Results 141 to 150 of about 2,567 (167)

Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells

FEBS Letters, 2015
To investigate TRAIL resistance mechanisms in hepatocellular carcinoma (HCC), we isolated a stable TRAIL‐resistant sub‐population of the HCC cell line LH86, designated LH86‐TR. Differential activation of AKT was not responsible for acquisition of TRAIL resistance.
Nianli Liu, Xiaohong Wang, Darong Yang
exaly   +3 more sources

MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation [PDF]

Cancers, 2020
The stem cell marker Musashi1 (MSI1) is highly expressed during neurogenesis and in glioblastoma (GBM). MSI1 promotes self-renewal and impairs differentiation in cancer and non-malignant progenitor cells. However, a comprehensive understanding of its role in promoting GBM-driving networks remains to be deciphered.
Jacob Haase, Markus Glass, Sebastian Simmermacher   +2 more
exaly   +4 more sources

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MSI1 and HDA6 function interdependently to control flowering time via chromatin modifications

The Plant Journal, 2021
SUMMARYMULTICOPY SUPPRESSOR OF IRA1 (MSI1) is a conserved subunit of Polycomb Repressive Complex 2 (PRC2), which mediates gene silencing by histone H3 lysine 27 trimethylation (H3K27Me3). Here, we demonstrated that MSI1 interacts with the RPD3‐like histone deacetylase HDA6 both in vitro and in vivo.
Yingchao Xu, Qing Li, Lianyu Yuan, Yisui Huang, Fu‐Yu Hung, Keqiang Wu, Songguang Yang   +6 more
openaire   +2 more sources

MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes

Trends in Cell Biology, 2005
MSI1-like WD40 repeat proteins are subunits of many protein complexes controlling chromatin dynamics. These proteins do not have any catalytic activity, but several recent studies using loss-of-function mutants established specific functions during development.
Lars Hennig, Romaric Bouveret, Wilhelm Gruissem   +2 more
exaly   +3 more sources

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease [PDF]

Cell Research, 2020
Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - including mTOR, associated with extramammary PD ...
Guang-Biao Zhou, Zhongjian Chen, Xueyun Bi   +2 more
exaly   +6 more sources

MSI1 overexpression in diffuse type of gastric cancer

Pathology - Research and Practice, 2013
Being the third most frequent cause of cancer mortality in the world, gastric cancer is the major cause of cancer-related mortality in Iran. Musashi1 recognizes a motif in the 3'UTR of target mRNAs - involved in cell cycle regulation, proliferation and apoptosis - and represses the translation of the mRNAs.
Parvaneh, Nikpour, Modjtaba, Emadi-Baygi, Faezeh, Mohhamad-Hashem, Mohamad Reza, Maracy, Shaghayegh, Haghjooy-Javanmard   +4 more
openaire   +2 more sources

Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma

Journal of Gastrointestinal Cancer, 2016
Homeobox (HOX) transcription factors are critical regulators of cell fate, stem cell functions, and gastrointestinal development. They require three-amino acid loop extension (TALE) homeodomain proteins such as Meis1 to enhance their transcriptional efficiencies.
Meysam, Moghbeli, Abolfazl, Rad, Moein, Farshchian, Negin, Taghehchian, Mehran, Gholamin, Mohammad Reza, Abbaszadegan   +5 more
openaire   +2 more sources

Msi1 promotes tumor progression by epithelial-to-mesenchymal transition in cervical cancer

Human Pathology, 2017
Musashi1 (Msi1) is an RNA-binding protein that has been reported to be a pivotal regulator in tumorigenesis and progression in several cancers. However, its function and mechanism in cervical cancer is still unknown. In this study, Msi1 expression was found elevated in cervical cancers by immunohistochemistry and correlated with poor outcomes.
Pijun, Gong, Yidong, Wang, Yane, Gao, Mei, Gao, Lixia, Liu, Ping, Qu, Xinxing, Jin, Qing, Gao   +7 more
exaly   +3 more sources

CAF-1 and MSI1-related proteins: linking nucleosome assembly with epigenetics

Trends in Plant Science, 2003
A key question in developmental biology is how epigenetic states of gene activity are maintained faithfully through successive rounds of cell division. Recent observations in Arabidopsis thaliana point to an important and conserved role for chromatin assembly factor-1 and the MSI1 class of chromatin-related proteins in perpetuating epigenetic marks on ...
openaire   +2 more sources

MSI1 associates glioblastoma radioresistance via homologous recombination repair, tumor invasion and cancer stem-like cell properties

Radiotherapy and Oncology, 2018
Glioblastoma multiforme (GBM) is the most common brain malignancy in adults, and currently available GBM treatments present several unique challenges. It is known that GBM involves cancer stem-like cells (CSCs) and tumor cells that aggressively invade normal brain tissues, and both cell types may cause resistance to radiotherapy (RT) and are thus ...
Jang-Chun Lin, Jo-Ting Tsai, Chian-Shiu Chien   +2 more
exaly   +3 more sources