Results 1 to 10 of about 74,969 (245)
Glutaminolysis feeds mTORC1 [PDF]
Cell Cycle, 2012 Glutamine is an important amino acid from a metabolic point of view. As an amino acid and a precursor for other amino acids, it sustains protein synthesis. It is also required for production of nucleotides (pyrimidines) and α-ketoglutarate (αKG). αKG is produced via double deamination of glutamine, a process termed glutaminolysis. Glutamine is first de-
Raúl V. Durán, Michael N. Hall
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A lipid off-switch for mTORC1 [PDF]
Molecular & Cellular Oncology, 2017 Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β ...
Alexander Wallroth, Volker Haucke
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Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
PLoS Biology, 2022 Mechanistic target of rapamycin complex I (mTORC1) is central to cellular metabolic regulation. mTORC1 phosphorylates a myriad of substrates, but how different substrate specificity is conferred on mTORC1 by different conditions remains poorly defined ...
Kristina Li +5 more
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Nutrient regulation of mTORC1 at a glance [PDF]
Journal of Cell Science, 2019 The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic and catabolic processes, mTOR complex 1 (mTORC1) signaling has established ...
K. J. Condon, D. Sabatini
semanticscholar +4 more sources
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1 [PDF]
Cell Reports, 2017 The mechanistic target of rapamycin (mTOR) integrates numerous stimuli and coordinates the adaptive response of many cellular processes. To accomplish this, mTOR associates with distinct co-factors that determine its signaling output. While many of these
Michael C. Brown, Matthias Gromeier
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Regulation of nuclear mTORC1 [PDF]
Molecular & Cellular Oncology, 2021 mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear ...
Xin Zhou, Yanghao Zhong, Jin Zhang
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MTORC1 and the Rebirth of Stemness [PDF]
Developmental Cell, 2020 MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.
Christopher J. Lengner +1 more
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Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
Nature, 2023 The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy^ 1 . The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1)^ 2 – 5 is unique in its mTORC1 substrate recruitment mechanism, which is ...
Zhicheng Cui +7 more
semanticscholar +1 more source
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
Nature Communications, 2023 Identifying the mechanisms underlying the regulation of immune checkpoint molecules and the therapeutic impact of targeting them in cancer is critical.
Heng-Jia Liu +7 more
semanticscholar +1 more source
Regulation and metabolic functions of mTORC1 and mTORC2.
Physiological Reviews, 2021 Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves crosstalk between growth ...
A. Szwed, Eugene Kim, E. Jacinto
semanticscholar +1 more source