Uniqueness of Sperm mtDNA as Compared to Somatic mtDNA in Ram [PDF]
International Journal of Andrology, 1980 Sperm mtDNA exhibits unique physicochemical properties compared with mtDNA from somatic tissues in the ram. The buoyant density of sperm mtDNA was 1.6983 g/cm3 while the brain, heart and liver mtDNAs was about 1.7005 g/cm3. The Tm of the liver and sperm mtDNA was 71.0°C and 69.5°C, respectively.
B, Bartoov, J, Fisher
openaire +2 more sources
Untangling Neolithic and Bronze Age mitochondrial lineages in South Asia
Annals of Human Biology, 2019 Two key moments shaped the extant South Asian gene pool within the last 10 thousand years (ka): the Neolithic period, with the advent of agriculture and the rise of the Harappan/Indus Valley Civilisation; and Late Bronze Age events that witnessed the ...
M. Silva +14 more
doaj +1 more source
Monitoring genetic population biomarkers for wastewater-based epidemiology [PDF]
, 2017 We report a rapid “sample-to-answer” platform that can be used for the quantitative monitoring of genetic biomarkers within communities through the analysis of wastewater. The assay is based on the loop-mediated isothermal amplification (LAMP) of nucleic
Cooper, Jonathan M. +4 more
core +3 more sources
Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
PLoS Genetics, 2009 Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and which are "evolutionary silent hitchhikers".
Suissa, Sarit +8 more
openaire +6 more sources
Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages
Exploration of Immunology, 2023 Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk.
Rafael Moura Maurmann +3 more
doaj +1 more source
Telomere Length as a Marker of Suicidal Risk in Schizophrenia [PDF]
Consortium Psychiatricum, 2022 BACKGROUND: Schizophrenia and suicidal behavior are associated with shortening in the length of telomeres. The aim of the study was to compare the content (pg/mcg) of telomeric repeat in DNA isolated from peripheral blood cells in three groups of ...
Natalia V. Zakharova +7 more
doaj +1 more source
Species Limits and Phylogeography of North American Cricket Frogs (Acris: Hylidae) [PDF]
, 2008 Cricket frogs are widely distributed across the eastern United States and two species, the northern cricket frog (Acris crepitans) and the southern cricket frog (A. gryllus) are currently recognized. We generated a phylogenetic hypothesis for Acris using
Berendzen, Peter B. +4 more
core +2 more sources
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +1 more source
Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy [PDF]
Stem Cell Research & Therapy, 2019 AbstractBackgroundMyopathy and exercise intolerance are prominent clinical features in carriers of a point-mutation or large-scale deletion in the mitochondrial DNA (mtDNA). In the majority of patients, the mtDNA mutation is heteroplasmic with varying mutation loads between tissues of an individual.
van Tienen, Florence +9 more
openaire +7 more sources
Mitochondrial DNA-based genetic evaluation of autochthonous cattle breeds in Croatia
Czech Journal of Animal Science, 2014 Genetic diversity and phylogenetic relationship of three Croatian autochthonous cattle breeds was analyzed using a sequence of the mtDNA D-loop region. Among Busha, Istrian, and Slavonian Syrmian Podolian cattle 146 unrelated animals were tested.
A. Ivanković +4 more
doaj +1 more source