1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Osteosarcoma is a major solid malignant tumor of bone, possessing significant burden on healthcare due to non-availability of specific anticancer agents.
Qing Su +3 more
doaj +1 more source
Protein intake and loss of proteostasis in the eldery [PDF]
The Ukrainian Biochemical Journal, 2021 Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding ...
A. N. Kirana +2 more
doaj +1 more source
Microgravity inhibits autophagy in human capillary endothelial cells in space flight
Autophagy Reports, 2022 Microgravity and space radiation (SR) are the two environmental factors that most affect human crews in space flight (SF). The endothelium is highly sensitive to gravitational unloading and several health problems reported by astronauts derive from ...
Ivana Barravecchia, Debora Angeloni
doaj +1 more source
Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia [PDF]
ImmunoAnalysis, 2023 Background: Acute lymphoblastic leukemia (ALL) is a neoplastic disorder in which lymphoid progenitors of patients proliferate malignantly and accumulate in peripheral blood (PB), bone marrow (BM), and other sites.
Mohammad Sadeghi +6 more
doaj +1 more source
Autophagy Reports, 2022 Autophagy is a conserved intracellular degradation pathway that is essential for maintaining cellular homeostasis. Given its critical role in several disease conditions, recent studies are focussed on identifying drugs/small molecules with autophagy ...
Surendra Kumar Prajapat +4 more
doaj +1 more source
Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy [PDF]
ACS Pharmacology & Translational Science, 2022 As an important regulator of cell metabolism, proliferation, and survival, mTOR (mammalian target of rapamycin) signaling provides both a potential target for cancer treatment and a research tool for investigation of cell metabolism. One inhibitor for both mTORC1 and mTORC2 pathways, OSI-027, exhibited robust anticancer efficacy but induced side ...
Tianyi Wang +8 more
openaire +2 more sources
The protective effect of Apelin-13 against cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway.Materials and Methods: The phenylephrine-induced cardiomyocyte hypertrophy model was established in H9C2 cells in ...
Yu Peng +4 more
doaj +1 more source
β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): β-LAPachone (B-LAP) is a natural product with established anti-inflammatory properties. In this study, we investigated the protective potential of B-LAP against diabetic nephropathy in streptozotocin (STZ) induced diabetic mice.Materials ...
Davoud Sanajou +2 more
doaj +1 more source
médecine/sciences, 2013 > Les troubles cognitifs occupent une place centrale dans la schizophrenie. Parfois severes, ils apparaissent precocement au cours de l’evolution de la pathologie et ont des consequences fonctionnelles importantes, notamment sur l’integration sociale et professionnelle des patients.
Philippe Marin +2 more
openaire +1 more source
The effect of eight weeks of high-intensity interval training on p-mTOR, T-mTOR and fibrosis of cardiac tissue and insulin resistance in diabetic male Wistar rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: The mechanistic target of rapamycin (mTOR) protein complex increases in response to resistance training with a histological approach and decreases in aerobic training with a metabolic approach.
Saeed Dabagh Nikookheslat +3 more
doaj +1 more source