Results 111 to 120 of about 32,048 (238)

A Novel Nomogram Incorporating the Aggregate Index of Systemic Inflammation, Clinicopathological Parameters and Molecular Classification to Predict Recurrence of Endometrial Cancer: A Multi‐Center Retrospective Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT This study evaluated the aggregate index of systemic inflammation (AISI) for predicting postoperative recurrence in endometrial cancer (EC). A total of 1557 patients were enrolled and divided into training (n = 1030) and validation (n = 527) cohorts. The optimal AISI cutoff was determined by ROC curve analysis.
Chenfan Tian, Na Zeng, Yuan Tu, Chunxia Gong, Jiaxin Yu, Kunying Rao, Peng Jiang   +6 more
wiley   +1 more source

Advanced Gastric Cancer Presenting as a Giant Subepithelial Lesion: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
A giant subepithelial lesion. ABSTRACT Gastric cancer may occasionally present with a subepithelial lesion‐like appearance. When a gastric gastrointestinal stromal tumor (GIST) is suspected preoperatively without definitive pathological confirmation, intraoperative frozen section analysis is recommended to prevent inappropriate surgical intervention.
Ji Sun, Qian Wang, Yuemei Hu, Ping Yin, Ziming Zhou, Hui Chen, Xiaoming Zhu   +6 more
wiley   +1 more source

Characterisation of tumor‐infiltrating gamma‐delta T cells in human colorectal cancer with MHC‐I loss

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives Gamma‐delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhibit an intrinsic tropism for the tumor microenvironment, largely driven by their capacity to recognize stress‐induced antigens ...
Tianming A Li, Luke T Quigley, Kok Fei Chan, David S Williams, Lisa A Mielke, Andreas Behren, Jessica Da Gama Duarte   +6 more
wiley   +1 more source

Presumed TP53 mosaicism: variants detected using a NGS hereditary cancer multigene panel [PDF]

, 2019
Aims/Context: NGS multigene panels are routinely used to identify germline pathogenic variants in cancer susceptibility genes. In addition, NGS allows the identification of low-level mosaicism events that may not be detectable by conventional Sanger ...
Gonçalves, João, Rodrigues, Márcia, Rodrigues, Pedro, Silva, Catarina, Theisen, Patrícia, Vieira, Luís   +5 more
core  

Outcomes from the English National Lynch Syndrome transformation project

International Journal of Cancer, Volume 158, Issue 9, Page 2369-2379, 1 May 2026.
What's new? The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation Project in England aims to ensure that patients newly diagnosed with colorectal or endometrial cancer are offered testing for the syndrome ...
Kevin J. Monahan, Paul Fleming, Neil A. J. Ryan, Laura Monje‐Garcia, Ruth Armstrong, David N. Church, Jackie Cook, Fiona Lalloo, Sally Lane, Frank D. McDermott, Tracie Miles, Corinne Mallinson, Steven A. Hardy, Simone Gelinas, Francesca Faravelli, Frances Elmslie, Adam C. Shaw   +16 more
wiley   +1 more source

DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High‐Grade Serous Ovarian Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Extracellular vesicles (EVs), including exosomes, circulate in body fluids and carry pathological genomic information. High‐grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, characterized predominantly by copy number variations (CNVs).
Ryosuke Uekusa, Akira Yokoi, Mayu Ukai, Kosuke Yoshida, Kunanon Chattrairat, Takao Yasui, Yasuhide Inokuma, Masami Kitagawa, Eri Asano‐Inami, Masato Yoshihara, Satoshi Tamauchi, Nobuhisa Yoshikawa, Kaoru Niimi, Juntaro Matsuzaki, Takahiro Ochiya, Anil K. Sood, Yusuke Yamamoto, Hiroaki Kajiyama   +17 more
wiley   +1 more source

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium. [PDF]

, 2018
Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and ...
GLASS Consortium
core  

Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation

The Prostate, Volume 86, Issue 6, Page 727-731, May 2026.
ABSTRACT Background Methyl Methanesulfonate‐Sensitivity Protein 22‐Like (MMS22L) plays a key role in homology‐directed DNA repair, and experimental models have shown that its loss confers sensitivity to Poly (ADP‐ribose) polymerase inhibitors (PARPi).
Mayuko Kanayama, Violet A. Daniels, Marta Gielzak, Alex Brame, Misop Han, Li Jia, Jianfeng Xu, Tamara L. Lotan, Mario A. Eisenberger, Catherine H. Marshall, Patrick C. Walsh, William B. Isaacs, Jun Luo   +12 more
wiley   +1 more source

Clinical and Genetic Landscape of Glioblastoma, IDH‐Wildtype With FGFR Gene Family Alterations

Cancer Science, Volume 117, Issue 5, Page 1455-1468, May 2026.
We analyzed 1076 cases of glioblastoma, IDH‐wildtype (GBM, IDH‐wt) using the C‐CAT genomic database to clarify the clinical and genetic features of FGFR alterations. FGFR::TACC fusions and FGFR1 mutations were identified in distinct subsets and were associated with unique co‐mutation patterns.
Yasuhito Kegoya, Yoshihiro Otani, Ryo Mizuta, Ryosuke Ikemachi, Mako Kamiura, Joji Ishida, Shinichi Toyooka, Daisuke Ennishi, Shuta Tomida, Shota Tanaka   +9 more
wiley   +1 more source

Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study

Cancer Treatment and Research Communications
Background: Recently, some evidence emphasized the value of MSH2 and MSH6 inactivation and their hypermutation in predicting different cancers. The present consideration is to evaluate the value of MSH2 and MSH6 protein deficient studied by the ...
Fatemeh Sharbati, Hedieh Moradi Tabriz, Elham Nazar   +2 more
doaj   +1 more source