Results 71 to 80 of about 23,834 (214)

Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation

Scientific Reports
The present study investigated the relationship between MSH3 and MSH6 genes in lung cancer patients. Genotyping of lung cancer patients and healthy controls was performed. Odds ratio values were calculated and survival analysis performed.
Sidhartha Singh, Navneet Singh, Parth Sarthi Sen Gupta, Saroj Kumar Panda, Isha Dhamija, Deepak Nathiya, Sandeep Kumar, Siddharth Sharma   +7 more
doaj   +1 more source

A case of Turcot’s syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report

BMC Medical Genetics, 2020
Background Lynch syndrome (LS), which is known as a hereditary cancer syndrome, is distinguished by microsatellite instability, represented by the altered number of repetitive sequences in the coding and/or non-coding region. Immunohistochemical staining
Shintaro Akabane, Takao Hinoi, Kiwamu Akagi, Hideki Yamamoto, Haruki Sada, Yosuke Shimizu, Wataru Shimizu, Takeshi Sudo, Takashi Onoe, Kohei Ishiyama, Takahisa Suzuki, Hirofumi Tazawa, Naoto Hadano, Toshihiro Misumi, Masato Kojima, Haruna Kubota, Daiki Taniyama, Kazuya Kuraoka, Hirotaka Tashiro   +18 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Loss of MSH6 reduces the frequency of paternally and maternally transmitted expansions.

, 2016
The % of alleles with the indicated number of repeats added or lost seen on transmission of a PM allele with ~160 repeats from Msh6+/+, Msh6+/- and Msh6-/- parents.
Rachel Lokanga (3151983), Inbal Gazy (778510), Karen Usdin (88334), Kimaada Allette (3151986), Di Wu (23906), Xiao-Nan Zhao (3151989)   +5 more
core   +1 more source

GenProb‐PCSM: A Simplified Weighted Germline Score for Prostate Cancer‐Specific Mortality

The Prostate, EarlyView.
ABSTRACT Background We previously developed a tier‐based germline classification using the National Comprehensive Cancer Network (NCCN)‐recommended DNA damage repair (DDR) genes and KLK3 I179T to predict prostate cancer (PCa)‐specific mortality (PCSM).
Jun Wei, Zhuqing Shi, Lucy Lu, John Wang, Julian Xu, Ashley J. Mulford, Huy Tran, Annabelle Ashworth, S. Lilly Zheng, Alan R. Sanders, William B. Issacs, Jun Luo, Brian Helfand, Jim Lu, Jianfeng Xu   +14 more
wiley   +1 more source

CHEK2, MCM3 and MSH6 may have a Potential Role as Molecular Markers of Screening in the Detection of Cervical Premalignant and Malignant Lesions: A Scoping Review

JLUMHS
Lesions of the uterine cervix, including neoplasia, are the foremost cause of female deaths worldwide. Cervical malignancy ranks as the third most common gynecological malignancy globally, with an increasing prevalence reported in Asia each year.
Gulfishan Zameer, Maham Javed, Saima Zaki, Bushra Nisar, Saba Khaliq, Nadia Naseem   +5 more
doaj   +1 more source

Clinical and Molecular Characterization of Brazilian Patients Suspected to Have Lynch Syndrome.

PLoS ONE, 2015
Lynch syndrome (LS) accounts for 3-5% of all colorectal cancers (CRC) and is inherited in an autosomal dominant fashion. This syndrome is characterized by early CRC onset, high incidence of tumors in the ascending colon, excess of synchronous ...
Felipe Carneiro da Silva, José Roberto de Oliveira Ferreira, Giovana Tardin Torrezan, Márcia Cristina Pena Figueiredo, Érika Maria Monteiro Santos, Wilson Toshihiko Nakagawa, Rafael Canfield Brianese, Ligia Petrolini de Oliveira, Maria Dirlei Begnani, Samuel Aguiar-Junior, Benedito Mauro Rossi, Fábio de Oliveira Ferreira, Dirce Maria Carraro   +12 more
doaj   +1 more source

What Happens After Menopause (WHAM)? A Progress Report of a Prospective Controlled Study of Women After Pre‐Menopausal Risk‐Reducing Bilateral Salpingo‐Oophorectomy

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price, Pauline M. Maki, Samar R. El Khoudary, Alison Brand, Rakibul M. Islam, Susan M. Domchek, Hadine Joffe, Gita D. Mishra, Katrina M. Moss, Fiona C. Baker, Sabine Braat, John D. Wark, Martha Hickey   +12 more
wiley   +1 more source

Early-stage endometrioid carcinoma with MSH6 protein deficiency: pitfalls in the diagnostic interpretation of microsatellite instability

Frontiers in Oncology
ObjectiveMicrosatellite instability (MSI)/mismatch repair (MMR) protein testing is important for Lynch syndrome (LS) identification, prognostic stratification, and immune checkpoint inhibitor screening in many solid malignancies. MSH6, an MMR protein, is
Cheng Wang, Cheng Wang, Dongni Liang, Dongni Liang, Wei Wang, Wei Wang, Wei Kuang, Wei Kuang, Juan Zou, Juan Zou, Jing Zeng, Jing Zeng, Min Feng, Min Feng   +13 more
doaj   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source