Results 161 to 170 of about 40,013 (196)

MSH2 splice site mutation and endometrial cancer

International Journal of Gynecological Cancer, 2006
Hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited syndrome of cancer susceptibility caused by germ line mutations of genes participating in mismatch repair (MMR). Carriers of MMR gene mutations have an increased risk of colorectal cancers and cancer of other organs.
Bianchi, F., Rosati, S., Belvederesi, L., Loretelli, C., Catalani, R., Mandolesi, A., Bracci, R., Bearzi, I., Porfiri, E., Cellerino, R.   +9 more
openaire   +2 more sources

MSH2 and MLH1 immunodetection and the prognosis of colon cancer

International Journal of Oncology, 2001
MSH2 and MLH1 are proteins involved in DNA reparation. They are mutated in some forms of colon cancer, i.e. hereditary non-polyposis carcinomas and a subset of sporadic carcinomas. We have studied the expression of MSH2 and MLH1 in a retrospective series of 225 colorectal carcinomas by immunohistochemistry.
J, Perrin, J, Gouvernet, D, Parriaux, T, Noguchi, M H, Giovannini, M, Giovannini, J R, Delpero, D, Birnbaum, G, Monges   +8 more
openaire   +2 more sources

Expressional analysis of MLH1 and MSH2 in breast cancer

Current Problems in Cancer, 2019
Mismatch repair proteins are ubiquitous keys in diverse cellular functions and protects the genome by correcting mismatch as post replication error correction machinery. Mismatch repair deficiency was associated with tumor development and progression therefore, current study was aimed to investigate MLH1 and MSH2 expression in breast cancer and ...
Saima Shakil Malik, Nosheen Masood, Muhammad Asif, Parvez Ahmed, Zafar Ullah Shah, Jahangir Sarwar Khan   +5 more
openaire   +2 more sources

Breast cancer in an MSH2 gene mutation carrier

Human Pathology, 2005
A 49-year-old woman presented with breast cancer. She is a member of a family with the hereditary nonpolyposis colorectal cancer syndrome for which a 2-base pair deletion in exon 11 of the mismatch repair gene MSH2 (c1705_1706 delGA) had been identified. Breast cancer is rare in the hereditary nonpolyposis colorectal cancer syndrome.
Westenend, PJ, Schutte, R, Hoogmans, MMCP (Monique), Wagner, Anja, Dinjens, Winand   +4 more
openaire   +2 more sources

Mechanisms of pathogenicity in humanMSH2missense mutants

Human Mutation, 2008
The human mismatch repair (MMR) gene MSH2 is the second most frequently mutated hereditary nonpolyposis colorectal cancer (HNPCC) susceptibility locus. Given that missense mutations account for 17% of all identified alterations in this gene, the study of their pathogenicity is of increasing importance.
Ollila, S, Dermadi Bebek, D, Jiricny, J, Nyström, M   +3 more
openaire   +2 more sources

Is MSH2 a breast cancer susceptibility gene?

Familial Cancer, 2007
Mutations in the DNA mismatch repair gene MSH2 lead to increased replication error and microsatellite instability and account for a substantial proportion of hereditary non-polyposis colorectal cancer (Lynch syndrome). A recent international collaborative genome-wide linkage scan (GWS) for breast cancer susceptibility loci found some evidence for there
Ee Ming, Wong, Andrea A, Tesoriero, Gulietta M, Pupo, Margaret R E, McCredie, Graham G, Giles, John L, Hopper, Graham J, Mann, David E, Goldgar, Melissa C, Southey   +8 more
openaire   +2 more sources

MSH2

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair

DNA Repair, 2022
Felipe A Calil, Richard D Kolodner, Christopher D Putnam   +2 more
exaly  

The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

Oncogene, 2003
Annapaola Franchitto, Pietro Pichierri, Marco Crescenzi   +2 more
exaly  

Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis

British Journal of Cancer, 2000
S D Bouffler, R Cox, Riccardo Fodde
exaly