Results 41 to 50 of about 427,120 (360)
GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]
, 2015 The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott +60 more
core +3 more sources
Molecular & Cellular Oncology, 2019 Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle ...
Luca Drusian, Alessandra Boletta
doaj +1 more source
Molecular mechanisms of pain regulation in patients with osteoarthritis
Научно-практическая ревматология, 2016 Objective: to study the mechanisms determining the level of pain on the basis of an analysis of the expression profiles of the genes involved in joint destruction, inflammation, and metabolic regulation in the blood of patients with osteoarthritis (OA ...
E. V. Chetina +10 more
doaj +1 more source
Placental DEPTOR as a stress sensor during pregnancy [PDF]
, 2011 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y +4 more
core +2 more sources
Phosphatidic acid: a lipid regulator of the Hippo pathway
Molecular & Cellular Oncology, 2019 The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein ...
Han Han +3 more
doaj +1 more source
Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D +4 more
core +2 more sources
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor [PDF]
Nature, 2016 Precision medicines exert selective pressure on tumour cells that leads to the preferential growth of resistant subpopulations, necessitating the development of next-generation therapies to treat the evolving cancer. The PIK3CA-AKT-mTOR pathway is one of the most commonly activated pathways in human cancers, which has led to the development of small ...
Rodrik-Outmezguine, Vanessa S. +14 more
openaire +2 more sources
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]
, 2018 Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea +9 more
core +3 more sources
Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]
, 2018 Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin +9 more
core +2 more sources
4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source