Results 41 to 50 of about 400,251 (340)
Platelets, 2020 Phosphatidylinositol 3 kinase (PI3K) is a major player in platelet activation and regulates thrombus formation and stabilization. The β isoform of PI3K is implicated in integrin αIIbβ3 outside-in signaling, is required for the phosphorylation of Akt, and
Mauro Torti +7 more
doaj +1 more source
Modified Poisson compositing technique on skewed grid
AIMS Mathematics, 2022 Image compositing is the process of seamlessly inserting a portion of a source image into a target image to create a new desirable image. This work describes an image composition approach based on numerical differentiation utilizing the Laplacian ...
Nordin Saad +2 more
doaj +1 more source
Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies. [PDF]
, 2018 The present study was designed to examine the potential cellular antiseizure mechanisms of everolimus, a mechanistic target of rapamycin (mTOR) pathway blocker, in pediatric epilepsy cases. Cortical tissue samples obtained from pediatric patients (n
Barry, Joshua +8 more
core +2 more sources
Elucidating the role of Lkb1 and mTOR in adipose tissue
Adipocyte, 2019 Adipose tissues, function as energy metabolism and endocrine organ, are closely associated with metabolic diseases such as obesity, insulin resistance and diabetes.
Ziye Xu +4 more
doaj +1 more source
GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]
, 2015 The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott +60 more
core +2 more sources
mTOR Pathway and mTOR Inhibitors in Cancer Therapy [PDF]
British Journal of Clinical Pharmacology, 2011 The latest in the series of monographs Cancer Drug Discovery and Development is mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Rapamycin was first employed as an antifungal agent in humans and named for the Polynesians (Papa Nui) who inhabited Easter Island, where it was isolated from the bacteria Streptomyces hygroscopidcus.
openaire +2 more sources
mTOR inhibitors response and mTOR pathway in pancreatic neuroendocrine tumors [PDF]
Endocrine-Related Cancer, 2016 Medical therapy of pancreatic neuroendocrine tumors (P-NET) may take advantage of Everolimus treatment. However, the extent of therapeutic response cannot be predicted. This study was aimed to identify the possible predictive markers of response to Everolimus in P-NET. We found that Everolimus reduced the cell viability and induced apoptosis in primary
FALLETTA, Simona +11 more
openaire +4 more sources
Placental DEPTOR as a stress sensor during pregnancy [PDF]
, 2011 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y +4 more
core +2 more sources
4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
mTOR, Cancer and Transplantation [PDF]
American Journal of Transplantation, 2008 One of the most clinically important molecular signalling networks to emerge over the past decade is the mammalian target of rapamycin (mTOR) pathway. mTOR, the protein kinase at the core of this intricate and continually evolving pathway, controls cellular growth and behavior, impacting vital processes from immune reactivity to cancer progression.
Edward K Geissler +2 more
openaire +3 more sources