Results 1 to 10 of about 60,518 (148)
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1 [PDF]
Cell Reports, 2017 The mechanistic target of rapamycin (mTOR) integrates numerous stimuli and coordinates the adaptive response of many cellular processes. To accomplish this, mTOR associates with distinct co-factors that determine its signaling output. While many of these co-factors are known, in many cases their function and regulation remain opaque.
Michael C. Brown, Matthias Gromeier
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Regulation of nuclear mTORC1 [PDF]
Molecular & Cellular Oncology, 2021 mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear ...
Xin Zhou, Yanghao Zhong, Jin Zhang
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Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy
Autophagy Reports, 2023 Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response.
Mariana I. Capurro +3 more
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Glutaminolysis feeds mTORC1 [PDF]
Cell Cycle, 2012 Glutamine is an important amino acid from a metabolic point of view. As an amino acid and a precursor for other amino acids, it sustains protein synthesis. It is also required for production of nucleotides (pyrimidines) and α-ketoglutarate (αKG). αKG is produced via double deamination of glutamine, a process termed glutaminolysis. Glutamine is first de-
Durán, Raúl V., Hall, Michael N.
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COVID 19 in a family with rare genetic disease of the nervous system
Неврология, нейропсихиатрия, психосоматика, 2022 We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and ...
M. Yu. Martynov +2 more
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A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
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Cellular Uptake, Metabolism and Sensing of Long-Chain Fatty Acids
Frontiers in Bioscience-Landmark, 2023 Fatty acids (FAs) are critical nutrients that regulate an organism’s health and development in mammal. Long-chain fatty acids (LCFAs) can be divided into saturated and unsaturated fatty acids, depending on whether the carbon chain contains at least 1 ...
Qiburi He +4 more
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Spatiotemporal feedforward between PKM2 tetramers and mTORC1 prompts mTORC1 activation
Physical Biology, 2022 Abstract Most mammalian cells couple glucose availability to anabolic processes via the mTORC1 pathway. However, the mechanism by which fluctuations in glucose availability are rapidly translated into mTORC1 signals remains elusive. Here, we show that cells rapidly respond to changes in glucose availability through the spatial coupling ...
Yu Xia +3 more
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Cancer Cell, 2014 A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.
Sanchez-Gurmaches, Joan +1 more
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Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
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