Results 121 to 130 of about 32,048 (238)

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area

Histopathology, Volume 88, Issue 6, Page 1221-1228, May 2026.
This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer, Zainab Al‐Shamma, Martin Köbel, Ingrid Ferreira, Paul W. Harms, Thomas Brenn   +5 more
wiley   +1 more source

DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters

Scientific Reports
Lung cancer (LC) is a crucial rapidly developing disease. In Egypt, it is one of the five most frequent cancers. Little is known about the impact of deleted mismatch repair genes and its correlation to clinicopathological characteristics.
Mayada Saad Farrag, Heba Wagih Abdelwahab, Amr Abdellateef, Nahla Anber, Mohamed Adel Ellayeh, Dalia Tawfeek Hussein, Ahmed Ramadan Eldesoky, Heba Sheta   +7 more
doaj   +1 more source

Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response

Journal of Nucleic Acids, 2010
Mismatch repair proteins modulate the cytotoxicity of several chemotherapeutic agents. We have recently proposed a “death conformation” of the MutS homologous proteins that is distinguishable from their “repair conformation.” This conformation can be ...
Aksana Vasilyeva, Jill E. Clodfelter, Michael J. Gorczynski, Anthony R. Gerardi, S. Bruce King, Freddie Salsbury, Karin D. Scarpinato   +6 more
doaj   +1 more source

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, Volume 88, Issue 6, Page 1115-1125, May 2026.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source

Novel MSH6 exon 5–6 skipping variant in a Taiwanese family with Lynch syndrome: implications for genetic testing and cancer management

Molecular Cytogenetics
Lynch syndrome is an autosomal dominant disorder predisposing individuals to colorectal and other cancers, primarily caused by variants in mismatch repair genes.
Ting-Yao Wang, Chao-Yu Chen, Huei-Chieh Chuang, Yuan-Yuan Jiang, Jrhau Lung   +4 more
doaj   +1 more source

MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils [PDF]

, 2017
The mammalian antibody repertoire is shaped by somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin (Ig) loci of B lymphocytes.
Campo, Vanina A., Di Noia, Javier M., Firka, Daniel, Horb, Lori, Jiricny, Josef, Kaden, Svenja, Patenaude, Anne-Marie   +6 more
core  

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

Journal of Oral Pathology &Medicine, Volume 55, Issue 5, Page 611-615, May 2026.
ABSTRACT Introduction While the prevalence of microsatellite instability (MSI) is low in the whole head and neck squamous cell carcinoma (HNSCC) population, it has been suggested to be more prominent in tumors of non‐smokers. Therefore, the goal of this study was to determine the presence of MSI in a cohort of well‐defined HNSCC of non‐smokers and non ...
F. J. Mulder, T. F. B. Gielgens, E. J. de Ruiter, R. de Bree, M. F. C. M. van den Hout, B. Kremer, S. M. Willems, E. J. M. Speel   +7 more
wiley   +1 more source

Germline MLH1 and MSH6 mutations from two Lynch syndrome families identified in a patient with early-onset of endometrial cancer: A case report

Gynecologic Oncology Reports
Introduction: Lynch syndrome is caused by a germline mutation in mismatch repair (MMR) genes, leading to the loss of expression of MMR heterodimers, either MLH1/PMS2 or MSH2/MSH6, or isolated loss of PMS2 or MSH6.
Yi-Ching Huang, Peng-Chan Lin, Pei-Ying Wu, Nai-Syuan Chen, Meng-Ru Shen, Yu-Min Yeh, Ya-Min Cheng   +6 more
doaj   +1 more source

Involvement of large rearrangements in MSH6 and PMS2 genes in southern Italian patients with Lynch syndrome [PDF]

, 2018
Background and aim of the work: The Lynch Syndrome (LS) is associated with germline mutations in one of the MisMatch Repair (MMR) genes. Most of germline mutations are point variants, followed by large rearrangements that account to 15-55% of all ...
Cudia, B., Duraturo, F., Izzo, P., Liccardo, R., Lo Monte, A. I.   +4 more
core   +1 more source

Rare germline mutation and MSH2-&MSH6 + expression in a double primary carcinoma of colorectal carcinoma and endometrial carcinoma: a case report

Diagnostic Pathology
Background Multiple primary malignancies are rare in cancer patients, and risk factors may include genetics, viral infection, smoking, radiation, and other environmental factors. Lynch syndrome (LS) is the most prevalent form of hereditary predisposition
Tiansong Zhang, Xiaoqiang Huang, Wenjie Liu, Xiulan Ling, Zhenping Su, Mengwei Huang, Shuanlong Che   +6 more
doaj   +1 more source