Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]
, 2016 Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M. +5 more
core +2 more sources
OncoImmunology, 2018 mTOR inhibition can promote or inhibit immune responses in a context dependent manner, but whether this will represent a net benefit or be contraindicated in the context of immunooncology therapies is less understood.
Sophie Langdon +10 more
doaj +1 more source
Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression, as a novel component, in a rat model of PCOS [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Zinc is an effective factor in the reproductive system. Insulin resistance (IR) is known as an important disorder in patients with polycystic ovary syndrome (PCOS).
Faeze Fazel Torshizi +5 more
doaj +1 more source
mTOR and lymphocyte metabolism [PDF]
Current Opinion in Immunology, 2013 Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures.
Hongbo Chi, Hu Zeng
openaire +3 more sources
Anti-aging Effect of Ginseng Extract and Its Mechanism on Drosophila melanogaster
Shipin gongye ke-ji, 2023 Objective: Based on the model organism of Drosophila melanogaster, the anti-aging effect of ginseng extract and its mechanism on Drosophila melanogaster were investigated. Methods: The composition of ginsenosides in ginseng extract were analyzed by HPLC.
Jilan WANG +6 more
doaj +1 more source
Deconvoluting mTOR biology [PDF]
Cell Cycle, 2012 In metazoans, TOR is an essential protein that functions as a master regulator of cellular growth and proliferation. Over the past decade, there has been an explosion of information about this critical master kinase, ranging from the composition of the TOR protein complex to its ability to act as an integrator of numerous extracellular signals ...
Weber, Jason D, Gutmann, David H
openaire +4 more sources
Metastatic Group 3 Medulloblastoma in a Patient With Tuberous Sclerosis Complex: Case Description and Molecular Characterization of the Tumor [PDF]
, 2015 Medulloblastoma is the most common pediatric brain tumor. We describe a child with tuberous sclerosis complex that developed a Group 3, myc overexpressed, metastatic medulloblastoma (MB).
Carai, Andrea +14 more
core +1 more source
Unbiased translation proteomics upon cell stress
Molecular & Cellular Oncology, 2020 The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently
Kevin Klann, Christian Münch
doaj +1 more source
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]
, 2018 Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea +9 more
core +3 more sources
Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
Molecular & Cellular Oncology, 2020 We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET.
Alexia Hervieu, Stéphanie Kermorgant
doaj +1 more source