Results 111 to 120 of about 424,341 (313)

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells [PDF]

, 2012
David K. Finlay, Ella Rosenzweig, Linda V. Sinclair, Carmen Feijoo‐Carnero, Jens Hukelmann, Julia Rolf, Andrey A. Panteleyev, Klaus Okkenhaug, Doreen A. Cantrell   +8 more
openalex   +1 more source

Correction to: Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells [PDF]

, 2020
Jiaoqin Shou, Mi Wang, Xiaolei Cheng, Xiaoyang Wang, Lifang Zhang, Yingchun Liu, Chenzhong Fei, Chunmei Wang, Feng Gu, Feiqun Xue, Juan Li, Keyu Zhang   +11 more
openalex   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Polyphenol-rich extract from Wisteria floribunda (Willd.) DC. flowers promotes osteoblast differentiation and bone formation by modulating the mTOR pathway

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the osteogenic effects of polyphenol-rich extracts from Wisteria floribunda (Willd.) DC. (W. floribunda) flowers and elucidate the underlying mechanisms. Methods: Polyphenolic compounds of W.
Jayasingha Arachchige Chathuranga Chanaka Jayasingha, Kyoung Tae Lee, Cheng-Yun Jin, Yung Hyun Choi, Chang Soo Lee, Min-Jeong Jung, Gi-Young Kim   +6 more
doaj   +1 more source

Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function [PDF]

, 2017
Eliana Ribechini, James A. Hutchinson, Sabine Hergovits, Marion Heuer, Jörg Lucas, Ulrike Schleicher, Ana-Laura Jordán Garrote, Sarah J. Potter, Paloma Riquelme, Heike Brackmann, Nora Müller, Hartmann Raifer, Ingolf Berberich, Magdalena Huber, Andreas Beilhack, Michael Lohoff, Christian Bogdan, Matthias Eyrich, Heike M. Hermanns, Edward K. Geissler, Manfred B. Lutz   +20 more
openalex   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Influence of oxidative stress on the activity of mTOR kinase in CD4+T lymphocytes in autoimmune thyroiditis

Медицинская иммунология
Currentstudies of autoimmunityprocesses areaddressing specific processes involving mitochondria, i.e., altered intracellular signaling including the generation of ROS and release of proteins from mitochondria to the cytoplasm, thus activating apoptosis ...
A. V. Burtseva, A. N. Tikhonova, Z. A. Afanasyeva, Z. I. Abramova   +3 more
doaj   +1 more source

Evaluation of mTOR-regulated mRNA translation.

, 2012
mTOR, the mammalian target of rapamycin, regulates protein synthesis (mRNA translation) by affecting the phosphorylation or activity of several translation factors. Here, we describe methods for studying the impact of mTOR signalling on protein synthesis,
A-C Gingras, AA Hayashi, BP Huang, C Mayer, CG Proud, CG Proud, D Shahbazian, J Rappsilber, J Sambrook, K Jastrzebski, L Wang, M.E. Feldman, MM Bradford, O Meyuhas, S Wullschleger, X Wang   +15 more
core   +1 more source

Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells

, 2022
Pathirennehelage Chandrasekera, Mark Perfetto, Congyu Lu, Minghui Zhuo, Harinath Bahudhanapati, Jiejing Li, Wei-Chih Chen, Pallavi Kulkarni, Laura Christian, Jun Liu, Yvette Y. Yien, Chundong Yu, Shuo Wei   +12 more
openalex   +1 more source