Results 21 to 30 of about 2,084 (136)

Medication-Related Osteonecrosis of the Jaw Spontaneously Occurred in a Patient with Chronic Myelogenous Leukemia Only by Imatinib: A Report of a Rare Case

Case Reports in Dentistry, 2021
The prevalence of medication-related osteonecrosis of the jaw (MRONJ) associated with molecular-targeted therapies such as bevacizumab and sunitinib has been constantly increasing in recent years.
Makiko Okubo-Sato, Kenji Yamagata, Satoshi Fukuzawa, Kazuhiro Terada, Fumihiko Uchida, Naomi Ishibashi-Kanno, Hiroki Bukawa   +6 more
doaj   +1 more source

A retrospective study on odontogenic and non-odontogenic medication-related osteonecrosis of the jaw: Potential differences in clinical features and treatment outcomes

Journal of Dental Sciences
Background/purpose: Local infections, such as periodontal disease or apical lesions, and invasive dental procedures, such as tooth extraction, are thought to trigger medication-related osteonecrosis of the jaw (MRONJ) development.
Mizuho Ohnuma, Mitsunobu Otsuru, Keisuke Omori, Kota Morishita, Saki Hayashida, Sakiko Soutome, Kei-ichiro Miura, Masahiro Umeda, Tomohiro Yamada   +8 more
doaj   +1 more source

Risk factors for the development of medication-related osteonecrosis of the jaw and effects of tooth extraction with local infection

Journal of Dental Sciences
Background/purpose: Tooth extraction has been avoided in patients receiving antiresorptive agent (ARA) therapy. This study aimed to investigate dental findings associated with medication-related osteonecrosis of the jaw (MRONJ) development in patients ...
Norio Nakamura, Mitsunobu Otsuru, Taro Miyoshi, Koki Suyama, Keisuke Omori, Kota Morishita, Sakiko Soutome, Satoshi Rokutanda, Kei-ichiro Miura, Masahiro Umeda   +9 more
doaj   +1 more source

Medication-related osteonecrosis of the jaw without osteolysis on computed tomography: a retrospective and observational study

Scientific Reports, 2023
Medication-related osteonecrosis of the jaw (MRONJ) is a refractory osteonecrosis caused by antiresorptive agents such as bisphosphonate and denosumab (DMB).
Yuki Sakamoto, Shunsuke Sawada, Yuka Kojima   +2 more
doaj   +1 more source

Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso)

Archives of Endocrinology and Metabolism, 2020
Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs.
Miguel Madeira, André Caroli Rocha, Carolina Aguiar Moreira, Águida Maria Menezes Aguiar, Sergio Setsuo Maeda, Abel Silveira Cardoso, Charlles Heldan de Moura Castro, Catarina Brasil D'Alva, Barbara Campolina Carvalho Silva, Bruno Ferraz-de-Souza, Marise Lazaretti-Castro, Francisco Bandeira, Sandra R. Torres   +12 more
doaj   +1 more source

Estradiol replacement attenuates alendronate‐associated adverse effects on alveolar bone repair in ovariectomized rats

Journal of Periodontology, EarlyView.
Abstract Background Sodium alendronate (ALN) is widely used to treat postmenopausal osteoporosis, but both estrogen deficiency and antiresorptive therapy may impair alveolar bone repair after tooth extraction. A clinically relevant but insufficiently explored scenario involves estrogen‐deficient individuals receiving hormone replacement therapy (HRT ...
Pedro H. C. Isaias, Paulo G. B. Silva, Isabelly V. do Nascimento, Raul A. D. A. da Silva, Thayla M. do C. Sousa, Ana J. A. de de Vasconcelos, José V. M. Lemos, Fabrício B. Sousa, Ana P. N. N. Alves, Mário R. L. Mota   +9 more
wiley   +1 more source

The Effects of Simulation‐Based Interprofessional Education on Oncology Oral Care Competencies Among Dental and Dental Hygiene Students

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction This study applied simulation‐based interprofessional education (IPE) principles to develop an oncology oral care scenario, with the aim of evaluating the intervention's effects on the IPE core competencies of dental and dental hygiene students before their clinical internships. Materials and Methods Twenty‐eight fifth‐year dental
Shin‐Ru Liao, Pei‐Chen Lin, Ai‐Hua Chang, Kun‐Tsung Lee, Peih‐Ying Lu, Hsiao‐Ling Huang, Ju‐Hui Wu   +6 more
wiley   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Chronic Periodontal Infection and Not Iatrogenic Interference Is the Trigger of Medication-Related Osteonecrosis of the Jaw: Insights from a Large Animal Study (PerioBRONJ Pig Model)

Medicina, 2023
Background and Objectives: Antiresorptive drugs are widely used in osteology and oncology. An important adverse effect of these drugs is medication-induced osteonecrosis of the jaw (MRONJ).
Matthias Troeltzsch, Stephan Zeiter, Daniel Arens, Dirk Nehrbass, Florian A. Probst, Paris Liokatis, Michael Ehrenfeld, Sven Otto   +7 more
doaj   +1 more source

Grading in Gerodontology: A Framework

Gerodontology, EarlyView.
ABSTRACT Introduction Understanding and anticipating oral health deterioration in older adults requires more than describing their current oral and general health. Risk factors arising from oral, systemic and social domains strongly influence disease progression, care complexity and the ability to maintain function over time.
Falk Schwendicke, Gerry McKenna, Frauke Müller, Azize Bell, Najla Chebib, Cristiane Da Mata, Helena Dujic, Jennifer Gallagher, Barbara Janssens, Danielle M. Layton, Manabu Kanazawa, Anastassia Kossioni, Sabrina Maniewicz, Koichiro Matsuo, Pedro Molinero Mourelle, Annika Neri, Takahiro Ono, Sungkrit Pojmonpiti, Foteini Spyraki, Kittipit Srisanoi, Saif S. Syed, Sayaka Tada, Georgios Tsakos, Terry R. Walton, W. Murray Thomson, Jean‐Philippe Haesler, Sophie Dartevelle, Murali Srinivasan   +27 more
wiley   +1 more source