Results 231 to 240 of about 266,976 (313)

A cellular basis for the mammalian nocturnal-diurnal switch. [PDF]

Science
Beale AD, Christmas MJ, Rzechorzek NM, Mihut A, Zeng A, Ellis C, James NR, Smyllie NJ, Pilorz V, Richardson R, Bertelsen MF, Fazal SV, Voysey Z, Moreau K, Pelletier J, Crosby P, Peak-Chew SY, Edgar RS, Lancaster MA, Hut RA, O'Neill JS.   +20 more
europepmc   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, EarlyView.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

mTOR signalling mediates the spinal osteoblast pathotype at the curve apex in adolescent idiopathic scoliosis

Northall EH, Nicholson TA, Hazeldine J, Grover LM, McGettrick HM, Ede MN, Naylor AJ, Jones SW.   +7 more
europepmc   +1 more source

Lysolecithin Attenuates LPS-Induced Acute Liver Injury in Weaned Piglets by Inhibiting M1 Macrophage Polarization via the mTOR-Glycolysis Pathway. [PDF]

Biology (Basel)
Shu K, Xiong J, Xu X, Deng Y, Xiao K, Yang H, Liu Y, Chen S.   +7 more
europepmc   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Quercetin regulates autophagy and attenuates airway inflammation in a murine model of asthma: association with PI3K/Akt/mTOR signaling pathway modulation. [PDF]

Front Pharmacol
Lang L, Liu S, Zhang W, Zhang J, Liu H.
europepmc   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Exosomal miR-199a-3p derived from follicular fluid modulates the immune microenvironment in polycystic ovary syndrome by regulating macrophage polarization. [PDF]

J Ovarian Res
Zhen X, Zhu L, Guan L, Wei C, Li D, Li Y, Xiang S, Lian F.   +7 more
europepmc   +1 more source

Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling

Yueqin Bai, Yabin Gong, Ruifang Cui, Qingpeng Deng, Xiaozhen ZHAO, Chang Liu, Longke Dong   +6 more
openalex   +1 more source

SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

Advanced Science, EarlyView.
This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen, Lihua Yang, Shuang Cai, Yunxia Liu, Jianan Fan, Peng Wu, Beibei Gao, Xiaoge Xie, Hong Sun, Sida Qin, Qiao Yi Chen   +10 more
wiley   +1 more source