β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway [PDF]
Objective(s): β-LAPachone (B-LAP) is a natural product with established anti-inflammatory properties. In this study, we investigated the protective potential of B-LAP against diabetic nephropathy in streptozotocin (STZ) induced diabetic mice.Materials ...
Davoud Sanajou+2 more
doaj +1 more source
1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics [PDF]
Objective(s): Osteosarcoma is a major solid malignant tumor of bone, possessing significant burden on healthcare due to non-availability of specific anticancer agents.
Qing Su+3 more
doaj +1 more source
The protective effect of Apelin-13 against cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway [PDF]
Objective(s): To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway.Materials and Methods: The phenylephrine-induced cardiomyocyte hypertrophy model was established in H9C2 cells in ...
Yu Peng+4 more
doaj +1 more source
Protein intake and loss of proteostasis in the eldery [PDF]
Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding ...
A. N. Kirana+2 more
doaj +1 more source
Cellular Respiration in Thymic Fragments from Mice
Background: This report aims to detail the use of the phosphorescence oxygen analyzer for in vitro investigation of thymic responses to pharmaceutical agents, in particular immunosuppressants and immunomodulators.
Mariam Alshamsi+3 more
doaj +1 more source
Tuberous Sclerosis: A Rare Cause Section of Seizure in an Older Adult [PDF]
Tuberous sclerosis is a rare autosomal dominant genetic disorder caused by mutation of TCS1 or TCS2 gene. The birth incidence is estimated to be 1 in 6000.
Shubhransu Patro+3 more
doaj +1 more source
Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia [PDF]
Background: Acute lymphoblastic leukemia (ALL) is a neoplastic disorder in which lymphoid progenitors of patients proliferate malignantly and accumulate in peripheral blood (PB), bone marrow (BM), and other sites.
Mohammad Sadeghi+6 more
doaj +1 more source
Resveratrol-induced brown fat-like phenotype in 3T3-L1 adipocytes partly via mTOR pathway
Background: Browning of white adipose tissues (WAT) is recognized as a novel way to combat obesity and its related comorbidities. Thus, a lot of dietary agents contributing to browning of WAT have been identified.
Zihui Liu+7 more
doaj +1 more source
A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1 [PDF]
Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined.
Becky Pinjou Tsai+10 more
doaj +1 more source
The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence
Aging and related diseases significantly affect the health and happiness index around the world. Cellular senescence is the basis of physiological aging and is closely related to various senile diseases.
Yukun Han+6 more
doaj +1 more source