Results 51 to 60 of about 427,120 (360)

Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund.Emerging data suggest that nutritional status and body weight are related to reproductive function, and nutrient imbalances during pregnancy lead to changes in the ...
Foster, H, Goumenou, A, Harvey, AJ, Kara, A, Karteris, E, Mparmpakas, D, Zachariades, E   +6 more
core   +2 more sources

The Regulatory Role of MeAIB in Protein Metabolism and the mTOR Signaling Pathway in Porcine Enterocytes. [PDF]

, 2018
Amino acid transporters play an important role in cell growth and metabolism. MeAIB, a transporter-selective substrate, often represses the adaptive regulation of sodium-coupled neutral amino acid transporter 2 (SNAT2), which may act as a receptor and ...
Ji, Peng, Li, Guangran, Li, Jianjun, Tan, Bie, Tang, Yulong, Yin, Yulong   +5 more
core   +2 more sources

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves, Barbi, Battaglia, Bental, Borsellino, Carr, Cipolletta, Cobbold, Coloff, Cunningham, Curti, Cybulski, Dang, Deiuliis, Delgoffe, Delgoffe, Feuerer, Fisson, Fox, Frauwirth, GabryÅ¡ová, Greiner, Guertin, Guertin, Gulen, Hardie, Hardie, Howie, Hörig, Jacobs, Jones, Jordan, Kane, Lee, Lord, Makki, Matarese, Matteoli, Mellor, Metz, Michalek, Munder, Munder, Oh, Olefsky, Ouchi, Peter, Powell, Powell, Powell, Powell, Procaccini, Procaccini, Sakaguchi, Sarbassov, Shevach, Shi, Sitkovsky, Smith, Thornton, Vanasek, Vander Heiden, Vukmanovic-Stejic, Waickman, Wieman, Winer, Yang, Zeng, Zheng   +68 more
core   +2 more sources

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Cells, 2019
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng   +4 more
doaj   +1 more source

Sirolimus Therapy and Follow-up in a Patient with Severe Congenital Hyperinsulinism Following Subtotal Pancreatectomy

JCRPE, 2021
Congenital hyperinsulinism (CHI) is the most common cause of severe, persistent hypoglycemia in neonates and infants. If the patient does not respond to medical treatment the currently available treatment is subtotal pancreatectomy, but some patients ...
Qiong Chen, Yongxing Chen, Xiaohong Wang, Haihua Yang, Yingxian Zhang, Xiaojing Liu, Yun Yan, Haiyan Wei   +7 more
doaj   +1 more source

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]

, 2019
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F, Che, Li, Chen, Xin, Evert, Matthias, Hu, Junjie, Liu, Xianqiong, Lu, Xinjun, Song, Xinhua, Su, Tao, Utpatel, Kirsten, Wang, Jingxiao, Wang, Pan, Xu, Meng, Zhang, Jie, Zhang, Yi   +14 more
core   +1 more source

Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

Pharmaceutical Biology, 2019
Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro.
Keun-Hyeun Lee, Dabin Choi, Seung-Il Jeong, Sang-Jun Kim, Chang Hyun Lee, Hyung-Sik Seo, Han-Sol Jeong   +6 more
doaj   +1 more source

Control of muscle protein synthesis in response to exercise and amino acids

Journal of Physical Fitness and Sports Medicine, 2012
There is a general consensus that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. The intracellular signaling pathways through the mammalian target of rapamycin (mTOR),
Naoya Nakai, Fuminori Kawano, Yoshinobu Ohira   +2 more
doaj   +1 more source

Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen

Platelets, 2020
Phosphatidylinositol 3 kinase (PI3K) is a major player in platelet activation and regulates thrombus formation and stabilization. The β isoform of PI3K is implicated in integrin αIIbβ3 outside-in signaling, is required for the phosphorylation of Akt, and
Mauro Torti, Daria Manganaro, Caterina Visconte, Marta Zarà, Jessica Canino, Mauro Vismara, Ilaria Canobbio, Gianni Francesco Guidetti   +7 more
doaj   +1 more source

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

Molecules, 2020
Alzheimer’s disease (AD) is one of the utmost chronic neurodegenerative disorders, which is characterized from a neuropathological point of view by the aggregates of amyloid beta (Aβ) peptides that are deposited as senile plaques and tau ...
Md. Sahab Uddin, Md. Tanvir Kabir, Kamal Niaz, Philippe Jeandet, Christophe Clément, Bijo Mathew, Abdur Rauf, Kannan R.R. Rengasamy, Eduardo Sobarzo-Sánchez, Ghulam Md Ashraf, Lotfi Aleya   +10 more
doaj   +1 more source