Results 31 to 40 of about 42,200 (256)

MSH2 Loss in Primary Prostate Cancer [PDF]

Clinical Cancer Research, 2017
Abstract Purpose: Inactivation of mismatch repair (MMR) genes may predict sensitivity to immunotherapy in metastatic prostate cancers. We studied primary prostate tumors with MMR defects. Experimental Design: A total of 1,133 primary prostatic adenocarcinomas and 43 prostatic small cell carcinomas (NEPC) were ...
Liana B, Guedes, Emmanuel S, Antonarakis, Michael T, Schweizer, Nooshin, Mirkheshti, Fawaz, Almutairi, Jong Chul, Park, Stephanie, Glavaris, Jessica, Hicks, Mario A, Eisenberger, Angelo M, De Marzo, Jonathan I, Epstein, William B, Isaacs, James R, Eshleman, Colin C, Pritchard, Tamara L, Lotan   +14 more
openaire   +2 more sources

Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX [PDF]

, 2018
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX ...
Gbolahan, Olumide, Hancock, Brad A., O'Neil, Bert H., Radovich, Milan, Sehdev, Amikar, Shahda, Safi, Stanley, Melissa, Wan, Jun, Wu, Howard H.   +8 more
core   +1 more source

Msh2 blocks an alternative mechanism for non-homologous tail removal during single-strand annealing in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2009
Chromosomal translocations are frequently observed in cells exposed to agents that cause DNA double-strand breaks (DSBs), such as ionizing radiation and chemotherapeutic drugs, and are often associated with tumors in mammals.
Glenn M Manthey, Nilan Naik, Adam M Bailis   +2 more
doaj   +1 more source

MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination

G3: Genes, Genomes, Genetics, 2021
In eukaryotes, DNA mismatch recognition is accomplished by the highly conserved MutSα (Msh2/Msh6) and MutSβ (Msh2/Msh3) complexes.
Tim Arlow, Junwon Kim, Joanna E. Haye-Bertolozzi, Cristina Balbás Martínez, Caitlin Fay, Emma Zorensky, Mark D. Rose, Alison E. Gammie   +7 more
doaj   +1 more source

Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues. [PDF]

, 1997
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated
Aebi, S, Christen, RD, Fink, D, Howell, SB, Kim, HK, Nebel, S, Zheng, H   +6 more
core   +1 more source

Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis [PDF]

, 2020
Atypical polypoid adenomyoma (APA) is a rare uterine lesion constituted by atypical endometrioid glands, squamous morules, and myofibromatous stroma. We aimed to assess the immunophenotype of the 3 components of APA, with regard to its pathogenesis and ...
Aggarwal, Ayhan, Chiarelli, Di Palma, Fukunaga, Giampaolino, Heatley, Horita, Houghton, Jiang, Kuwashima, Lin, Longacre, Lu, Ma, Mazur, McAlpine, McCluggage, McCluggage, Moher, Nei, Nomura, Nomura, Němejcová, Ohishi, Ota, Raffone, Raffone, Raffone, Raffone, Raffone, Raffone, Ramos, Stelloo, Strickland, Takahashi, Talhouk, Terada, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Young, Zhang   +46 more
core   +1 more source

Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners [PDF]

Nature Structural & Molecular Biology, 2018
Eukaryotic DNA mismatch repair (MMR) involves both exonuclease 1 (Exo1)-dependent and Exo1-independent pathways. We found that the unstructured C-terminal domain of Saccharomyces cerevisiae Exo1 contains two MutS homolog 2 (Msh2)-interacting peptide (SHIP) boxes downstream from the MutL homolog 1 (Mlh1)-interacting peptide (MIP) box.
Eva M. Goellner, Christopher D. Putnam, William J. Graham, Christine M. Rahal, Bin-Zhong Li, Richard D. Kolodner   +5 more
openaire   +4 more sources

The Formation of a Stable Sliding Clamp Discriminates MSH2-MSH3 and MSH2-MSH6 Mismatch Interaction [PDF]

, 2021
ABSTRACTMutS homologs (MSH) are highly conserved core components of DNA mismatch repair (MMR). Mismatch recognition provokes ATP-binding by MSH proteins that drives a conformational transition from a short-lived lesion-searching clamp to an extremely stable sliding clamp on the DNA. Once on DNA the MSH sliding clamps provide a platform for the assembly
Brooke M. Britton, James A. London, Juana Martin-Lopez, Nathan D. Jones, Jiaquan Liu, Jong-Bong Lee, Richard Fishel   +6 more
openaire   +1 more source

MSH2 and CXCR4 involvement in malignant VIPoma [PDF]

World Journal of Surgical Oncology, 2012
Abstract Background Vasoactive intestinal polypeptide secreting tumors(VIPomas) are rare endocrine tumors of the pancreas with an estimated incidence of 0.1 per million per year. The molecular mechanisms that mediate development of VIPomas are poorly investigated and require definition.
Kupka, Susan, Northoff, Hinnak, Sotlar, Karl, Bock, Claus-Thomas, Kandolf, Reinhard, Traub, Frank, Zieker, Derek Anthony Gerald, Müller, Sven, Königsrainer, Ingmar, Königsrainer, Alfred   +9 more
openaire   +4 more sources

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6 [PDF]

Biochemistry, 2020
DNA mismatch repair (MMR) is an important postreplication process that eliminates mispaired or unpaired nucleotides to ensure genomic replication fidelity. In humans, Msh2-Msh6 and Msh2-Msh3 are the two mismatch repair initiation factors that recognize DNA lesions.
Arumay Pal, Harry M. Greenblatt, Yaakov Levy   +2 more
openaire   +2 more sources