Results 31 to 40 of about 266,976 (313)

The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence

Frontiers in Bioscience-Landmark, 2023
Aging and related diseases significantly affect the health and happiness index around the world. Cellular senescence is the basis of physiological aging and is closely related to various senile diseases.
Yukun Han, Yifan Liu, Yanhua Zhang, Wei Wang, Tongtong Lv, Jinbai Huang, Xiaochun Peng   +6 more
doaj   +1 more source

Tuberous Sclerosis: A Rare Cause Section of Seizure in an Older Adult [PDF]

Journal of Clinical and Diagnostic Research, 2020
Tuberous sclerosis is a rare autosomal dominant genetic disorder caused by mutation of TCS1 or TCS2 gene. The birth incidence is estimated to be 1 in 6000.
Shubhransu Patro, Pankaj Kumar Khora, Bijay Kumar Sahoo, Debasis Pathi   +3 more
doaj   +1 more source

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1 [PDF]

Open Biology, 2014
Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined.
Becky Pinjou Tsai, Judith Jimenez, Sharon Lim, Kerry D. Fitzgerald, Min Zhang, Charles T. H. Chuah, Haley Axelrod, Luke Nelson, S. Tiong Ong, Bert L. Semler, Marian L. Waterman   +10 more
doaj   +1 more source

Metabolic reprogramming of Salmonella infected macrophages and its modulation by iron availability and the mTOR pathway

Microbial Cell, 2019
Iron is an essential nutrient for immune cells and microbes, therefore the control of its homeostasis plays a decisive role for infections. Moreover, iron affects metabolic pathways by modulating the translational expression of the key tricarboxylic acid
Julia Telser, Chiara Volani, Richard Hilbe, Markus Seifert, Natascha Brigo, Giuseppe Paglia, Günter Weiss   +6 more
doaj   +1 more source

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Molecular & Cellular Oncology, 2019
Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle ...
Luca Drusian, Alessandra Boletta
doaj   +1 more source

Molecular mechanisms of pain regulation in patients with osteoarthritis

Научно-практическая ревматология, 2016
Objective: to study the mechanisms determining the level of pain on the basis of an analysis of the expression profiles of the genes involved in joint destruction, inflammation, and metabolic regulation in the blood of patients with osteoarthritis (OA ...
E. V. Chetina, G. A. Markova, E. A. Taskina, E. P. Sharapova, N. G. Kashevarova, L. I. Alekseeva, V. V. Kolomatsky, M. A. Makarov, A. L. Logunov, S. A. Makarov, A. N. Kuzin   +10 more
doaj   +1 more source

Phosphatidic acid: a lipid regulator of the Hippo pathway

Molecular & Cellular Oncology, 2019
The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein ...
Han Han, Rebecca Vargas, Gayoung Seo, Wenqi Wang   +3 more
doaj   +1 more source

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor [PDF]

Nature, 2016
Precision medicines exert selective pressure on tumour cells that leads to the preferential growth of resistant subpopulations, necessitating the development of next-generation therapies to treat the evolving cancer. The PIK3CA-AKT-mTOR pathway is one of the most commonly activated pathways in human cancers, which has led to the development of small ...
Rodrik-Outmezguine, Vanessa S., Okaniwa, Masanori, Yao, Zhan, Novotny, Chris J., McWhirter, Claire, Banaji, Arpitha, Won, Helen, Wong, Wai, Berger, Mike, de Stanchina, Elisa, Barratt, Derek G., Cosulich, Sabina, Klinowska, Teresa, Rosen, Neal, Shokat, Kevan M.   +14 more
openaire   +2 more sources

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

The Activation of PI3K/AKT/mTOR Signaling Pathway in Response to Cabazitaxel Treatment in Metastatic Castration-Resistant Prostate Cancer Cells

European Journal of Biology, 2021
Objective: Despite advances in treatment approaches, metastatic castration-resistant prostate cancer (mCRPC) remains a clinical challenge to treat. Cabazitaxel (Cab), a third-line chemotherapy option for mCRPC, exhibits limited efficiency due to the ...
Işıl Ezgi Eryılmaz, Gamze Güney Eskiler, Ceyda Çolakoğlu, Ünal Egeli, Gülşah Çeçener   +4 more
doaj   +1 more source