zhao, Tianyi Zhong, Bin Li   +11 more
doaj   +2 more sources

Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine [PDF]

The Journal of Clinical Investigation
Although virus-like particle (VLP) vaccines were shown to be effective against several viruses, their advantage over vaccines that include envelope protein only is not completely clear, particularly for mRNA-encoded VLPs.
Chandru Subramani, Michelle Meyer, Matthew A. Hyde, Margaret E. Comeaux, Haiping Hao, James E. Crowe Jr., Vsevolod L. Popov, Harshwardhan Thaker, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +10 more
doaj   +2 more sources

mRNA vaccine for cancer immunotherapy [PDF]

Molecular Cancer, 2021
mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune
Lei Miao, Yu Zhang, Leaf Huang
semanticscholar   +4 more sources

Immunogenicity and efficacy of an mRNA vaccine expressing a virus-like particle spike antigen against SARS-CoV-2 [PDF]

npj Vaccines
The COVID-19 pandemic spurred mRNA vaccine innovation, but new SARS-CoV-2 variants highlight the need for vaccines with improved potency and durability.
Jason P. Laliberte, Yingyun Cai, Tara Kenny, Yi Zhang, Kuishu Ren, Kim Rosenthal, Daniel Flores, Richard Roque, Oliver Acton, Vanessa Cadevilla Peano, Noel Janney, Vinita Puri, Sarah Siddiqui, Angela Pack, Giune Padilla, Seme Diallo, Hibret Adissu, Rakesh Choudhary, Hawley Pruitt, Yi-Han Cheng, George Thom, Michael Newton, Cheyne Kurokawa, Johnathan Guest, Phillip Swanson, Yueh-Ming Loo, Joseph R. Francica, Wade Blair, Mark Esser   +28 more
doaj   +2 more sources

mRNA vaccine designs for optimal adjuvanticity and delivery

RNA Biology
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the co-delivery of antigen mRNA and adjuvants in a unified, all-in-one formulation.
Yuki Mochida, Satoshi Uchida
doaj   +2 more sources

Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus

Nature Communications
mRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can be produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian influenza viruses from H5 clade 2.3.
Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H. Y. Fan, Anthony T. Phan, Christopher A. Hunter, Richard J. Webby, Drew Weissman, Scott E. Hensley   +16 more
doaj   +2 more sources

Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site

Nature Communications
mRNA vaccines against SARS-CoV-2 have revolutionized vaccine development, but their immunological mechanisms are not fully understood. Here, we investigate injection site responses of mRNA vaccines by generating a comprehensive single-cell transcriptome ...
Seongryong Kim, Ji Hyang Jeon, Myeonghwan Kim, Yeji Lee, Yun-Ho Hwang, Myungsun Park, C. Han Li, Taeyoung Lee, Jung-Ah Lee, You-Me Kim, Dokeun Kim, Hyukjin Lee, You-Jin Kim, V. Narry Kim, Jong-Eun Park, Jinah Yeo   +15 more
doaj   +2 more sources