Results 1 to 10 of about 4,597 (221)

Macrophage Polarization during MRONJ Development in Mice [PDF]

Journal of Dental Research
Macrophages are important regulators of bone remodeling, and M1 polarization is observed in the setting of medication-related osteonecrosis of the jaws (MRONJ). Here, we characterize the phenotype of macrophages during early stages of MRONJ development in zoledronate (ZA)–treated mice with periodontal disease and explore the role of rosiglitazone, a ...
Akrivoula Soundia, Naseim Elzakra, Danny Hadaya, Ioannis Gkouveris, Olga Bezouglaia, Sarah Dry, Tara Aghaloo, Sotirios Tetradis   +7 more
semanticscholar   +4 more sources

ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium

Oral
On 24 February 2024, Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygienists, and other professionals met (live or online) to discuss controversial issues about medication-related osteonecrosis of the ...
Vittorio Fusco, Martina Coppini, Gaetano La Mantia, Paolo G. Arduino, Fortunato Buttacavoli, Alessio Gambino, Francesco M. Erovigni, Alberto Bedogni, Giuseppina Campisi   +8 more
doaj   +3 more sources

Clinical and Radiological Evaluation of Oral and Maxillofacial Status in Patients Undergoing Antiresorptive Therapy and Its Relationship with MRONJ [PDF]

Biomedicines
Background/Objectives: Patients undergoing antiresorptive therapy were evaluated, focusing on clinical and radiological features and their relationship with medication-related osteonecrosis of the jaw (MRONJ).
Marcela Wiltgen Jeffman, Valesca Sander Koth, Fernanda Gonçalves Salum, Maria Ivete Rockenbach, Aline Cantarelli Morosolli, Karen Cherubini   +5 more
doaj   +2 more sources

Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) [PDF]

BMC Oral Health
This study aims to evaluate the clinical outcome of biofluorescent imaging system (BIS) guided MRONJ surgery through analyzing 3D volumetric changes in CBCT data of bone structure.
Sooshin Hwang, Hyouk Keun Jee, Yesel Kim, Hong-Cheol Yoon, Pil‐Young Yun, Jeong‐Kui Ku   +5 more
openalex   +2 more sources

MRONJ and VIT D insufficiency

Journal of Craniomaxillofacial Research, 2021
Background: Medication related osteonecrosis of the jaw (MRONJ) is a chronic condition of the oral cavity resulting in mucosal ulceration and exposure of underlying necrotic bone, and the ensuing secondary complications.
Gholamreza Shirani, Arghavan Tonkaboni, Mina Mazani, Babak Mirzashahi, Abel Garcia Garcia, Mohammad Javad Kharazifard   +5 more
doaj   +2 more sources

How does medication-related osteonecrosis of the jaw (MRONJ) influence the health-related quality of life after surgery?

BMC Oral Health
Background Medication-Related Osteonecrosis of the Jaw (MRONJ), an established side effect of antiresorptive and antiangiogenic medication, could sometimes require surgical intervention, such as decortication. The objectives of this retrospective patient
Oliver Bissinger, Josefa Greiser, Elisabeth Maier, Philipp Ehrmann, Tamara Kakoschke, Klaus-Dietrich Wolff, Carolin Götz   +6 more
doaj   +2 more sources

The Role of Cone Beam Computed Tomography (CBCT) in the Diagnosis and Clinical Management of Medication-Related Osteonecrosis of the Jaw (MRONJ)

Diagnostics
Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive and antiangiogenic medications that are frequently used in treating osteoporosis and cancers.
Yui Yin Ko, Wei-Fa Yang, Yiu Yan Leung
doaj   +2 more sources

Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate

Drug Design, Development and Therapy
Siqi Zhu,1– 3,* Yajun Cui,2,3,* Weidong Zhang,2,3 Yu Ji,2,3 Lingshuang Li,2,3 Shenglei Luo,4 Jing Cui,5,6 Minqi Li2,3 1School of Stomatology, Jinzhou Medical University, Jinzhou, People’s Republic of China; 2Department of Bone Metabolism, School ...
Zhu S, Cui Y, Zhang W, Ji Y, Li L, Luo S, Cui J, Li M   +7 more
doaj   +2 more sources

Potential role of comprehensive dental care in preventing medication related osteonecrosis of the jaw (MRONJ): a single centre study

BMC Oral Health
Objective Medication-related osteonecrosis of the jaw bones (MRONJ) is a well-known complication of antiresorptive and antiangiogenic drugs. Since the first report, more occurrences of MRONJ have been described worldwide.
Kamila Alblazi, Syed Nabil, Nor Rafeah Tumian, Siti Salmiah Mohd Yunus, Roszalina Ramli   +4 more
doaj   +2 more sources

Endodontic treatment and management of patients under antiresorptive treatment: a scoping review on MRONJ risk. [PDF]

Clin Oral Investig
To summarize the current scientific evidence on the implications of root canal treatment (RCT) in patients receiving antiresorptive therapy and to outline best practices for managing such cases to prevent MRONJ.
Zavalloni G, Spinelli A, Coppini M, Mauceri R, Campisi G, Lenzi J, Gandolfi MG, Prati C, Zamparini F.   +8 more
europepmc   +2 more sources