Results 41 to 50 of about 156,870 (288)

Mitochondrial Dna Replacement Versus Nuclear Dna Persistence

, 2006
In this paper we consider two populations whose generations are not overlapping and whose size is large. The number of males and females in both populations is constant.
Cann R L, Kingman J F C, Maurizio Serva, Serva M, Serva M, Simon D, Thorne A G   +6 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Role of the Nrf2/ARE Pathway in the mtDNA Reparation

Frontiers in Bioscience-Landmark
Mitochondrial DNA (mtDNA) is located in the mitochondrial matrix, in close proximity to major sources of reactive oxygen species (ROS) in the cell. This makes mtDNA one of the most susceptible components to damage in the cell.
Artem P. Gureev, Ekaterina V. Chernyshova, Ekaterina P. Krutskikh, Irina S. Sadovnikova, Elena E. Tekutskaya, Anna A. Dorohova   +5 more
doaj   +1 more source

Diagnostic molecular markers and the genetic relationships among three species of the Cheilosia canicularis group (Diptera: Syrphidae)

European Journal of Entomology, 2005
To re-evaluate the taxonomic status of Cheilosia canicularis (Panzer, 1801), C. himantopus (Panzer, 1798) and C. orthotricha Vujić & Claussen, 1994, variation in the mitochondrial DNA (mtDNA) sequence of the cytochrome c oxidase subunit I (COI) gene and ...
Vesna MILANKOV, Jelena STAMENKOVIĆ, Jasmina LUDOŠKI, Gunilla STÅHLS, Ante VUJIĆ   +4 more
doaj   +1 more source

Mitochondrial DNA lineages of Italian Giara and Sarcidano horses [PDF]

, 2014
Giara and Sarcidano are 2 of the 15 extant native Italian horse breeds with limited dispersal capability that originated from a larger number of individuals. The 2 breeds live in two distinct isolated locations on the island of Sardinia. To determine the
Barbato, M., Cancedda, M., Contu, D., Francalacci, P., Morelli, L., Pala, Maria, Sanna, D., Useli, A.   +7 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The role of mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial disease

Reproduction and Fertility, 2021
There is a worldwide trend for women to have their first pregnancy later in life. However, as oocyte quality declines with maternal aging, this trend leads to an increase in subfertility.
Rachel T Cox, Joanna Poulton, Suzannah A Williams   +2 more
doaj   +1 more source

Following the rivers: historical reconstruction of California voles Microtus californicus (Rodentia: Cricetidae) in the deserts of eastern California [PDF]

, 2016
The California vole, Microtus californicus, restricted to habitat patches where water is available nearly year-round, is a remnant of the mesic history of the southern Great Basin and Mojave deserts of eastern California.
Conroy, CJ, Höhna, S, Lim, MCW, Parmenter, B, Patton, JL, Phuong, MA   +5 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evidence for a bimodal distribution of hybrid indices in a hybrid zone with high admixture [PDF]

Royal Society Open Science, 2015
The genetic structure of a hybrid zone can provide insights into the relative roles of the various factors that maintain the zone. Here, we use a multilocus approach to characterize a hybrid zone between two subspecies of killifish (Fundulus heteroclitus,
Jessica L. McKenzie, Rashpal S. Dhillon, Patricia M. Schulte   +2 more
doaj   +1 more source