Results 91 to 100 of about 23,834 (214)

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: Impact on counseling and surveillance

, 2004
Background & Aims: Hereditary nonpolyposis colorectal carcinoma (HNPCC) is caused by a mutated mismatch repair (MMR) gene. The aim of our study was to determine the cumulative risk of developing cancer in a large series of MSH6 mutation carriers ...
Genuardi, M
core   +2 more sources

Mutation in the Mismatch Repair Gene Msh6 Causes Cancer Susceptibility [PDF]

, 1997
Mice carrying a null mutation in the mismatch repair gene Msh6 were generated by gene targeting. Cells that were homozygous for the mutation did not produce any detectable MSH6 protein, and extracts prepared from these cells were defective for repair of ...
Pollard, Jeffrey W, Crouse, Gray F, Liedtke, Wolfgang, Kane, Michael F, Kunkel, Thomas, Kucherlapati, Raju, Umar, Asad, Fan, Kunhua, Yang, Kan, Kolodner, Richard, Edelmann, Winfried, Cohen, Paula E, Yu, Nianjun, Lipkin, Martin, Lipford, James R, Heyer, Joerg, Lau, Kirkland   +16 more
core   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Contribution of Msh2 and Msh6 Subunits to the Asymmetric ATPase and DNA Mismatch Binding Activities of \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e Msh2–Msh6 Mismatch Repair Protein [PDF]

, 2006
Previous analyses of both Thermus aquaticus MutS homodimer and Saccharomyces cerevisiae Msh2–Msh6 heterodimer have revealed that the subunits in these protein complexes bind and hydrolyze ATP asymmetrically, emulating their asymmetric DNA binding ...
Khubchandani, Sapna, Chen, Siying, Antony, Edwin, Hingorani, Manju M.   +3 more
core  

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy, Annette Sereika, Karen Kaul, Megan Parilla, Mir B. Alikhan, Michael Bouma, Dyson Wake, Peter J. Hulick, Henry M. Dunnenberger, Linda M. Sabatini, Mathew Yang, Kathy A. Mangold, Erin Proctor, Nicholas Evans, Nicholas Miller, Donald L. Helseth Jr, Darryck Maurer, Justin Brueck, Janardan Khandekar, Bruce Brockstein   +19 more
wiley   +1 more source

The Role of Noncoding RNA in MGMT‐Positive Glioblastoma: A Narrative Review

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary malignant tumor of the central nervous system and is characterized by rapid progression, frequent recurrence, and poor survival outcomes. The current standard of care, comprising maximal safe surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ), has ...
Junfeng Zhao, Jiaxuan Chen, Yingrui Bai, Ying Li, Yiming Han, Chuankun Han, Yintao Li   +6 more
wiley   +1 more source

Mutating lysine 336 in Msh6 does not appear to affect DNA mismatch repair in Saccharomyces cerevisiae [PDF]

Defects in the DNA mismatch repair process results in the accumulation of mutations and disease. Mutations in MSH6 and MSH2, encoding for the subunits of the MutSα complex, are often responsible for Constitutional Mismatch Repair Deficiency (CMMRD) and ...
Reese, Daniel, Haye-Bertolozzi, Joanna E, Daveron, Kalila, Bennafield, Noa, Bolden, Christopher, Thompson, Anthony   +5 more
core   +1 more source

CRISPR‐based therapeutic and modelling approaches in Huntington's disease: Progress, challenges and future directions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Clustered regularly interspaced short palindromic repeat (CRISPR) is transforming Huntington's disease research through allele‐selective huntingtin (HTT) targeting, transcriptional and RNA suppression, and advanced disease modelling. Progress towards precision therapy depends on safe central nervous system (CNS) delivery, reduced off‐target and immune ...
Kairat Zhakipbekov, Surayyo Eshkabilova, Zokir Raximov, Sharof Eshonov, Abdusaid Khasanov, Ziyodulla Tokhtamurod, Axmadjan Ashurmetov, Avazbek Abduraxmanov, Niyozbek Abdurakhmonov, Elmurod Eshqobilov, Seyed Mohsen Mirhosseini, Amir Arsalan Ghahari   +11 more
wiley   +1 more source

Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Estradiol (E2) promotes tumor progression in ERα‐low endometrial cancer through the GPER/SphK1/ERK1/2 signaling axis. E2 binding to GPER activates SphK1 and downstream ERK1/2, upregulating Cyclin D1, Cyclin E1, and MMP‐9 to drive cell proliferation, migration, and invasion.
Xiuwen Wang, Haofei Sun, Xin Wen, Weiwei Xin, Zhandong Hu, Zhongwei Zhao, Lizhi Zhang   +6 more
wiley   +1 more source

Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree [PDF]

, 2001
Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer. HNPCC is most frequently caused by germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1 ...
Breuning, M. H., van der Meer, C., Wijnen, J.T. (Juul), Bröcker-Vriends, A. H., Vasen, H. F., Fodde, R. (Riccardo), Niermeijer, MF, Lindhout, D. (Dick), Lindhout, D., van Krimpen, C., Meer, C.A. (Conny) van der, Hofstra, R.M.W. (Robert), Wagner, A., Bröcker-Vriends, A, Zwinderman, A. H., Hofstra, R., Tops, C., Morreau, H, Meijers-Heijboer, E.J. (Hanne), Vasen, H.F. (Hans), Niermeijer, Martinus, de Leeuw, W. J., Zwinderman, AH, Morreau, H., Fodde, R, Vasen, HFA, Wagner, Anja, Tops, C. (Carli), Wagner, A. (Anja), van Wijnen, J (Juul), Brocker-Vriends, AHJT, Brocker-Vriends, A.H., Niermeijer, M. F., Bik, E.C. (Elsa), Meijers-Heijboer, E. J., Hendriks, Y, van der Meer, C, Niermeijer, M.F. (Martinus), Lindhout, D, Krimpen, C. (Cees) van, Hofstra, R, van Krimpen, C, Lindhout, D (Dick), Breuning, M.H. (Martijn), de Leeuw, WJF, Morreau, H. (Hans), Wijnen, J., Bik, E., Wagner, Anja; id_orcid, Zwinderman, A.H. (Ailko), Tops, C, Breuning, MH, Meijers-Heijboer, EJ, Leeuw, W.J. de, Hendriks, Y., Bik, E, Cornelisse, C. J., Cornelisse, C.J. (Cees), Cornelisse, CJ, Fodde, R., Wijnen, J   +60 more
core   +2 more sources