Results 11 to 20 of about 42,200 (256)
Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome [PDF]
Frontiers in Oncology, 2021 BackgroundA large proportion of patients with Lynch syndrome (LS) have MSH2 abnormalities, but genotype-phenotype studies of MSH2 mutations in LS are still lacking.
Lin Dong +7 more
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Erratum: The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent [PDF]
Journal of Molecular Biology, 2009 DNA mismatch repair (MMR) is a highly conserved mutation avoidance mechanism that corrects DNA polymerase misincorporation errors. In initial steps in MMR, Msh2-Msh6 binds mispairs and small insertion/deletion loops, and Msh2-Msh3 binds larger insertion/deletion loops.
Barbara Owen +2 more
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Hesperetin effect on MLH1 and MSH2 expression on breast cancer cells BT-549
Journal of Advanced Pharmaceutical Technology & Research, 2023 Due to its genetic and phenotypic heterogeneity, breast cancer is very difficult to eliminate. The harmful consequences of conventional therapies like radiation and chemotherapy have prompted the search for organic-based alternatives. Hesperetin (HSP), a
Assim Khattab Hasan +2 more
doaj +1 more source
Mutators Enhance Adaptive Micro-Evolution in Pathogenic Microbes
Microorganisms, 2022 Adaptation to the changing environmental conditions experienced within a host requires genetic diversity within a microbial population. Genetic diversity arises from mutations which occur due to DNA damage from exposure to exogenous environmental ...
Kylie J. Boyce
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Zhongguo linchuang yanjiu, 2023 Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
doaj +1 more source
Haseki Tıp Bülteni, 2021 Aim:Colorectal cancer (CRC) is the third most common cancer in the world. About 5-6% of all CRCs have a hereditary inheritance related with germline mutations.
Mehmet Buğrahan Düz
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Hereditary Cancer in Clinical Practice, 2008 DNA testing is recommended in families fulfilling at least "suspected HNPCC" criteria. After exclusion of FAP (characteristic FAP features include polyposis, congenital hypertrophy of the retinal pigment epithelium, cysts and osteomata of bones of the maxilla and mandible, desmoid tumours), immunohistochemical analyses (IHC) of MLH1, MSH2 and MSH6 ...
Kurzawski Grzegorz +2 more
openaire +3 more sources
MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. [PDF]
PLoS Genetics, 2009 Myotonic dystrophy type 1 (DM1) is associated with one of the most highly unstable CTG*CAG repeat expansions. The formation of further repeat expansions in transgenic mice carrying expanded CTG*CAG tracts requires the mismatch repair (MMR) proteins MSH2 ...
Stéphanie Tomé +6 more
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Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
Genes and Environment, 2021 Background Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the type and frequency of mutations ...
Yasunobu Aoki +6 more
doaj +1 more source
Nature Communications, 2023 Meiotic crossovers can be formed through the interfering pathway, in which one crossover prevents another from forming nearby, or by an independent non-interfering pathway.
Julia Dluzewska +6 more
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