No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]
, 2013 BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A +36 more
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Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
PLoS Genetics, 2009 Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and which are "evolutionary silent hitchhikers".
Suissa, Sarit +8 more
openaire +6 more sources
Monitoring genetic population biomarkers for wastewater-based epidemiology [PDF]
, 2017 We report a rapid “sample-to-answer” platform that can be used for the quantitative monitoring of genetic biomarkers within communities through the analysis of wastewater. The assay is based on the loop-mediated isothermal amplification (LAMP) of nucleic
Cooper, Jonathan M. +4 more
core +3 more sources
Mitochondrial DNA. Part B. Resources, 2022 The complete mitochondrial genomes were sequenced from three individuals of the endemic charr Salvelinus sp. 4 [ from Lake Nachikinskoe (Kamchatka, Russia). The complete mitochondrial genomes were 16,654 bp in size; the genome organization and GC content
Alla G. Oleinik +2 more
doaj +1 more source
Species Limits and Phylogeography of North American Cricket Frogs (Acris: Hylidae) [PDF]
, 2008 Cricket frogs are widely distributed across the eastern United States and two species, the northern cricket frog (Acris crepitans) and the southern cricket frog (A. gryllus) are currently recognized. We generated a phylogenetic hypothesis for Acris using
Berendzen, Peter B. +4 more
core +2 more sources
Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy [PDF]
Stem Cell Research & Therapy, 2019 AbstractBackgroundMyopathy and exercise intolerance are prominent clinical features in carriers of a point-mutation or large-scale deletion in the mitochondrial DNA (mtDNA). In the majority of patients, the mtDNA mutation is heteroplasmic with varying mutation loads between tissues of an individual.
van Tienen, Florence +9 more
openaire +7 more sources
Inheriting Maternal mtDNA [PDF]
Science, 2011 Sperm mitochondria are destroyed by autophagy at fertilization in C. elegans , explaining the maternal origin of mitochondria in this and perhaps other animals.
Beth Levine, Zvulun Elazar
openaire +1 more source
Phylogeography of Calomyscus elburzensis (Calomyscidae, Rodentia) around the Central Iranian Desert with Description of a New Subspecies in Center of Iranian Plateau [PDF]
Journal of Sciences, Islamic Republic of Iran, 2016 Calomyscus elburzensis Goodwin, 1938, was previously known from central and northern Iran to southern and southwestern Turkmenistan and northwestern Afghanistan.
S. Akbarirad, J. Darvish, M. Aliabadian
doaj
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. [PDF]
, 2017 Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation ...
Chwa, Marilyn +6 more
core +1 more source