Results 101 to 110 of about 23,834 (214)

Automatic Conversion of NICE Guidelines to an Executable Computational Model Using Large Language Models

Learning Health Systems, Volume 10, Issue 4, October 2026.
ABSTRACT Introduction The UK National Institute for Health and Care Excellence (NICE) produce guidelines that provide evidence‐based recommendations to support clinical care across England and Wales, but remain available in unstructured natural language form.
Ashvin Gupta, Denys Prociuk, Alessandra Russo, Brendan C. Delaney   +3 more
wiley   +1 more source

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer

MedComm, Volume 7, Issue 10, October 2026.
Cooccurrence of dMMR and HRD in colorectal cancer. On the left blue shaded area, the dMMR (deficient mismatch repair) pathway is shown as a result of the loss of key DNA repair genes MLH1, MSH2, MSH6, and PMS2, which cause single strand breaks.
Xu Zhang, Hao Xu, Kailai Wang, Wangxiong Hu   +3 more
wiley   +1 more source

Conformational Change in MSH2-MSH6 upon Binding DNA Coupled to ATPase Activity [PDF]

, 2009
Postreplication DNA mismatch repair is initiated by the eukaryotic protein MSH2-MSH6 or the prokaryotic protein MutS, both showing overall conserved structure and functionality.
Feig, Michael, Mukherjee, Shayantani
core   +1 more source

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, Volume 138, Issue 4, Page 600-606, October 2026.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source

MSH6 and PMS2 expression in colorectal carcinoma

Bioinformation
Microsatellite instability (MSI) is a key feature in colorectal carcinomas (CRCs), but its role in diagnosis and prognosis, particularly through immunohistochemical markers like MSH6 and PMS2, remains underexplored. Conducted at Sree Balaji Medical College and Hospital, 50 histologically confirmed CRC samples were analyzed.
M, Safin, S, Marylilly, MS, Janhavi
openaire   +2 more sources

Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study

Cancer Treatment and Research Communications
Background: Recently, some evidence emphasized the value of MSH2 and MSH6 inactivation and their hypermutation in predicting different cancers. The present consideration is to evaluate the value of MSH2 and MSH6 protein deficient studied by the ...
Fatemeh Sharbati, Hedieh Moradi Tabriz, Elham Nazar   +2 more
doaj   +1 more source

DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters

Scientific Reports
Lung cancer (LC) is a crucial rapidly developing disease. In Egypt, it is one of the five most frequent cancers. Little is known about the impact of deleted mismatch repair genes and its correlation to clinicopathological characteristics.
Mayada Saad Farrag, Heba Wagih Abdelwahab, Amr Abdellateef, Nahla Anber, Mohamed Adel Ellayeh, Dalia Tawfeek Hussein, Ahmed Ramadan Eldesoky, Heba Sheta   +7 more
doaj   +1 more source

The loss of MSH6 does not affect the levels of MSH3 in brain and testes.

, 2016
Equivalent amounts of total protein from brain, testes and ovary and nuclear extracts from liver of three 6-month old WT, Msh3-/- and Msh6-/- and Msh2-/- mice were subjected to electrophoresis and western blotting using the MSH2, MSH3 and MSH6 antibodies
Rachel Lokanga (3151983), Inbal Gazy (778510), Karen Usdin (88334), Kimaada Allette (3151986), Di Wu (23906), Xiao-Nan Zhao (3151989)   +5 more
core   +1 more source

Germline MLH1 and MSH6 mutations from two Lynch syndrome families identified in a patient with early-onset of endometrial cancer: A case report

Gynecologic Oncology Reports
Introduction: Lynch syndrome is caused by a germline mutation in mismatch repair (MMR) genes, leading to the loss of expression of MMR heterodimers, either MLH1/PMS2 or MSH2/MSH6, or isolated loss of PMS2 or MSH6.
Yi-Ching Huang, Peng-Chan Lin, Pei-Ying Wu, Nai-Syuan Chen, Meng-Ru Shen, Yu-Min Yeh, Ya-Min Cheng   +6 more
doaj   +1 more source

Rare germline mutation and MSH2-&MSH6 + expression in a double primary carcinoma of colorectal carcinoma and endometrial carcinoma: a case report

Diagnostic Pathology
Background Multiple primary malignancies are rare in cancer patients, and risk factors may include genetics, viral infection, smoking, radiation, and other environmental factors. Lynch syndrome (LS) is the most prevalent form of hereditary predisposition
Tiansong Zhang, Xiaoqiang Huang, Wenjie Liu, Xiulan Ling, Zhenping Su, Mengwei Huang, Shuanlong Che   +6 more
doaj   +1 more source