Results 101 to 110 of about 32,048 (238)

Socioeconomic and Demographic Factors in Genetic Testing Utilization Among Advanced Prostate Cancer Patients

The Prostate, Volume 86, Issue 8, Page 941-948, June 2026.
ABSTRACT Purpose Germline genetic testing in patients with advanced prostate cancer (PCa) is underutilized and hypothesized to be impacted by socioeconomic and demographic factors. This single institution, retrospective study assessed the association of income and social vulnerability with genetic referrals and testing.
Alexandra T. Skowron, Karen Childers, Courtney M. Rose, Kyle C. McElyea, Avery K. Supernois, Yousuf Hussain, Mohammed Baseer, Sunita Ghosh, Clara Hwang   +8 more
wiley   +1 more source

Attitudes Toward Updated Genetic Testing Among Patients with Unexplained Mismatch Repair Deficiency [PDF]

, 2018
Individuals who have colorectal cancer (CRC) or endometrial cancer (EC) displaying loss of immunohistochemical (IHC) staining of one or more mismatch repair (MMR) proteins without a causative germline mutation are said to have unexplained mismatch repair
Omark, Jessica
core   +1 more source

Evaluation of current prediction models for Lynch syndrome: updating the PREMM5 model to identify PMS2 mutation carriers [PDF]

, 2017
Until recently, no prediction models for Lynch syndrome (LS) had been validated for PMS2 mutation carriers. We aimed to evaluate MMRpredict and PREMM5 in a clinical cohort and for PMS2 mutation carriers specifically.
Bruno, M.J. (Marco), Dinjens, W.N.M. (Winand), Dubbink, H.J. (Erik Jan), Goverde, A. (Anne), Hofstra, R.M.W. (Robert), Nieboer, D. (Daan), Ouweland, A.M.W. (Ans) van den, Spaander, M.C.W. (Manon), Steyerberg, E.W. (Ewout), Ten Broeke, S.W. (Sanne W.), Tops, C. (Cmj), Wagner, A. (Anja)   +11 more
core   +1 more source

Cancer Risks for Msh6 Pathogenic Variant Carriers

European Journal of Cancer
Abstract Introduction Lynch syndrome (LS) is a hereditary cancer syndrome caused by (likely) pathogenic variants (LP/P) in DNA mismatch repair genes, including MSH6 . It is associated with elevated lifetime risks for colorectal cancer (CRC),
A.S. van der Werf – ‘t Lam, J.G. Dowty, M. Italia, A.C. Bakker, F. Koops, F. Bleeker, E. Gomez – Garcia, L.P. van Hest, H.J.P. Gille, M.C. Cornips, M.M. de Jong, T.G.W. Letteboer, F.A.M. Duijkers, A. Wagner, E.L. Eikenboom, C.J. van Asperen, S.W. Bajwa – ten Broeke, A.K. Win, M.A. Jenkins, M. Nielsen   +19 more
openaire   +5 more sources

Germline genetic testing among patients with pancreatic adenocarcinoma: A Pancreatic Cancer Action Network patient survey

Cancer, Volume 132, Issue 10, 15 May 2026.
Abstract Background Approximately 10%–15% of patients with pancreatic ductal adenocarcinoma (PDAC) harbor pathogenic germline genetic alterations with direct therapeutic and hereditary cancer implications, leading to guideline recommendations for universal germline genetic testing regardless of family history.
Udhayvir S. Grewal, Rishi R. Patel, Bradley T. Loeffler, Sydney Rathjens, Kawther Abdilleh, Fatima Zelada‐Arenas, Nicholas J. Hornstein, Timothy J. Brown, Seth J. Concors, Naomi H. Fei, Saima Sharif, Chandrikha Chandrasekharan   +11 more
wiley   +1 more source

Do all colorectal mucinous adenocarcinomas arise via the serrated neoplasia pathway?

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract Colorectal mucinous adenocarcinomas (MACs) and serrated adenocarcinomas (SACs) demonstrate considerable overlap in morphological and molecular features, suggesting a spectrum rather than two distinct tumour types. This study investigates the presence of serrated morphological features, precursors, and molecular features in a large cohort of ...
Anne‐Marie Vos, Peter H van Zwam, Natasja Rutgers, Shannon van Vliet, Elisa Vink‐Börger, Rachel S van der Post, Femke Simmer, Iris D Nagtegaal   +7 more
wiley   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, Volume 10, Issue 3, Page 760-769, May 2026.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Germline Pathogenic Variants in HER2‐Positive Breast Cancer: Spectrum and Clinical Implications in a High‐Risk Chinese Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective Hereditary cancer risk assessment has predominantly focused on HER2‐negative breast cancer (BC), with limited characterization of germline pathogenic variants (GPVs) in HER2‐positive disease. This study aimed to delineate the prevalence, clinicopathological correlates, and clinical implications of GPVs in a cohort of HER2‐positive BC
Lijia Zhou, Mengqian Ni, Anli Yang, Qingru Zhou, Daining Wang, Shu Dun, Fei Xu, Jiajia Huang, Xiwen Bi, Wen Xia, Ruoxi Hong, Qiufan Zheng, Meiting Chen, Kuikui Jiang, Jun Tang, Xi Wang, Zhongyu Yuan, Shusen Wang, Yanxia Shi, Fang Wang, Xin An   +20 more
wiley   +1 more source

Efficacy of Fertility‐Sparing Treatment With Progestin Is Associated With Different Molecular Classification in Endometrial Carcinoma and Atypical Endometrial Hyperplasia

Cancer Medicine, Volume 15, Issue 5, May 2026.
Molecular profiles and outcomes of CR rate in 74 cases. ABSTRACT Objective To investigate the impact of various molecular characteristics on the outcomes of fertility‐preserving therapy in patients with endometrial cancer (EC) and atypical endometrial hyperplasia (AEH).
Xue‐Qian Qian, Hao‐Hui Fu, Xiao‐Yun Wan, Dong‐Xiao Hu, Yuan‐Ming Shen   +4 more
wiley   +1 more source

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population. [PDF]

, 2010
Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Bashiardes, E, Cariolou, MA, Daniel, M, Hadjisavvas, A, Kakouri, E, Loizidou, MA, Marcou, Y, Michael, T, Neuhausen, SL, Newbold, RF   +9 more
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